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View Structure Prediction Details

Protein: gi|2827205, gi|4...
Organism: Homo sapiens
Length: 977 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|2827205, gi|4....

Description E-value Query
Range
Subject
Range
gi|71533987 - gi|71533987|gb|AAH99907.1| General transcription factor II, i [Homo sapiens]
0.0 [1..977] [1..976]
gi|114614017 - gi|114614017|ref|XP_001151565.1| PREDICTED: general transcription factor II, i isoform 6 [Pan troglo...
0.0 [1..977] [1..977]
gi|73957639 - gi|73957639|ref|XP_856738.1| PREDICTED: similar to general transcription factor II, i isoform 3 isof...
0.0 [1..977] [1..978]
GTF2I_BOVIN - General transcription factor II-I OS=Bos taurus GN=GTF2I PE=2 SV=1
0.0 [1..977] [1..978]
gi|109066342 - gi|109066342|ref|XP_001083724.1| PREDICTED: similar to general transcription factor II, i isoform 4 ...
0.0 [1..977] [1..957]

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Predicted Domain #1
Region A:
Residues: [1-18]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQVAMSTLP VEDEESSE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [19-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRMVVTFLMS ALESMCKELA KSKAEVACIA VYETDVFVVG TERGRAFVNT RKDFQKDFVK  60
   61 YCV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [82-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEEKAAEMH KMKSTTQANR MSVDAVEIET LRKTVEDYFC FCYGKALGKS TVVPVPYEKM  60
   61 LRDQSAVVVQ GLPEGVAFKH PENYDLATLK WILENKAGIS FIIKRPFLEP KKHVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.0
Match: 2d9bA
Description: No description for 2d9bA was found.

Predicted Domain #4
Region A:
Residues: [197-316]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRVMVTDADR SILSPGGSCG PIKVKTEPTE DSGISLEMAA VTVKEESEDP DYYQYNIQAG  60
   61 PSETDDVDEK QPLSKPLQGS HHSSEGNEGT EMEVPAEDDD YSPPSKRPKA NELPQPPVPE 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [317-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PANAGKRKVR EFNFEKWNAR ITDLRKQVEE LFERKYAQAI KAKGPVTIPY PLFQSHVEDL  60
   61 YVEGLPEGIP FRRPSTYGIP RLERILLAKE RIRFVIKKHE LLNSTREDLQ LDKPASGVKE 120
  121 EWYARITKLR KMVDQLFCKK FAEALGSTEA KA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.09691
Match: 2dn4A
Description: No description for 2dn4A was found.

Predicted Domain #6
Region A:
Residues: [469-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPYQKFEAHP NDLYVEGLPE NIPFRSPSWY GIPRLEKIIQ VGNRIKFVIK RPELLTHSTT  60
   61 EVTQPRTNTP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [539-654]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKEDWNVRIT KLRKQVEEIF NLKFAQALGL TEAVKVPYPV FESNPEFLYV EGLPEGIPFR  60
   61 SPTWFGIPRL ERIVRGSNKI KFVVKKPELV ISYLPPGMAS KINTKALQSP KRPRSP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.51
Match: 2dzqA
Description: No description for 2dzqA was found.

Predicted Domain #8
Region A:
Residues: [655-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSNSKVPEIE VTVEGPNNNN PQTSAVRTPT QTNGSNVPFK PRGREFSFEA WNAKITDLKQ  60
   61 KVENLFNEKC GEALGLKQAV KVPFALFESF PEDFYVEGLP EGVPFRRPST FGIPRLEKIL 120
  121 RNKAKIKFII KKPEMFETAI KESTSSKSPP RKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.39794
Match: 1q60A
Description: Solution Structure of RSGI RUH-004, a GTF2I domain in Mouse cDNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.31986990828723 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 4.02258915980722 bayes_pls_golite062009
DNA binding 4.01598187073916 bayes_pls_golite062009
nucleic acid binding 3.9329721501879 bayes_pls_golite062009
transcription factor activity 3.83217404681534 bayes_pls_golite062009
binding 3.0325775548747 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.76277877142766 bayes_pls_golite062009
protein binding 1.48651016577672 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.91960306002172 bayes_pls_golite062009
mitogen-activated protein kinase binding 0.245342655759921 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [808-977]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSPNVNTTA SGVEDLNIIQ VTIPDDDNER LSKVEKARQL REQVNDLFSR KFGEAIGMGF  60
   61 PVKVPYRKIT INPGCVVVDG MPPGVSFKAP SYLEISSMRR ILDSAEFIKF TVIRPFPGLV 120
  121 INNQLVDQSE SEGPVIQESA EPSQLEVPAT EEIKETDGSS QIKQEPDPTW 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.221849
Match: 2ejeA
Description: No description for 2ejeA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle