YRC Public Data Repository - Protein Structure Prediction

Protein:	AKAP8
Organism:	Homo sapiens
Length:	692 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AKAP8.

Description	E-value	Query Range	Subject Range
gi\|22713396 - gi\|22713396\|gb\|AAH37270.1\| AKAP8 protein [Homo sapiens]	0.0	[1..692]	[1..692]
gi\|539937 - gi\|539937\|pir\|\|A53414 A-kinase anchor protein 95, AKAP95 - rat	0.0	[1..692]	[75..761]
AKAP8_MOUSE - A-kinase anchor protein 8 OS=Mus musculus GN=Akap8 PE=1 SV=1	0.0	[1..692]	[1..687]
gi\|76621250 - gi\|76621250\|ref\|XP_601194.2\| PREDICTED: similar to protein kinase A-anchoring protein 95 isoform 5 [...	0.0	[1..692]	[1..683]
gi\|109123773 - gi\|109123773\|ref\|XP_001112993.1\| PREDICTED: similar to A-kinase anchor protein 8 [Macaca mulatta]	0.0	[39..692]	[5..655]
AKAP8_CANLF - A-kinase anchor protein 8 OS=Canis lupus familiaris GN=AKAP8 PE=1 SV=1 gi\|55742860 - ref\|NP_001007124.1\| A kinase (PRKA) anchor protein 8 [Canis familiaris]	0.0	[1..692]	[1..698]

Back

Predicted Domain #1

Region A:
Residues: [1-112]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQGYGGYGA WSAGPANTQG AYGTGVASWQ GYENYNYYGA QNTSVTTGAT YSYGPASWEA  60
   61 AKANDGGLAA GAPAMHMASY GPEPCTDNSD SLIAKINQRL DMMSKEGGRG GS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [113-310]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGGGEGIQDR ESSFRFQPFE SYDSRPCLPE HNPYRPSYSY DYEFDLGSDR NGSFGGQYSE  60
   61 CRDPARERGS LDGFMRGRGQ GRFQDRSNPG TFMRSDPFVP PAASSEPLST PWNELNYVGG 120
  121 RGLGGPSPSR PPPSLFSQSM APDYGVMGMQ GAGGYDSTMP YGCGRSQPRM RDRDRPKRRG 180
  181 FDRFGPDGTG RKRKQFQL

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	9.39794
Match:	PF04988.3
Description:	No description for PF04988.3 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [311-692]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YEEPDTKLAR VDSEGDFSEN DDAAGDFRSG DEEFKGEDEL CDSGRQRGEK EDEDEDVKKR  60
   61 REKQRRRDRT RDRAADRIQF ACSVCKFRSF DDEEIQKHLQ SKFHKETLRF ISTKLPDKTV 120
  121 EFLQEYIVNR NKKIEKRRQE LMEKETAKPK PDPFKGIGQE HFFKKIEAAH CLACDMLIPA 180
  181 QPQLLQRHLH SVDHNHNRRL AAEQFKKTSL HVAKSVLNNR HIVKMLEKYL KGEDPFTSET 240
  241 VDPEMEGDDN LGGEDKKETP EEVAADVLAE VITAAVRAVD GEGAPAPESS GEPAEDEGPT 300
  301 DTAEAGSDPQ AEQLLEEQVP CGTAHEKGVP KARSEAAEAG NGAETMAAEA ESAQTRVAPA 360
  361 PAAADAEVEQ TDAESKDAVP TE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	8.0
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits