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View Structure Prediction Details

Protein: ASH2L
Organism: Homo sapiens
Length: 628 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ASH2L.

Description E-value Query
Range
Subject
Range
gi|3046997, gi|4... - gi|4757790|ref|NP_004665.1| ash2-like [Homo sapiens], gi|3046997|gb|AAC13564.1| ash2l1 [Homo sapiens...
0.0 [1..628] [1..628]
gi|114619679 - gi|114619679|ref|XP_001170172.1| PREDICTED: ash2 (absent, small, or homeotic)-like isoform 4 [Pan tr...
0.0 [1..628] [1..628]
gi|73979195 - gi|73979195|ref|XP_848878.1| PREDICTED: similar to Set1/Ash2 histone methyltransferase complex subun...
0.0 [1..628] [1..628]
ASH2L_MOUSE - Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Mus musculus GN=Ash2l PE=1 SV=1
0.0 [13..628] [13..623]
gi|76655880, gi|... - gi|76655880|ref|XP_870662.1| PREDICTED: similar to Set1/Ash2 histone methyltransferase complex subun...
0.0 [1..628] [1..629]
gi|109503505 - gi|109503505|ref|XP_214369.4| PREDICTED: similar to Set1/Ash2 histone methyltransferase complex subu...
0.0 [25..628] [25..629]

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Predicted Domain #1
Region A:
Residues: [1-97]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAGAGPGQ EAGAGPGPGA VANATGAEEG EMKPVAAGAA APPGEGISAA PTVEPSSGEA  60
   61 EGGEANLVDV SGGLETESSN GKDTLEGAGD TSEVMDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [98-269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAGSVDEENG RQLGEVELQC GICTKWFTAD TFGIDTSSCL PFMTNYSFHC NVCHHSGNTY  60
   61 FLRKQANLKE MCLSALANLT WQSRTQDEHP KTMFSKDKDI IPFIDKYWEC MTTRQRPGKM 120
  121 TWPNNIVKTM SKERDVFLVK EHPDPGSKDP EEDYPKFGLL DQDLSNIGPA YD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.522879
Match: 2f6jA
Description: No description for 2f6jA was found.

Predicted Domain #3
Region A:
Residues: [270-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQKQSSAVST SGNLNGGIAA GSSGKGRGAK RKQQDGGTTG TTKKARSDPL FSAQRLPPHG  60
   61 YPLEHPFNKD GYRYILAEPD PH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [352-628]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APDPEKLELD CWAGKPIPGD LYRACLYERV LLALHDRAPQ LKISDDRLTV VGEKGYSMVR  60
   61 ASHGVRKGAW YFEITVDEMP PDTAARLGWS QPLGNLQAPL GYDKFSYSWR SKKGTKFHQS 120
  121 IGKHYSSGYG QGDVLGFYIN LPEDTETAKS LPDTYKDKAL IKFKSYLYFE EKDFVDKAEK 180
  181 SLKQTPHSEI IFYKNGVNQG VAYKDIFEGV YFPAISLYKS CTVSINFGPC FKYPPKDLTY 240
  241 RPMSDMGWGA VVEHTLADVL YHVETEVDGR RSPPWEP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.0
Match: 2fnjA
Description: No description for 2fnjA was found.

Predicted functions:

Term Confidence Notes
binding 2.40096962515027 bayes_pls_golite062009
transcription regulator activity 2.15398264148864 bayes_pls_golite062009
nucleic acid binding 1.95513305822187 bayes_pls_golite062009
protein binding 1.80794638640093 bayes_pls_golite062009
DNA binding 1.80079581406991 bayes_pls_golite062009
transcription activator activity 1.26528137349343 bayes_pls_golite062009
transcription factor activity 1.15427978494805 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle