YRC Public Data Repository - Protein Structure Prediction

Protein:	GTF2I
Organism:	Homo sapiens
Length:	998 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GTF2I.

Description	E-value	Query Range	Subject Range
gi\|114614015 - gi\|114614015\|ref\|XP_001151627.1\| PREDICTED: general transcription factor II, i isoform 7 [Pan troglo...	0.0	[1..998]	[1..998]
gi\|73957637 - gi\|73957637\|ref\|XP_848656.1\| PREDICTED: similar to general transcription factor II, i isoform 1 isof...	0.0	[1..998]	[1..999]
gi\|76653752 - gi\|76653752\|ref\|XP_873760.1\| PREDICTED: similar to general transcription factor 2-I; alternative spl...	0.0	[1..998]	[1..999]
gi\|168278136 - gi\|168278136\|dbj\|BAG11046.1\| general transcription factor II-I [synthetic construct] gi\|2827203, gi\|1... - gi\|41472584\|gb\|AAS07462.1\| unknown [Homo sapiens], gi\|2827203\|gb\|AAC08313.1\| general transcription f...	0.0	[1..998]	[1..978]
GTF2I_MOUSE - General transcription factor II-I OS=Mus musculus GN=Gtf2i PE=1 SV=3	0.0	[1..998]	[1..998]

Back

Predicted Domain #1

Region A:
Residues: [1-18]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQVAMSTLP VEDEESSE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [19-81]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRMVVTFLMS ALESMCKELA KSKAEVACIA VYETDVFVVG TERGRAFVNT RKDFQKDFVK  60
   61 YCV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [82-199]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEEKAAEMH KMKSTTQANR MSVDAVEIET LRKTVEDYFC FCYGKALGKS TVVPVPYEKM  60
   61 LRDQSAVVVQ GLPEGVAFKH PENYDLATLK WILENKAGIS FIIKRPFLEP KKHVGGRV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.69897
Match:	2d9bA
Description:	No description for 2d9bA was found.

Predicted Domain #4

Region A:
Residues: [200-300]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTDADRSIL SPGGSCGPIK VKTEPTEDSG ISLEMAAVTV KEESEDPDYY QYNIQAGPSE  60
   61 TDDVDEKQPL SKPLQGSHHS SEGNEGTEME VPAEDSTQHV P

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [301-445]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SETSEDPEVE VTIEDDDYSP PSKRPKANEL PQPPVPEPAN AGKRKVREFN FEKWNARITD  60
   61 LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE 120
  121 RILLAKERIR FVIKKHELLN STRED

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.30103
Match:	2dn4A
Description:	No description for 2dn4A was found.

Predicted Domain #6

Region A:
Residues: [446-562]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQLDKPASGV KEEWYARITK LRKMVDQLFC KKFAEALGST EAKAVPYQKF EAHPNDLYVE  60
   61 GLPENIPFRS PSWYGIPRLE KIIQVGNRIK FVIKRPELLT HSTTEVTQPR TNTPVKE

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	6.42
Match:	2dzqA
Description:	No description for 2dzqA was found.

Predicted Domain #7

Region A:
Residues: [563-664]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DWNVRITKLR KQVEEIFNLK FAQALGLTEA VKVPYPVFES NPEFLYVEGL PEGIPFRSPT  60
   61 WFGIPRLERI VRGSNKIKFV VKKPELVISY LPPGMASKIN TK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.0
Match:	2dn5A
Description:	No description for 2dn5A was found.

Predicted Domain #8

Region A:
Residues: [665-714]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALQSPKRPRS PGSNSKVPEI EVTVEGPNNN NPQTSAVRTP TQTNGSNVPF

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9

Region A:
Residues: [715-828]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPRGREFSFE AWNAKITDLK QKVENLFNEK CGEALGLKQA VKVPFALFES FPEDFYVEGL  60
   61 PEGVPFRRPS TFGIPRLEKI LRNKAKIKFI IKKPEMFETA IKESTSSKSP PRKI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.69897
Match:	1q60A
Description:	Solution Structure of RSGI RUH-004, a GTF2I domain in Mouse cDNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.31986990828723	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	4.02258915980722	bayes_pls_golite062009
DNA binding	4.01598187073916	bayes_pls_golite062009
nucleic acid binding	3.9329721501879	bayes_pls_golite062009
transcription factor activity	3.83217404681534	bayes_pls_golite062009
binding	3.0325775548747	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.76277877142766	bayes_pls_golite062009
protein binding	1.48651016577672	bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding	0.91960306002172	bayes_pls_golite062009
mitogen-activated protein kinase binding	0.245342655759921	bayes_pls_golite062009

Predicted Domain #10

Region A:
Residues: [829-998]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSPNVNTTA SGVEDLNIIQ VTIPDDDNER LSKVEKARQL REQVNDLFSR KFGEAIGMGF  60
   61 PVKVPYRKIT INPGCVVVDG MPPGVSFKAP SYLEISSMRR ILDSAEFIKF TVIRPFPGLV 120
  121 INNQLVDQSE SEGPVIQESA EPSQLEVPAT EEIKETDGSS QIKQEPDPTW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	42.0
Match:	2ejeA
Description:	No description for 2ejeA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: