YRC Public Data Repository - Protein Structure Prediction

Protein:	NOB1
Organism:	Homo sapiens
Length:	412 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NOB1.

Description	E-value	Query Range	Subject Range
gi\|55644155 - gi\|55644155\|ref\|XP_523405.1\| PREDICTED: nin one binding protein isoform 2 [Pan troglodytes]	0.0	[1..412]	[1..412]
NOB1_PONPY - RNA-binding protein NOB1 - Pongo pygmaeus (Orangutan) NOB1_PONAB - RNA-binding protein NOB1 OS=Pongo abelii GN=NOB1 PE=2 SV=1	0.0	[1..412]	[1..411]
NOB1_BOVIN - RNA-binding protein NOB1 OS=Bos taurus GN=NOB1 PE=2 SV=1	0.0	[1..412]	[1..413]
gi\|109129054 - gi\|109129054\|ref\|XP_001101319.1\| PREDICTED: similar to nin one binding protein [Macaca mulatta]	0.0	[1..412]	[1..412]
NOB1_MACFA - RNA-binding protein NOB1 OS=Macaca fascicularis GN=NOB1 PE=2 SV=1	0.0	[1..412]	[1..412]
NOB1_MOUSE - RNA-binding protein NOB1 OS=Mus musculus GN=Nob1 PE=1 SV=1	0.0	[1..412]	[1..403]
NOB1_RAT - RNA-binding protein NOB1 OS=Rattus norvegicus GN=Nob1 PE=2 SV=1	0.0	[1..412]	[1..410]

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Predicted Domain #1

Region A:
Residues: [1-170]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPVEHVVAD AGAFLRHAAL QDIGKNIYTI REVVTEIRDK ATRRRLAVLP YELRFKEPLP  60
   61 EYVRLVTEFS KKTGDYPSLS ATDIQVLALT YQLEAEFVGV SHLKQEPQKV KVSSSIQHPE 120
  121 TPLHISGFHL PYKPKPPQET EKGHSACEPE NLEFSSFMFW RNPLPNIDHE

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.41
Match:	1o4wA
Description:	Hypothetical protein AF0591
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nuclease activity	2.49612885073648	bayes_pls_golite062009
exonuclease activity	2.20856194655683	bayes_pls_golite062009
DNA binding	1.98330542087379	bayes_pls_golite062009
binding	1.91435224223408	bayes_pls_golite062009
nucleic acid binding	1.86243238793767	bayes_pls_golite062009
endodeoxyribonuclease activity	1.74349203224875	bayes_pls_golite062009
deoxyribonuclease activity	1.68760157046614	bayes_pls_golite062009
endonuclease activity	1.2840172881923	bayes_pls_golite062009
catalytic activity	1.27951740231695	bayes_pls_golite062009
flap endonuclease activity	1.17726395799783	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1.07360773846975	bayes_pls_golite062009
5'-3' exonuclease activity	0.974028111038185	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.867731336605067	bayes_pls_golite062009
hydrolase activity	0.827276601361763	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.79417076649627	bayes_pls_golite062009
protein binding	0.695466920831325	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.267787854683683	bayes_pls_golite062009
exodeoxyribonuclease activity	0.260397221344929	bayes_pls_golite062009
3'-5' exonuclease activity	0.175191448555725	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [171-236]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQELLIDRGE DVPSEEEEEE ENGFEDRKDD SDDDGGGWIT PSNIKQIQQE LEQCDVPEDV  60
   61 RVGCLT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [237-326]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDFAMQNVLL QMGLHVLAVN GMLIREARSY ILRCHGCFKT TSDMSRVFCS HCGNKTLKKV  60
   61 SVTVSDDGTL HMHFSRNPKV LNPRGLRYSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.30103
Match:	2conA
Description:	Solution Structure of RSGI RUH-035, a Zn-ribbon module in Mouse cDNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA binding	2.67504868533195	bayes_pls_golite062009
binding	2.1226043957694	bayes_pls_golite062009
nucleic acid binding	1.26170105245043	bayes_pls_golite062009
protein binding	0.874974846355882	bayes_pls_golite062009
catalytic activity	0.316629025709297	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [327-412]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTPKGGKYAI NPHLTEDQRF PQLRLSQKAR QKTNVFAPDY IAGVSPFVEN DISSRSATLQ  60
   61 VRDSTLGAGR RRLNPNASRK KFVKKR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: