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View Structure Prediction Details

Protein: HNRNPF
Organism: Homo sapiens
Length: 415 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPF.

Description E-value Query
Range
Subject
Range
gi|76633747 - gi|76633747|ref|XP_881817.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
2.0E-55 [1..414] [1..420]
gi|73976793 - gi|73976793|ref|XP_857617.1| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 1 ...
1.0E-54 [1..409] [1..425]
gi|55959639, gi|... - gi|66267552|gb|AAH94755.1| PABPC4 protein [Homo sapiens], gi|55962217|emb|CAI12298.1| poly(A) bindin...
gi|114555673 - gi|114555673|ref|XP_001170937.1| PREDICTED: poly A binding protein, cytoplasmic 4 isoform 1 [Pan tro...
2.0E-54 [1..414] [1..422]

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Predicted Domain #1
Region A:
Residues: [1-110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLGPEGGEG FVVKLRGLPW SCSVEDVQNF LSDCTIHDGA AGVHFIYTRE GRQSGEAFVE  60
   61 LGSEDDVKMA LKKDRESMGH RYIEVFKSHR TEMDWVLKHS GPNSADSAND 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 2db1A
Description: No description for 2db1A was found.

Predicted Domain #2
Region A:
Residues: [111-202]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFVRLRGLPF GCTKEEIVQF FSGLEIVPNG ITLPVDPEGK ITGEAFVQFA SQELAEKALG  60
   61 KHKERIGHRY IEVFKSSQEE VRSYSDPPLK FM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.39794
Match: 1wg5A
Description: Solution structure of the first RRM domain in heterogeneous nuclear ribonucleoprotein H
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.92126426323641 bayes_pls_golite062009
4.67888641618755 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 1.92450390013691 bayes_pls_golite062009
DNA binding 1.8021593476478 bayes_pls_golite062009
snRNA binding 1.76821382294389 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
transcription factor activity 1.15127506309683 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
U1 snRNA binding 0.612226940931031 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
sequence-specific DNA binding 0.383589644462932 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [203-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVQRPGPYDR PGTARRYIGI VKQAGLERMR PGAYSTGYGG YEEYSGLSDG YGFTTDLFGR  60
   61 DLSYCLSGMY DHRYGDSEFT VQSTTG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.15
Match: 1jchA
Description: Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [289-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HCVHMRGLPY KATENDIYNF FSPLNPVRVH IEIGPDGRVT GEADVEFATH EEAVAAMSKD  60
   61 RANMQHRYIE LFLNSTTGAS NGAYSSQVMQ GMGVSAAQAT YSGLESQSVS GCYGAGYSGQ 120
  121 NSMGGYD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.30103
Match: 2hgnA
Description: No description for 2hgnA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle