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View Structure Prediction Details

Protein: OAT
Organism: Homo sapiens
Length: 439 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OAT.

Description E-value Query
Range
Subject
Range
gi|1168056 - gi|1168056|gb|AAB35211.1| ornithine aminotransferase, OAT [human, gyrate atrophy of the choroid and ...
0.0 [1..439] [1..439]
gi|109090867 - gi|109090867|ref|XP_001082811.1| PREDICTED: ornithine aminotransferase isoform 2 [Macaca mulatta]
0.0 [1..439] [1..439]
gi|55729620 - gi|55729620|emb|CAH91539.1| hypothetical protein [Pongo abelii]
gi|197101908 - gi|197101908|ref|NP_001125904.1| ornithine aminotransferase (gyrate atrophy) [Pongo abelii]
0.0 [1..439] [1..439]
gi|53133870, gi|... - gi|57529515|ref|NP_001006567.1| ornithine aminotransferase [Gallus gallus], gi|53133870|emb|CAG32264...
0.0 [1..439] [1..439]
OAT_MOUSE - Ornithine aminotransferase, mitochondrial OS=Mus musculus GN=Oat PE=1 SV=1
0.0 [1..439] [1..439]
OAT_RAT - Ornithine aminotransferase, mitochondrial OS=Rattus norvegicus GN=Oat PE=1 SV=1
0.0 [1..439] [1..439]

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Predicted Domain #1
Region A:
Residues: [1-439]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSKLAHLQR FAVLSRGVHS SVASATSVAT KKTVQGPPTS DDIFEREYKY GAHNYHPLPV  60
   61 ALERGKGIYL WDVEGRKYFD FLSSYSAVNQ GHCHPKIVNA LKSQVDKLTL TSRAFYNNVL 120
  121 GEYEEYITKL FNYHKVLPMN TGVEAGETAC KLARKWGYTV KGIQKYKAKI VFAAGNFWGR 180
  181 TLSAISSSTD PTSYDGFGPF MPGFDIIPYN DLPALERALQ DPNVAAFMVE PIQGEAGVVV 240
  241 PDPGYLMGVR ELCTRHQVLF IADEIQTGLA RTGRWLAVDY ENVRPDIVLL GKALSGGLYP 300
  301 VSAVLCDDDI MLTIKPGEHG STYGGNPLGC RVAIAALEVL EEENLAENAD KLGIILRNEL 360
  361 MKLPSDVVTA VRGKGLLNAI VIKETKDWDA WKVCLRLRDN GLLAKPTHGD IIRFAPPLVI 420
  421 KEDELRESIE IINKTILSF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 113.0
Match: 1oatA
Description: Ornithine aminotransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
4-aminobutyrate transaminase activity 3.63797881096751 bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity 3.359406422625 bayes_pls_golite062009
transferase activity 2.59075614411581 bayes_pls_golite062009
catalytic activity 2.29878871754893 bayes_pls_golite062009
adenosylmethionine-8-amino-7-oxononanoate transaminase activity 1.74778109525713 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor 1.63055151623667 bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity 1.63055151623667 bayes_pls_golite062009
N-succinyltransferase activity 1.52003194822848 bayes_pls_golite062009
N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity 1.4383564662931 bayes_pls_golite062009
glutamate decarboxylase activity 1.34215658716536 bayes_pls_golite062009
transferase activity, transferring nitrogenous groups 1.28316822767388 bayes_pls_golite062009
transaminase activity 1.24990480711889 bayes_pls_golite062009
transferase activity, transferring acyl groups 1.19150094103499 bayes_pls_golite062009
transcription regulator activity 0.977210827616757 bayes_pls_golite062009
nucleic acid binding 0.892872530648552 bayes_pls_golite062009
ligase activity 0.827063849687833 bayes_pls_golite062009
DNA binding 0.803965264969424 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase binding 0.78144409237642 bayes_pls_golite062009
carbon-sulfur lyase activity 0.698312655247044 bayes_pls_golite062009
transcription factor activity 0.597417107954964 bayes_pls_golite062009
5-aminolevulinate synthase activity 0.54326874956263 bayes_pls_golite062009
binding 0.49769115245722 bayes_pls_golite062009
ornithine-oxo-acid transaminase activity 0.311107335626334 bayes_pls_golite062009
N-acyltransferase activity 0.2609065149092 bayes_pls_golite062009
kynureninase activity 0.242752584041108 bayes_pls_golite062009
pyridoxal phosphate binding 0.16957228630576 bayes_pls_golite062009
vitamin B6 binding 0.16957228630576 bayes_pls_golite062009
cystathionine beta-lyase activity 0.15938456446406 bayes_pls_golite062009
methyltransferase activity 0.103986924428507 bayes_pls_golite062009
sulfurtransferase activity 0.0450490929307473 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.0254276656964899 bayes_pls_golite062009

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