YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|119571719, gi...
Organism:	Homo sapiens
Length:	1371 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|119571719, gi....

Description	E-value	Query Range	Subject Range
gi\|114599987 - gi\|114599987\|ref\|XP_001162804.1\| PREDICTED: ERBB2 interacting protein isoform 4 [Pan troglodytes]	0.0	[1..1371]	[1..1371]
gi\|92098125 - gi\|92098125\|gb\|AAI15013.1\| Erbb2 interacting protein [Homo sapiens]	0.0	[1..1371]	[1..1371]
gi\|54607112 - gi\|54607112\|ref\|NP_067538.2\| Erbb2 interacting protein isoform 2 [Mus musculus]	0.0	[1..1371]	[1..1376]
gi\|76646273 - gi\|76646273\|ref\|XP_880152.1\| PREDICTED: similar to ERBB2 interacting protein isoform 2 isoform 9 [Bo...	0.0	[1..1371]	[1..1372]

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Predicted Domain #1

Region A:
Residues: [1-571]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTKRSLFVR LVPCRCLRGE EETVTTLDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE  60
   61 LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLTIV 120
  121 EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM 180
  181 NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDANRLT FIPGFIGSLK QLTYLDVSKN 240
  241 NIEMVEEGIS TCENLQDLLL SSNSLQQLPE TIGSLKNITT LKIDENQLMY LPDSIGGLIS 300
  301 VEELDCSFNE VEALPSSIGQ LTNLRTFAAD HNYLQQLPPE IGSWKNITVL FLHSNKLETL 360
  361 PEEMGDMQKL KVINLSDNRL KNLPFSFTKL QQLTAMWLSD NQSKPLIPLQ KETDSETQKM 420
  421 VLTNYMFPQQ PRTEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL 480
  481 KRYPTPYPDE LKNMVKTVQT IVHRLKDEET NEDSGRDLKP HEDQQDINKD VGVKTSESTT 540
  541 TVKSKVDERE KYMIGNSVQK ISEPEAEISP G

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.69897
Match:	1ziwA
Description:	Human Toll-like Receptor 3 extracellular domain structure
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [572-712]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLPVTANMKA SENLKHIVNH DDVFEESEEL SSDEEMKMAE MRPPLIETSI NQPKVVALSN  60
   61 NKKDDTKETD SLSDEVTHNS NQNNSNCSSP SRMSDSVSLN TDSSQDTSLC SPVKQTHIDI 120
  121 NSKIRQEDEN FNSLLQNGDI L

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [713-842]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSTEEKFKA HDKKDFNLPE YDLNVEERLV LIEKSVDSTA TADDTHKLDH INMNLNKLIT  60
   61 NDTFQPEIME RSKTQDIVLG TSFLSINSKE ETEHLENGNK YPNLESVNKV NGHSEETSQS 120
  121 PNRTEPHDSD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.154902
Match:	1kohA
Description:	mRNA export factor tap
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [843-995]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CSVDLGISKS TEDLSPQKSG PVGSVVKSHS ITNMEIGGLK IYDILSDNGP QQPSTTVKIT  60
   61 SAVDGKNIVR SKSATLLYDQ PLQVFTGSSS SSDLISGTKA IFKFDSNHNP EEPNIIRGPT 120
  121 SGPQSAPQIY GPPQYNIQYS SSAAVKDTLW HSK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [996-1128]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNPQIDHASF PPQLLPRSES TENQSYAKHS ANMNFSNHNN VRANTAYHLH QRLGPARHGE  60
   61 MWAISPNDRL IPAVTRSTIQ RQSSVSSTAS VNLGDPGSTR RAQIPEGDYL SYREFHSAGR 120
  121 TPPMMPGSQR PLS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.0
Match:	1uewA
Description:	Solution Structure of The forth PDZ Domain of Human Atrophin-1 Interacting Protein 1 (KIAA0705 Protein)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
cytoskeletal protein binding	3.60106431937699	bayes_pls_golite062009
structural constituent of muscle	3.42559406638725	bayes_pls_golite062009
binding	3.2595117613307	bayes_pls_golite062009
actinin binding	2.8541265463155	bayes_pls_golite062009
protein binding	2.35875654816667	bayes_pls_golite062009
receptor binding	2.21437757568292	bayes_pls_golite062009
actin binding	2.13642404399707	bayes_pls_golite062009
alpha-actinin binding	1.19161788092692	bayes_pls_golite062009
transporter activity	1.18978519116375	bayes_pls_golite062009
transmembrane transporter activity	1.07211582292329	bayes_pls_golite062009
signal transducer activity	1.06018756723145	bayes_pls_golite062009
molecular transducer activity	1.06018756723145	bayes_pls_golite062009
PDZ domain binding	0.87883331498113	bayes_pls_golite062009
growth factor activity	0.761026127092133	bayes_pls_golite062009
substrate-specific transporter activity	0.755223974149211	bayes_pls_golite062009
protein domain specific binding	0.64214865642772	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.549085929250683	bayes_pls_golite062009
beta-catenin binding	0.451508822778631	bayes_pls_golite062009
actin filament binding	0.395248867755308	bayes_pls_golite062009
transcription regulator activity	0.387065538161985	bayes_pls_golite062009
active transmembrane transporter activity	0.252733105474942	bayes_pls_golite062009
structural constituent of cytoskeleton	0.182094987832726	bayes_pls_golite062009

Predicted Domain #6

Region A:
Residues: [1129-1276]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARTYSIDGPN ASRPQSARPS INEIPERTMS VSDFNYSRTS PSKRPNARVG SEHSLLDPPG  60
   61 KSKVPRDWRE QVLRHIEAKK LEKMPLSNGQ MGQPLRPQAN YSQIHHPPQA SVARHPSREQ 120
  121 LIDYLMLKVA HQPPYTQPHC SPRQGHEL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [1277-1371]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKQEIRVRVE KDPELGFSIS GGVGGRGNPF RPDDDGIFVT RVQPEGPASK LLQPGDKIIQ  60
   61 ANGYSFINIE HGQAVSLLKT FQNTVELIIV REVSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.221849
Match:	1n7tA
Description:	Erbin
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: