YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: gi|2827205, gi|4...
Organism: Homo sapiens
Length: 977 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|2827205, gi|4....

Description E-value Query
Range
Subject
Range
gi|71533987 - gi|71533987|gb|AAH99907.1| General transcription factor II, i [Homo sapiens]
0.0 [1..977] [1..976]
gi|114614017 - gi|114614017|ref|XP_001151565.1| PREDICTED: general transcription factor II, i isoform 6 [Pan troglo...
0.0 [1..977] [1..977]
gi|73957639 - gi|73957639|ref|XP_856738.1| PREDICTED: similar to general transcription factor II, i isoform 3 isof...
0.0 [1..977] [1..978]
GTF2I_BOVIN - General transcription factor II-I OS=Bos taurus GN=GTF2I PE=2 SV=1
0.0 [1..977] [1..978]
gi|109066342 - gi|109066342|ref|XP_001083724.1| PREDICTED: similar to general transcription factor II, i isoform 4 ...
0.0 [1..977] [1..957]

Back

Predicted Domain #1
Region A:
Residues: [1-18]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQVAMSTLP VEDEESSE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [19-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRMVVTFLMS ALESMCKELA KSKAEVACIA VYETDVFVVG TERGRAFVNT RKDFQKDFVK  60
   61 YCV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.788 0.149 transcription factor activity d.88.1 SRF-like
View Download 0.664 0.009 transcription initiation from RNA polymerase II promoter d.57.1 DNA damage-inducible protein DinI
View Download 0.770 N/A N/A d.88.1 SRF-like
View Download 0.628 N/A N/A d.88.1 SRF-like
View Download 0.614 N/A N/A d.88.1 SRF-like

Predicted Domain #3
Region A:
Residues: [82-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEEKAAEMH KMKSTTQANR MSVDAVEIET LRKTVEDYFC FCYGKALGKS TVVPVPYEKM  60
   61 LRDQSAVVVQ GLPEGVAFKH PENYDLATLK WILENKAGIS FIIKRPFLEP KKHVG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.0
Match: 2d9bA
Description: No description for 2d9bA was found.

Predicted Domain #4
Region A:
Residues: [197-316]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GRVMVTDADR SILSPGGSCG PIKVKTEPTE DSGISLEMAA VTVKEESEDP DYYQYNIQAG  60
   61 PSETDDVDEK QPLSKPLQGS HHSSEGNEGT EMEVPAEDDD YSPPSKRPKA NELPQPPVPE 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.228 a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted Domain #5
Region A:
Residues: [317-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PANAGKRKVR EFNFEKWNAR ITDLRKQVEE LFERKYAQAI KAKGPVTIPY PLFQSHVEDL  60
   61 YVEGLPEGIP FRRPSTYGIP RLERILLAKE RIRFVIKKHE LLNSTREDLQ LDKPASGVKE 120
  121 EWYARITKLR KMVDQLFCKK FAEALGSTEA KA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.09691
Match: 2dn4A
Description: No description for 2dn4A was found.

Predicted Domain #6
Region A:
Residues: [469-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPYQKFEAHP NDLYVEGLPE NIPFRSPSWY GIPRLEKIIQ VGNRIKFVIK RPELLTHSTT  60
   61 EVTQPRTNTP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.739 d.109.1 Actin depolymerizing proteins
View Download 0.260 c.23.1 CheY-like
View Download 0.426 c.10.2 L domain-like
View Download 0.373 c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.466 d.199.1 DNA-binding C-terminal domain of the transcription factor MotA

Predicted Domain #7
Region A:
Residues: [539-654]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VKEDWNVRIT KLRKQVEEIF NLKFAQALGL TEAVKVPYPV FESNPEFLYV EGLPEGIPFR  60
   61 SPTWFGIPRL ERIVRGSNKI KFVVKKPELV ISYLPPGMAS KINTKALQSP KRPRSP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.51
Match: 2dzqA
Description: No description for 2dzqA was found.

Predicted Domain #8
Region A:
Residues: [655-807]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSNSKVPEIE VTVEGPNNNN PQTSAVRTPT QTNGSNVPFK PRGREFSFEA WNAKITDLKQ  60
   61 KVENLFNEKC GEALGLKQAV KVPFALFESF PEDFYVEGLP EGVPFRRPST FGIPRLEKIL 120
  121 RNKAKIKFII KKPEMFETAI KESTSSKSPP RKI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.39794
Match: 1q60A
Description: Solution Structure of RSGI RUH-004, a GTF2I domain in Mouse cDNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.31986990828723 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 4.02258915980722 bayes_pls_golite062009
DNA binding 4.01598187073916 bayes_pls_golite062009
nucleic acid binding 3.9329721501879 bayes_pls_golite062009
transcription factor activity 3.83217404681534 bayes_pls_golite062009
binding 3.0325775548747 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.76277877142766 bayes_pls_golite062009
protein binding 1.48651016577672 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.91960306002172 bayes_pls_golite062009
mitogen-activated protein kinase binding 0.245342655759921 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [808-977]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSPNVNTTA SGVEDLNIIQ VTIPDDDNER LSKVEKARQL REQVNDLFSR KFGEAIGMGF  60
   61 PVKVPYRKIT INPGCVVVDG MPPGVSFKAP SYLEISSMRR ILDSAEFIKF TVIRPFPGLV 120
  121 INNQLVDQSE SEGPVIQESA EPSQLEVPAT EEIKETDGSS QIKQEPDPTW 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.221849
Match: 2ejeA
Description: No description for 2ejeA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle