YRC Public Data Repository - Protein Structure Prediction

Protein:	SEC23IP
Organism:	Homo sapiens
Length:	1000 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SEC23IP.

Description	E-value	Query Range	Subject Range
gi\|114633054 - gi\|114633054\|ref\|XP_508076.2\| PREDICTED: Sec23-interacting protein p125 isoform 2 [Pan troglodytes]	0.0	[1..1000]	[1..1000]
gi\|55730144 - gi\|55730144\|emb\|CAH91796.1\| hypothetical protein [Pongo abelii] gi\|197101457 - gi\|197101457\|ref\|NP_001127463.1\| SEC23 interacting protein [Pongo abelii]	0.0	[1..1000]	[30..1028]
gi\|109090759 - gi\|109090759\|ref\|XP_001100615.1\| PREDICTED: Sec23-interacting protein p125 isoform 3 [Macaca mulatta...	0.0	[1..1000]	[1..1000]
gi\|73998720 - gi\|73998720\|ref\|XP_535037.2\| PREDICTED: similar to SEC23-interacting protein (p125) isoform 2 [Canis...	0.0	[1..1000]	[1..1003]
gi\|109462958, gi... - gi\|198442887\|ref\|NP_001128331.1\| SEC23 interacting protein [Rattus norvegicus], gi\|149067610\|gb\|EDM1...	0.0	[1..1000]	[1..999]
gi\|76673295 - gi\|76673295\|ref\|XP_878339.1\| PREDICTED: similar to SEC23-interacting protein (p125) isoform 6 [Bos t...	0.0	[1..1000]	[1..1006]
S23IP_MOUSE - SEC23-interacting protein OS=Mus musculus GN=Sec23ip PE=1 SV=2	0.0	[1..1000]	[1..998]

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Predicted Domain #1

Region A:
Residues: [1-374]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAERKPNGGS GGASTSSSGT NLLFSSSATE FSFNVPFIPV TQASASPASL LLPGEDSTDV  60
   61 GEEDSFLGQT SIHTSAPQTF SYFSQVSSSS DPFGNIGQSP LTTAATSVGQ SGFPKPLTAL 120
  121 PFTTGSQDVS NAFSPSISKA QPGAPPSSLM GINSYLPSQP SSLPPSYFGN QPQGIPQPGY 180
  181 NPYRHTPGSS RANPYIAPPQ LQQCQTPGPP AHPPPSGPPV QMYQMPPGSL PPVPSSVQSP 240
  241 AQQQVPARPG APSVQVPSPF LLQNQYEPVQ PHWFYCKEVE YKQLWMPFSV FDSLNLEEIY 300
  301 NSVQPDPESV VLGTDGGRYD VYLYDRIRKA AYWEEEPAEV RRCTWFYKGD TDSRFIPYTE 360
  361 EFSEKLEAEY KKAV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.69897
Match:	1y0fA
Description:	No description for 1y0fA was found.

Predicted Domain #2

Region A:
Residues: [375-459]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTNQWHRRLE FPSGETIVMH NPKVIVQFQP SSVPDEWGTT QDGQTRPRVV KRGIDDNLDE  60
   61 IPDGEMPQVD HLVFVVHGIG PVCDL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	9.522879
Match:	1ul7A
Description:	Solution structure of kinase associated domain 1 of mouse MAP/microtubule affinity-regulating kinase 3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.62955416667198	bayes_pls_golite062009
protein serine/threonine kinase activity	0.948847910276381	bayes_pls_golite062009
protein binding	0.911727732150777	bayes_pls_golite062009
catalytic activity	0.293538501560182	bayes_pls_golite062009
ATP binding	0.26935413682411	bayes_pls_golite062009
adenyl ribonucleotide binding	0.240660657655502	bayes_pls_golite062009
adenyl nucleotide binding	0.236006384312529	bayes_pls_golite062009
purine nucleotide binding	0.234121269075782	bayes_pls_golite062009
ribonucleotide binding	0.230186899198459	bayes_pls_golite062009
purine ribonucleotide binding	0.230144903720081	bayes_pls_golite062009
nucleotide binding	0.226056374465577	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0736099081095881	bayes_pls_golite062009
kinase activity	0.0280132346880262	bayes_pls_golite062009
protein kinase activity	0.016719885205046	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [460-621]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RFRSIIECVD DFRVVSLKLL RTHFKKSLDD GKVSRVEFLP VHWHSSLGGD ATGVDRNIKK  60
   61 ITLPSIGRFR HFTNETLLDI LFYNSPTYCQ TIVEKVGMEI NHLHALFMSR NPDFKGGVSV 120
  121 AGHSLGSLIL FDILSNQKDL NLSKCPGPLA VANGVVKQLH FQ

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	0.961
Match:	2czqA
Description:	No description for 2czqA was found.

Predicted Domain #4

Region A:
Residues: [622-706]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKQMPEEPKL TLDESYDLVV ENKEVLTLQE TLEALSLSEY FSTFEKEKID MESLLMCTVD  60
   61 DLKEMGIPLG PRKKIANFVE HKAAK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.522879
Match:	2f3nA
Description:	Crystal Structure of the native Shank SAM domain.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.53905184151408	bayes_pls_golite062009
protein binding	2.33652613087799	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [707-823]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKKAASEKKA VAATSTKGQE QSAQKTKDMA SLPSESNEPK RKLPVGACVS SVCVNYESFE  60
   61 VGAGQVSVAY NSLDFEPEIF FALGSPIAMF LTIRGVDRID ENYSLPTCKG FFNIYHP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [824-1000]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDPVAYRLEP MIVPDLDLKA VLIPHHKGRK RLHLELKESL SRMGSDLKQG FISSLKSAWQ  60
   61 TLNEFARAHT SSTQLQEELE KVANQIKEEE EKQVVEAEKV VESPDFSKDE DYLGKVGMLN 120
  121 GGRRIDYVLQ EKPIESFNEY LFALQSHLCY WESEDTALLL LKEIYRTMNI SPEQPQH

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: