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View Structure Prediction Details

Protein: gi|27436948
Organism: Homo sapiens
Length: 634 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|27436948.

Description E-value Query
Range
Subject
Range
gi|114560153 - gi|114560153|ref|XP_513875.2| PREDICTED: lamin A/C [Pan troglodytes]
294.0 [0..1] [634..437]
gi|109017515 - gi|109017515|ref|XP_001113604.1| PREDICTED: lamin A/C [Macaca mulatta]
217.0 [0..18] [634..81]
gi|73960924 - gi|73960924|ref|XP_851808.1| PREDICTED: similar to lamin A/C isoform 3 isoform 3 [Canis familiaris]
211.0 [0..1] [634..1]
LMNA - lamin A/C
gi|190691485, gi... - gi|190691485|gb|ACE87517.1| lamin A/C protein [synthetic construct], gi|190690113|gb|ACE86831.1| lam...
209.0 [0..1] [634..1]
LMNA_PIG - Prelamin-A/C OS=Sus scrofa GN=LMNA PE=3 SV=1
205.0 [0..1] [634..1]
LMNA_RAT - Prelamin-A/C OS=Rattus norvegicus GN=Lmna PE=1 SV=1
196.0 [0..1] [634..1]

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Predicted Domain #1
Region A:
Residues: [1-86]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR  60
   61 LRITESEEVV SREVSGIKAA YEAELG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [87-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DARKTLDSVA KERARLQLEL SKVREEFKEL KARNTKKEGD LIAAQARLKD LEALLNSKEA  60
   61 ALSTALSEKR TLEGELHDLR GQVAKLEAAL GEAKKQLQDE MLRRVDAENR LQTMKEELDF 120
  121 QKNIYSEELR ETKRRHETRL VEIDNGKQRE FESRLADALQ ELRAQHEDQV EQYKKELEKT 180
  181 YSAKLDNARQ SAERNSNLVG AAHEELQQSR IRIDSLSAQL S

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.08
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #3
Region A:
Residues: [308-389]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLQKQLAAKE AKLRDLEDSL ARERDTSRRL LAEKEREMAE MRARMQQQLD EYQELLDIKL  60
   61 ALDMEIHAYR KLLEGEEERL RL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.09691
Match: 1x8yA
Description: Human lamin coil 2B
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [390-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSPTSQRSR GRASSHSSQT QGGGSVTKKR KLESTESRSS FSQHARTSGR VAVEEVDEEG  60
   61 KFVRLRNKSN EDQS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.49
Match: 1ufgA
Description: Solution structure of immunoglobulin like domain of mouse nuclear lamin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [464-541]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNWQIKRQN GDDPLLTYRF PPKFTLKAGQ VVTIWAAGAG ATHSPPTDLV WKAQNTWGCG  60
   61 NSLRTALINS TGEGSHCS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1ufgA
Description: Solution structure of immunoglobulin like domain of mouse nuclear lamin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [542-634]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGDPAEYNL RSRTVLCGTC GQPADKASAS GSGAQVGGPI SSGSSASSVT VTRSYRSVGG  60
   61 SGGGSFGDNL VTRSYLLGNS SPRTQSPQNC SIM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle