YRC Public Data Repository - Protein Structure Prediction

Protein:	CSTB
Organism:	Homo sapiens
Length:	98 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CSTB.

Description	E-value	Query Range	Subject Range
gi\|30584379, gi\|... - gi\|61370525\|gb\|AAX43510.1\| cystatin B [synthetic construct], gi\|61370519\|gb\|AAX43509.1\| cystatin B [...	9.0E-40	[1..98]	[1..98]
CYTB_PANTR - Cystatin-B OS=Pan troglodytes GN=CSTB PE=3 SV=1	3.0E-39	[1..98]	[1..98]
gi\|23821409 - gi\|23821409\|dbj\|BAC21008.1\| cystatin B [Macaca fuscata] gi\|109065176 - gi\|109065176\|ref\|XP_001104524.1\| PREDICTED: cystatin B (stefin B) [Macaca mulatta] CYTB_MACFU - Cystatin-B OS=Macaca fuscata fuscata GN=CSTB PE=3 SV=1	5.0E-39	[1..98]	[1..98]
CYTB_PIG - Cystatin-B OS=Sus scrofa GN=CSTB PE=1 SV=1	1.0E-38	[1..98]	[1..98]
gi\|76608397 - gi\|76608397\|ref\|XP_591975.2\| PREDICTED: similar to Cystatin B (Liver thiol proteinase inhibitor) (CP...	2.0E-38	[3..98]	[133..228]
gi\|494619 - gi\|494619\|pdb\|1STF\|I Chain I, The Refined 2.4 Angstroms X-Ray Crystal Structure Of Recombinant Human...	2.0E-38	[1..98]	[1..98]
gi\|127140962, gi... - gi\|94401232\|ref\|XP_998728.1\| PREDICTED: similar to cystatin A [Mus musculus], gi\|82965740\|ref\|XP_920...	9.0E-38	[1..98]	[1..97]
gi\|109494457 - gi\|109494457\|ref\|XP_001070830.1\| PREDICTED: similar to stefin A2 like 1 [Rattus norvegicus]	1.0E-37	[4..98]	[10..103]

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Predicted Domain #1

Region A:
Residues: [1-98]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG  60
   61 DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	40.0
Match:	1stfI
Description:	Cystatin B (stefin B)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protease binding	3.05816171871392	bayes_pls_golite062009
binding	1.98021211698364	bayes_pls_golite062009
enzyme inhibitor activity	1.95903133061911	bayes_pls_golite062009
enzyme binding	1.4394131270763	bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity	1.22451594457354	bayes_pls_golite062009
protein binding	0.823288035712675	bayes_pls_golite062009
structural molecule activity	0.605570282689207	bayes_pls_golite062009
endopeptidase inhibitor activity	0.502159706024347	bayes_pls_golite062009
enzyme regulator activity	0.479748849334581	bayes_pls_golite062009
peptidase inhibitor activity	0.32828147131654	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: