YRC Public Data Repository - Protein Structure Prediction

Protein:	PIGK
Organism:	Homo sapiens
Length:	395 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PIGK.

Description	E-value	Query Range	Subject Range
gi\|54035423, gi\|... - gi\|58865476\|ref\|NP_001011953.1\| phosphatidylinositol glycan anchor biosynthesis, class K [Rattus nor...	0.0	[1..395]	[1..395]
gi\|114557239 - gi\|114557239\|ref\|XP_001168438.1\| PREDICTED: phosphatidylinositol glycan anchor biosynthesis, class K... sp\|Q92643\|GPI8_H... - GPI-anchor transamidase OS=Homo sapiens GN=PIGK PE=1 SV=2 VAR_051518, GPI-anchor transamidase OS=Hom...	0.0	[1..395]	[1..395]
GPI8_PONPY - GPI-anchor transamidase precursor - Pongo pygmaeus (Orangutan) GPI8_PONAB - GPI-anchor transamidase OS=Pongo abelii GN=PIGK PE=2 SV=1	0.0	[1..395]	[1..395]
gi\|1518259 - gi\|1518259\|emb\|CAA68871.1\| gpi8 [Homo sapiens]	0.0	[6..395]	[7..396]
GPI8_MOUSE - GPI-anchor transamidase OS=Mus musculus GN=Pigk PE=1 SV=2	0.0	[1..395]	[1..395]
gi\|73959812 - gi\|73959812\|ref\|XP_853775.1\| PREDICTED: similar to GPI-anchor transamidase precursor (GPI transamida...	0.0	[9..395]	[10..396]
gi\|109008530 - gi\|109008530\|ref\|XP_001102474.1\| PREDICTED: phosphatidylinositol glycan, class K [Macaca mulatta]	0.0	[1..395]	[1..395]
GPI8_BOVIN - GPI-anchor transamidase OS=Bos taurus GN=PIGK PE=2 SV=1	0.0	[1..395]	[1..395]
GPI8_PIG - GPI-anchor transamidase OS=Sus scrofa GN=PIGK PE=2 SV=1	0.0	[1..395]	[1..395]

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Predicted Domain #1

Region A:
Residues: [1-307]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVTDSLSRA ATVLATVLLL SFGSVAASHI EDQAEQFFRS GHTNNWAVLV CTSRFWFNYR  60
   61 HVANTLSVYR SVKRLGIPDS HIVLMLADDM ACNPRNPKPA TVFSHKNMEL NVYGDDVEVD 120
  121 YRSYEVTVEN FLRVLTGRIP PSTPRSKRLL SDDRSNILIY MTGHGGNGFL KFQDSEEITN 180
  181 IELADAFEQM WQKRRYNELL FIIDTCQGAS MYERFYSPNI MALASSQVGE DSLSHQPDPA 240
  241 IGVHLMDRYT FYVLEFLEEI NPASQTNMND LFQVCPKSLC VSTPGHRTDL FQRDPKNVLI 300
  301 TDFFGSV

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.64
Match:	1m72A
Description:	Crystal Structure of Caspase-1 from Spodoptera frugiperda
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein binding	1.91027458364943	bayes_pls_golite062009
binding	1.79991239685564	bayes_pls_golite062009
peptidase activity	1.03949773191901	bayes_pls_golite062009
catalytic activity	0.976874866811795	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.690246965666701	bayes_pls_golite062009
cysteine-type peptidase activity	0.5642733654889	bayes_pls_golite062009
endopeptidase activity	0.373000256936384	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [308-395]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKVEITTETI KLQQDSEIME SSYKEDQMDE KLMEPLKYAE QLPVAQIIHQ KPKLKDWHPP  60
   61 GGFILGLWAL IIMVFFKTYG IKHMKFIF

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: