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View Structure Prediction Details

Protein: PIP5K1A
Organism: Homo sapiens
Length: 562 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PIP5K1A.

Description E-value Query
Range
Subject
Range
gi|114559340 - gi|114559340|ref|XP_001170201.1| PREDICTED: phosphatidylinositol-4-phosphate 5-kinase, type I, alpha...
0.0 [18..562] [18..562]
gi|109016155 - gi|109016155|ref|XP_001105608.1| PREDICTED: phosphatidylinositol-4-phosphate 5-kinase, type I, alpha...
0.0 [18..562] [18..562]
gi|1743871, gi|5... - gi|55960957|emb|CAI16387.1| phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [Homo sapiens],...
0.0 [18..562] [18..549]
gi|110835721 - gi|110835721|ref|NP_001036086.1| phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [Rattus no...
0.0 [14..562] [13..546]

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Predicted Domain #1
Region A:
Residues: [1-449]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI SLVPYASGMP  60
   61 IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL STKPERDVLM QDFYVVESIF 120
  121 FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF RELFGIRPDD YLYSLCSEPL IELCSSGASG 180
  181 SLFYVSSDDE FIIKTVQHKE AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR 240
  241 IVVMNNLLPR SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM 300
  301 YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT RRPAPQKALY 360
  361 STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI GIIDILQSYR FVKKLEHSWK 420
  421 ALVHDGDTVS VHRPGFYAER FQRFMCNTV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 115.0
Match: 1bo1A
Description: Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
inositol or phosphatidylinositol kinase activity 4.31726963575315 bayes_pls_golite062009
lipid kinase activity 3.63026201392483 bayes_pls_golite062009
phosphatidylinositol phosphate kinase activity 3.29315211323714 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.8512866333787 bayes_pls_golite062009
kinase activity 2.68971389233526 bayes_pls_golite062009
1-phosphatidylinositol-4-phosphate 5-kinase activity 2.65186975336776 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.31077377326314 bayes_pls_golite062009
catalytic activity 1.87792712964225 bayes_pls_golite062009
binding 1.23659721062619 bayes_pls_golite062009
transferase activity 1.20817067352467 bayes_pls_golite062009
ligase activity 0.435608917599349 bayes_pls_golite062009
protein kinase activity 0.422676745032915 bayes_pls_golite062009
protein binding 0.382966234080422 bayes_pls_golite062009
protein serine/threonine kinase activity 0.189737258618863 bayes_pls_golite062009
acid-amino acid ligase activity 0.14608192065514 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [450-562]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FKKIPLKPSP SKKFRSGSSF SRRAGSSGNS CITYQPSVSG EHKAQVTTKA EVEPGVHLGR  60
   61 PDVLPQTPPL EEISEGSPIP DPSFSPLVGE TLQMLTTSTT LEKLEVAESE FTH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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