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View Structure Prediction Details

Protein: NDP
Organism: Homo sapiens
Length: 133 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NDP.

Description E-value Query
Range
Subject
Range
gi|60654453 - gi|60654453|gb|AAX29917.1| Norrie disease pseudoglioma protein [synthetic construct]
2.0E-52 [1..133] [1..133]
gi|55662817, gi|... - gi|55662817|ref|XP_528948.1| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes], gi|1146882...
5.0E-52 [1..133] [1..133]
NDP_BOVIN - Norrin OS=Bos taurus GN=NDP PE=2 SV=1
1.0E-50 [1..133] [1..133]
gi|74007314 - gi|74007314|ref|XP_855261.1| PREDICTED: similar to norrin [Canis familiaris]
2.0E-50 [1..133] [1..133]
gi|442527 - gi|442527|gb|AAB28704.1| Norrie's disease protein [human, blood, Norrie's disease patient, Peptide M...
9.0E-50 [1..127] [1..127]
NDP_MOUSE - Norrin OS=Mus musculus GN=Ndp PE=1 SV=1
gi|149044345, gi... - gi|34933194|ref|XP_343764.1| PREDICTED: similar to Norrin precursor (Norrie disease protein homolog)...
1.0E-48 [1..133] [1..131]
gi|50730089 - gi|50730089|ref|XP_416765.1| PREDICTED: hypothetical protein [Gallus gallus]
2.0E-47 [1..133] [1..133]
gi|47217140 - gi|47217140|emb|CAG02641.1| unnamed protein product [Tetraodon nigroviridis]
1.0E-30 [33..132] [42..141]

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Predicted Domain #1
Region A:
Residues: [1-133]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKHVLAASF SMLSLLVIMG DTDSKTDSSF IMDSDPRRCM RHHYVDSISH PLYKCSSKMV  60
   61 LLARCEGHCS QASRSEPLVS FSTVLKQPFR SSCHCCRPQT SKLKALRLRC SGGMRLTATY 120
  121 RYILSCHCEE CNS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.39
Match: 1agqA
Description: Glial cell-derived neurotrophic factor, GDNF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 3.82869520790782 bayes_pls_golite062009
growth factor activity 3.62221742459173 bayes_pls_golite062009
cytokine activity 3.17846996740251 bayes_pls_golite062009
binding 3.15354794888407 bayes_pls_golite062009
protein binding 2.1792666055068 bayes_pls_golite062009
glycosaminoglycan binding 1.75705779600551 bayes_pls_golite062009
cell surface binding 1.64295809813608 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 1.60164719227409 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 1.54571273907369 bayes_pls_golite062009
heparin binding 1.49178462532916 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.24923143969832 bayes_pls_golite062009
receptor serine/threonine kinase binding 1.23697909456831 bayes_pls_golite062009
transforming growth factor beta receptor binding 1.11404326825305 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 1.11404326825305 bayes_pls_golite062009
polysaccharide binding 1.08192174862697 bayes_pls_golite062009
pattern binding 0.887560257049781 bayes_pls_golite062009
growth factor binding 0.678268907445851 bayes_pls_golite062009
protein dimerization activity 0.599417707067598 bayes_pls_golite062009
hormone activity 0.573787538297963 bayes_pls_golite062009
transcription regulator activity 0.543884186019388 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 0.506668686205984 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 0.49671267965057 bayes_pls_golite062009
protein heterodimerization activity 0.121354612226311 bayes_pls_golite062009
protein homodimerization activity 0.111053773778833 bayes_pls_golite062009
identical protein binding 0.0150102964498082 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle