YRC Public Data Repository - Protein Structure Prediction

Protein:	LGALS7
Organism:	Homo sapiens
Length:	136 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LGALS7.

Description	E-value	Query Range	Subject Range
LEG4_RAT - Galectin-4 OS=Rattus norvegicus GN=Lgals4 PE=1 SV=1	4.0E-42	[2..134]	[15..148]
gi\|130502092, gi... - gi\|5882169\|gb\|AAD55242.1\|AF091738_1 galectin-4 [Oryctolagus cuniculus], gi\|130502092\|ref\|NP_00107618...	9.0E-42	[2..134]	[15..148]
gi\|109124625 - gi\|109124625\|ref\|XP_001083444.1\| PREDICTED: lectin, galactoside-binding, soluble, 7 (galectin 7) [Ma...	1.0E-41	[1..136]	[1..136]
LEG4_MOUSE - Galectin-4 OS=Mus musculus GN=Lgals4 PE=1 SV=2 gi\|123253370, gi... - gi\|123253370\|gb\|ABM74073.1\| galectin-4 [Mus spretus], gi\|123253360\|gb\|ABM74072.1\| galectin-4 [Mus sp... gi\|123253350 - gi\|123253350\|gb\|ABM74071.1\| galectin-4 [Mus musculus domesticus] gi\|123253334 - gi\|123253334\|gb\|ABM74070.1\| galectin-4 [Mus musculus castaneus]	2.0E-41	[2..134]	[15..148]
gi\|73948388 - gi\|73948388\|ref\|XP_855387.1\| PREDICTED: similar to Galectin-4 (Lactose-binding lectin 4) (L-36 lacto...	3.0E-41	[2..134]	[62..195]
gi\|61371621, gi\|... - gi\|61371627\|gb\|AAX43702.1\| lectin galactoside-binding soluble 4 [synthetic construct], gi\|61371621\|g...	4.0E-41	[2..134]	[15..148]
gi\|60655029, gi\|... - gi\|60655029\|gb\|AAX32078.1\| lectin galactoside-binding soluble 4 [synthetic construct], gi\|60655027\|g... LGALS4 - lectin, galactoside-binding, soluble, 4	5.0E-41	[2..134]	[15..148]

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Predicted Domain #1

Region A:
Residues: [1-136]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH FNPRLDTSEV  60
   61 VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA VVGDAQYHHF RHRLPLARVR 120
  121 LVEVGGDVQL DSVRIF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.09691
Match:	1bkzA
Description:	S-lectin, different isoforms
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
sugar binding	3.34064405064299	bayes_pls_golite062009
glycosaminoglycan binding	2.70103238455595	bayes_pls_golite062009
binding	2.40096962515027	bayes_pls_golite062009
polysaccharide binding	2.35851723238763	bayes_pls_golite062009
monosaccharide binding	2.09529521879228	bayes_pls_golite062009
carbohydrate binding	1.90829797790335	bayes_pls_golite062009
protein binding	1.80794638640093	bayes_pls_golite062009
heparin binding	1.60966215355794	bayes_pls_golite062009
extracellular matrix binding	1.41229380365824	bayes_pls_golite062009
fibronectin binding	1.10309233016451	bayes_pls_golite062009
galactoside binding	1.08479183125487	bayes_pls_golite062009
pattern binding	0.969915174528009	bayes_pls_golite062009
receptor binding	0.9012250808046	bayes_pls_golite062009
extracellular matrix structural constituent	0.5068011550246	bayes_pls_golite062009
transcription regulator activity	0.372701974560119	bayes_pls_golite062009
nucleic acid binding	0.216086300988177	bayes_pls_golite062009
DNA binding	0.157628282318248	bayes_pls_golite062009
growth factor activity	0.119475011376319	bayes_pls_golite062009
fibroblast growth factor 2 binding	0.0714976455077903	bayes_pls_golite062009
fibrinogen binding	0.0714976455077903	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: