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View Structure Prediction Details

Protein: LGALS3BP
Organism: Homo sapiens
Length: 585 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LGALS3BP.

Description E-value Query
Range
Subject
Range
gi|55726991 - gi|55726991|emb|CAH90253.1| hypothetical protein [Pongo abelii]
LG3BP_PONAB - Galectin-3-binding protein OS=Pongo abelii GN=LGALS3BP PE=1 SV=1
0.0 [1..585] [1..584]
gi|114670739, gi... - gi|55646067|ref|XP_511716.1| PREDICTED: galectin 3 binding protein isoform 6 [Pan troglodytes], gi|1...
0.0 [1..585] [1..585]
LG3BP_MOUSE - Galectin-3-binding protein OS=Mus musculus GN=Lgals3bp PE=1 SV=1
0.0 [13..584] [13..576]
gi|109118737 - gi|109118737|ref|XP_001109047.1| PREDICTED: galectin 3 binding protein [Macaca mulatta]
0.0 [1..585] [3..586]
LG3BP_RAT - Galectin-3-binding protein OS=Rattus norvegicus GN=Lgals3bp PE=1 SV=2
0.0 [13..585] [13..574]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD NLWDLTDASV  60
   61 VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL ADCKSLGWLK SNCRHERDAG 120
  121 VVCT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.154902
Match: 1by2A
Description: STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.46938749190409 bayes_pls_golite062009
protein binding 1.28706760832588 bayes_pls_golite062009
transmembrane receptor activity 1.08279686816382 bayes_pls_golite062009
receptor activity 0.985580503809665 bayes_pls_golite062009
scavenger receptor activity 0.538000563261165 bayes_pls_golite062009
signal transducer activity 0.493153860184561 bayes_pls_golite062009
molecular transducer activity 0.493153860184561 bayes_pls_golite062009
lipoprotein binding 0.30519891363142 bayes_pls_golite062009
low-density lipoprotein binding 0.12762152483878 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [125-236]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NETRSTHTLD LSRELSEALG QIFDSQRGCD LSISVNVQGE DALGFCGHTV ILTANLEAQA  60
   61 LWKEPGSNVT MSVDAECVPM VRDLLRYFYS RRIDITLSSV KCFHKLASAY GA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.09691
Match: 2nn2A
Description: No description for 2nn2A was found.

Predicted Domain #3
Region A:
Residues: [237-360]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQLQGYCASL FAILLPQDPS FQMPLDLYAY AVATGDALLE KLCLQFLAWN FEALTQAEAW  60
   61 PSVPTDLLQL LLPRSDLAVP SELALLKAVD TWSWGERASH EEVEGLVEKI RFPMMLPEEL 120
  121 FELQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.0
Match: 2eqxA
Description: No description for 2eqxA was found.

Predicted Domain #4
Region A:
Residues: [361-511]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT EDTYKPRIYT SPTWSAFVTD  60
   61 SSWSARKSQL VYQSRRGPLV KYSSDYFQAP SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL 120
  121 VYLPTIQSCW NYGFSCSSDE LPVLGLTKSG G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1x2jA
Description: Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [512-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDRTIAYENK ALMLCEGLFV ADVTDFEGWK AAIPSALDTN SSKSTSSFPC PAGHFNGFRT  60
   61 VIRPFYLTNS SGVD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle