YRC Public Data Repository - Protein Structure Prediction

Protein:	PARD6B
Organism:	Homo sapiens
Length:	372 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PARD6B.

Description	E-value	Query Range	Subject Range
gi\|157820359, gi... - ref\|XP_342590.1\| similar to PAR6B [Rattus norvegicus], gi\|157820359\|ref\|NP_001102079.1\| par-6 (parti...	1.0E-65	[1..372]	[1..372]
PAR6B_MOUSE, PA6... - Partitioning defective 6 homolog beta OS=Mus musculus GN=Pard6b PE=1 SV=1, (Q9JK83) Partitioning def...	4.0E-65	[1..372]	[1..371]
gi\|7532797, gi\|1... - gi\|7532797\|gb\|AAF63238.1\|AF152346_1 PAR-6 [Xenopus laevis], gi\|147904716\|ref\|NP_001081992.1\| Par-6 p...	2.0E-63	[1..372]	[1..377]
gi\|73992585 - gi\|73992585\|ref\|XP_543050.2\| PREDICTED: similar to Partitioning defective-6 homolog beta (PAR-6 beta...	9.0E-62	[1..372]	[195..564]
gi\|89269556 - gi\|89269556\|emb\|CAJ82343.1\| par-6 partitioning defective 6 homolog beta (C. elegans) [Xenopus tropic...	1.0E-60	[1..355]	[1..360]
gi\|113206068, gi... - gi\|113206068\|ref\|NP_001038106.1\| par-6 partitioning defective 6 homolog beta [Gallus gallus], gi\|110...	2.0E-59	[1..372]	[1..370]
gi\|76633889 - gi\|76633889\|ref\|XP_588744.2\| PREDICTED: similar to Partitioning defective-6 homolog beta (PAR-6 beta...	2.0E-56	[11..372]	[2..364]
gi\|109091851 - gi\|109091851\|ref\|XP_001100889.1\| PREDICTED: PAR-6 beta [Macaca mulatta]	9.0E-55	[1..372]	[1..380]

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Predicted Domain #1

Region A:
Residues: [1-95]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRSHRHGAG SGCLGTMEVK SKFGAEFRRF SLERSKPGKF EEFYGLLQHV HKIPNVDVLV  60
   61 GYADIHGDLL PINNDDNYHK AVSTANPLLR IFIQK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.522879
Match:	1wmhB
Description:	Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.24212855645397	bayes_pls_golite062009
phospholipase binding	1.34684798434912	bayes_pls_golite062009
protein binding	1.04550817342273	bayes_pls_golite062009
signal transducer activity	0.397569963508051	bayes_pls_golite062009
molecular transducer activity	0.397569963508051	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [96-258]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEEADYSAFG TDTLIKKKNV LTNVLRPDNH RKKPHIVISM PQDFRPVSSI IDVDILPETH  60
   61 RRVRLYKYGT EKPLGFYIRD GSSVRVTPHG LEKVPGIFIS RLVPGGLAQS TGLLAVNDEV 120
  121 LEVNGIEVSG KSLDQVTDMM IANSRNLIIT VRPANQRNNV VRN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	22.30103
Match:	1nf3C
Description:	GTPase-binding domain of the cell polarity protein par6 (Par-6B)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	3.2595117613307	bayes_pls_golite062009
cytoskeletal protein binding	2.48224018205024	bayes_pls_golite062009
protein binding	2.35875654816667	bayes_pls_golite062009
PDZ domain binding	1.4161955255054	bayes_pls_golite062009
actin binding	1.28302718651984	bayes_pls_golite062009
transporter activity	0.782216866213126	bayes_pls_golite062009
transmembrane transporter activity	0.699604120098573	bayes_pls_golite062009
substrate-specific transporter activity	0.434921764966531	bayes_pls_golite062009
transcription regulator activity	0.387065538161985	bayes_pls_golite062009
protein domain specific binding	0.30840185305841	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.250590541549843	bayes_pls_golite062009
signal transducer activity	0.211809989510755	bayes_pls_golite062009
molecular transducer activity	0.211809989510755	bayes_pls_golite062009
receptor binding	0.00333430733556384	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [259-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRTSGSSGQS TDNSLLGYPQ QIEPSFEPED EDSEEDDIII EDNGVPQQIP KAVPNTESLE  60
   61 SLTQIELSFE SGQNGFIPSN EVSLAAIASS SNTEFETHAP DQKLLEEDGT IITL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.238	d.14.1	Ribosomal protein S5 domain 2-like
View	Download	0.312	a.7.1	Spectrin repeat

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: