YRC Public Data Repository - Protein Structure Prediction

Protein:	HNRNPH2
Organism:	Homo sapiens
Length:	449 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HNRNPH2.

Description	E-value	Query Range	Subject Range
gi\|7673355 - gi\|7673355\|gb\|AAF66823.1\|AF190655_1 poly(A)-binding protein [Nicotiana tabacum]	2.0E-60	[11..444]	[27..465]
gi\|19347816 - gi\|19347816\|gb\|AAL86321.1\| putative poly(A)-binding protein [Arabidopsis thaliana]	3.0E-60	[10..444]	[19..458]
gi\|92873940 - gi\|92873940\|gb\|ABE82276.1\| RNA-binding region RNP-1 (RNA recognition motif) [Medicago truncatula]	2.0E-59	[11..444]	[34..472]
gi\|13560783 - gi\|13560783\|gb\|AAK30205.1\|AF349964_1 poly(A)-binding protein [Daucus carota]	1.0E-58	[9..444]	[38..478]
gi\|73976795 - gi\|73976795\|ref\|XP_857656.1\| PREDICTED: similar to Polyadenylate-binding protein 4 (Poly(A)-binding ...	3.0E-58	[1..446]	[1..457]
gi\|7528270 - gi\|7528270\|gb\|AAF63202.1\|AF240679_1 poly(A)-binding protein [Cucumis sativus]	4.0E-58	[11..444]	[29..468]
gi\|76689289 - gi\|76689289\|ref\|XP_881630.1\| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 1 ...	7.0E-58	[1..442]	[1..453]
gi\|82934588, gi\|... - gi\|82934588\|ref\|XP_484034.3\| PREDICTED: similar to poly(A) binding protein, cytoplasmic 4 isoform 1 ...	8.0E-58	[1..442]	[1..451]

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Predicted Domain #1

Region A:
Residues: [1-107]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLSTEGREG FVVKVRGLPW SCSADEVMRF FSDCKIQNGT SGIRFIYTRE GRPSGEAFVE  60
   61 LESEEEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT GPNSPDT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.522879
Match:	2db1A
Description:	No description for 2db1A was found.

Predicted Domain #2

Region A:
Residues: [108-193]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANDGFVRLRG LPFGCSKEEI VQFFSGLEIV PNGMTLPVDF QGRSTGEAFV QFASQEIAEK  60
   61 ALKKHKERIG HRYIEIFKSS RAEVRT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.69897
Match:	1wg5A
Description:	Solution structure of the first RRM domain in heterogeneous nuclear ribonucleoprotein H
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	6.73097473547076	bayes_pls_golite062009
mRNA binding	5.29759606920196	bayes_pls_golite062009
nucleic acid binding	4.92126426323641	bayes_pls_golite062009
	4.67888641618755	bayes_pls_golite062009
binding	3.64400841800969	bayes_pls_golite062009
poly-pyrimidine tract binding	3.11990160533699	bayes_pls_golite062009
single-stranded RNA binding	2.93798024346416	bayes_pls_golite062009
transcription regulator activity	1.92450390013691	bayes_pls_golite062009
DNA binding	1.8021593476478	bayes_pls_golite062009
snRNA binding	1.76821382294389	bayes_pls_golite062009
structural molecule activity	1.29928829870122	bayes_pls_golite062009
transcription factor activity	1.15127506309683	bayes_pls_golite062009
protein binding	1.12215421354121	bayes_pls_golite062009
U1 snRNA binding	0.612226940931031	bayes_pls_golite062009
mRNA 3'-UTR binding	0.591700155096213	bayes_pls_golite062009
sequence-specific DNA binding	0.383589644462932	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [194-297]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYDPPRKLMA MQRPGPYDRP GAGRGYNSIG RGAGFERMRR GAYGGGYGGY DDYGGYNDGY  60
   61 GFGSDRFGRD LNYCFSGMSD HRYGDGGSSF QSTTGHCVHM RGLP

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.13
Match:	1jchA
Description:	Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [298-449]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YRATENDIYN FFSPLNPMRV HIEIGPDGRV TGEADVEFAT HEDAVAAMAK DKANMQHRYV  60
   61 ELFLNSTAGT SGGAYDHSYV ELFLNSTAGA SGGAYGSQMM GGMGLSNQSS YGGPASQQLS 120
  121 GGYGGGYGGQ SSMSGYDQVL QENSSDYQSN LA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.69897
Match:	2hgnA
Description:	No description for 2hgnA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: