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View Structure Prediction Details

Protein: DMRT3
Organism: Homo sapiens
Length: 472 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DMRT3.

Description E-value Query
Range
Subject
Range
gi|109111690 - gi|109111690|ref|XP_001089961.1| PREDICTED: similar to doublesex and mab-3 related transcription fac...
1.0E-56 [1..472] [1..472]
gi|109459993 - gi|109459993|ref|XP_219926.4| PREDICTED: similar to doublesex and mab-3 related transcription factor...
4.0E-55 [1..472] [196..671]
gi|114623617 - gi|114623617|ref|XP_528515.2| PREDICTED: doublesex and mab-3 related transcription factor 3 [Pan tro...
5.0E-54 [1..472] [1..472]
gi|25992717, gi|... - gi|28893523|ref|NP_796334.1| doublesex and mab-3 related transcription factor 3 [Mus musculus], gi|2...
3.0E-52 [1..472] [1..476]
gi|73946873 - gi|73946873|ref|XP_851515.1| PREDICTED: similar to doublesex and mab-3 related transcription factor ...
3.0E-46 [1..472] [1..475]
gi|54657094 - gi|54657094|gb|EAL35927.1| DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain [Cryptosporidiu...
gi|67597591 - gi|67597591|ref|XP_666157.1| DNA-directed RNA polymerase II largest chain [Cryptosporidium hominis T...
4.0E-39 [117..420] [1536..1840]
gi|3511287, gi|7... - pir||T31670 DNA-directed RNA polymerase (EC 2.7.7.6) II largest chain - Mastigamoeba invertens (frag...
3.0E-37 [124..393] [1429..1686]
gi|12642614 - gi|12642614|gb|AAK00311.1|AF315821_1 DNA-dependent RNA polymerase II largest subunit RPB1 [Monosiga ...
2.0E-35 [65..390] [1416..1742]

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Predicted Domain #1
Region A:
Residues: [1-78]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF KDCTCEKCIL  60
   61 IIERQRVMAA QVALRRQQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.78
Match: 1lpvA
Description: DM domain of Doublesex (dsx)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.89235255944902 bayes_pls_golite062009
DNA binding 0.785095407133447 bayes_pls_golite062009
transcription regulator activity 0.695640165807409 bayes_pls_golite062009
nucleic acid binding 0.657150206978452 bayes_pls_golite062009
transcription factor activity 0.602797151961352 bayes_pls_golite062009
protein binding 0.534934440905544 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [79-184]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANESLESLIP DSLRALPGPP PPGDAVAAPQ PPPASQPSQP QPPRPAAELA AAAALRWTAE  60
   61 PQPGALQAQL AKPDLTEERL GDGKSADNTE VFSDKDTDQR SSPDVA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [185-315]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSKGCFTPES PEIVSVEEGG YAVQKNGGNP ESRPDSPKCH AEQNHLLIEG PSGTVSLPFS  60
   61 LKANRPPLEV LKKIFPNQKP TVLELILKGC GGDLVSAVEV LLSSRSSVTG AERTSAEPES 120
  121 LALPSNGHIF E

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [316-472]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTLSSYPISS SKWSVGSAFR VPDTLRFSAD SSNVVPSPLA GPLQPPFPQP PRYPLMLRNT  60
   61 LARSQSSPFL PNDVTLWNTM TLQQQYQLRS QYVSPFPSNS TSVFRSSPVL PARATEDPRI 120
  121 SIPDDGCPFV SKQSIYTEDD YDERSDSSDS RTLNTSS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle