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View Structure Prediction Details

Protein: HNRNPCL1
Organism: Homo sapiens
Length: 293 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPCL1.

Description E-value Query
Range
Subject
Range
gi|76633747 - gi|76633747|ref|XP_881817.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
7.0E-45 [4..247] [87..334]
gi|109091847 - gi|109091847|ref|XP_001109542.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 [Macaca mulatta]
2.0E-42 [4..247] [87..334]
PABPC1L - poly(A) binding protein, cytoplasmic 1-like
2.0E-42 [4..247] [87..334]

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Predicted Domain #1
Region A:
Residues: [1-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASNVTNKMD PHSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIAGCSVHK GFAFVQYDKE  60
   61 KNARAAVAGE DGRMIASQVV DINLAAEPKV NRGNAGVKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1wf1A
Description: Solution structure of RRM domain in RNA-binding protein NP_057951
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
snRNA binding 3.28448936696877 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
binding 3.05116833253954 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
U1 snRNA binding 2.26303528058407 bayes_pls_golite062009
structural molecule activity 1.29928829870122 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
protein binding 0.42571879933058 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [100-293]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAAEMYGSSF DLDYGFQRDY YDGMYSFPAR VPPPPPIALA VVPSKRQRLS GNTSRRGKSG  60
   61 FNSKSGKRGS SKSGKLKGDD LQAIKQELTQ IKQKVDSLLE NLEKIEKEQS KQEVEVKNAK 120
  121 SEEEQSSSSM KKDETHVKME SEGGAEDSAE EGDPLDDDVN EDQGDDQLEL IKDDEKEAEE 180
  181 GEDDRDSTNG QDDS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle