YRC Public Data Repository - Protein Structure Prediction

Protein:	TNFSF4
Organism:	Homo sapiens
Length:	183 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TNFSF4.

Description	E-value	Query Range	Subject Range
gi\|114565479 - gi\|114565479\|ref\|XP_001148146.1\| PREDICTED: tumor necrosis factor (ligand) superfamily, member 4 iso...	3.0E-89	[1..183]	[1..183]
gi\|109019538 - gi\|109019538\|ref\|XP_001101190.1\| PREDICTED: tumor necrosis factor (ligand) superfamily, member 4 (ta... CCDS1306.1_1 - null	3.0E-89	[1..183]	[1..183]
gi\|49457019 - gi\|49457019\|emb\|CAG46830.1\| TNFSF4 [Homo sapiens] gi\|60822990 - gi\|60822990\|gb\|AAX36628.1\| tumor necrosis factor superfamily member 4 [synthetic construct]	6.0E-89	[1..183]	[1..183]
gi\|54696146, gi\|... - gi\|61367895\|gb\|AAX43063.1\| tumor necrosis factor superfamily member 4 [synthetic construct], gi\|5469...	6.0E-89	[1..183]	[1..183]
TNFL4_RABIT - Tumor necrosis factor ligand superfamily member 4 OS=Oryctolagus cuniculus GN=TNFSF4 PE=2 SV=1	9.0E-86	[1..181]	[1..185]
TNFL4_RAT - Tumor necrosis factor ligand superfamily member 4 OS=Rattus norvegicus GN=Tnfsf4 PE=2 SV=1	2.0E-85	[2..181]	[4..184]
gi\|151556674, gi... - gi\|157169958\|gb\|AAI53121.1\| Tumor necrosis factor (ligand) superfamily, member 4 [synthetic construc... TNFL4_MOUSE - Tumor necrosis factor ligand superfamily member 4 OS=Mus musculus GN=Tnfsf4 PE=1 SV=1	3.0E-85	[2..181]	[4..183]
gi\|76668251 - gi\|76668251\|ref\|XP_589595.2\| PREDICTED: similar to tumor necrosis factor receptor superfamily, membe...	2.0E-77	[1..182]	[1..181]
gi\|57089417 - gi\|57089417\|ref\|XP_547459.1\| PREDICTED: similar to Tumor necrosis factor ligand superfamily member 4...	1.0E-76	[1..181]	[1..181]
gi\|68534966, gi\|... - gi\|68534966\|ref\|NP_001020388.1\| tumor necrosis factor receptor superfamily, member 4 [Sus scrofa], g...	1.0E-74	[1..182]	[1..181]

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Predicted Domain #1

Region A:
Residues: [1-183]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERVQPLEEN VGNAARPRFE RNKLLLVASV IQGLGLLLCF TYICLHFSAL QVSHRYPRIQ  60
   61 SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF YLISLKGYFS QEVNISLHYQ 120
  121 KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF 180
  181 CVL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	61.39794
Match:	2hevF
Description:	No description for 2hevF was found.

Predicted functions:

Term	Confidence	Notes
tumor necrosis factor receptor binding	4.97032095500332	bayes_pls_golite062009
tumor necrosis factor receptor superfamily binding	2.83043724362524	bayes_pls_golite062009
receptor binding	2.30826967264465	bayes_pls_golite062009
protein binding	2.25413201891408	bayes_pls_golite062009
CD40 receptor binding	1.92939268560534	bayes_pls_golite062009
binding	1.55055236820725	bayes_pls_golite062009
cell surface binding	1.54737106887049	bayes_pls_golite062009
eukaryotic cell surface binding	1.02834426035531	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: