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View Structure Prediction Details

Protein: gi|27436948
Organism: Homo sapiens
Length: 634 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|27436948.

Description E-value Query
Range
Subject
Range
gi|114560153 - gi|114560153|ref|XP_513875.2| PREDICTED: lamin A/C [Pan troglodytes]
294.0 [0..1] [634..437]
gi|109017515 - gi|109017515|ref|XP_001113604.1| PREDICTED: lamin A/C [Macaca mulatta]
217.0 [0..18] [634..81]
gi|73960924 - gi|73960924|ref|XP_851808.1| PREDICTED: similar to lamin A/C isoform 3 isoform 3 [Canis familiaris]
211.0 [0..1] [634..1]
LMNA - lamin A/C
gi|190691485, gi... - gi|190691485|gb|ACE87517.1| lamin A/C protein [synthetic construct], gi|190690113|gb|ACE86831.1| lam...
209.0 [0..1] [634..1]
LMNA_PIG - Prelamin-A/C OS=Sus scrofa GN=LMNA PE=3 SV=1
205.0 [0..1] [634..1]
LMNA_RAT - Prelamin-A/C OS=Rattus norvegicus GN=Lmna PE=1 SV=1
196.0 [0..1] [634..1]

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Predicted Domain #1
Region A:
Residues: [1-86]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR  60
   61 LRITESEEVV SREVSGIKAA YEAELG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [87-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DARKTLDSVA KERARLQLEL SKVREEFKEL KARNTKKEGD LIAAQARLKD LEALLNSKEA  60
   61 ALSTALSEKR TLEGELHDLR GQVAKLEAAL GEAKKQLQDE MLRRVDAENR LQTMKEELDF 120
  121 QKNIYSEELR ETKRRHETRL VEIDNGKQRE FESRLADALQ ELRAQHEDQV EQYKKELEKT 180
  181 YSAKLDNARQ SAERNSNLVG AAHEELQQSR IRIDSLSAQL S

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.08
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #3
Region A:
Residues: [308-389]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLQKQLAAKE AKLRDLEDSL ARERDTSRRL LAEKEREMAE MRARMQQQLD EYQELLDIKL  60
   61 ALDMEIHAYR KLLEGEEERL RL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.09691
Match: 1x8yA
Description: Human lamin coil 2B
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [390-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSPTSQRSR GRASSHSSQT QGGGSVTKKR KLESTESRSS FSQHARTSGR VAVEEVDEEG  60
   61 KFVRLRNKSN EDQS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.49
Match: 1ufgA
Description: Solution structure of immunoglobulin like domain of mouse nuclear lamin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [464-541]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNWQIKRQN GDDPLLTYRF PPKFTLKAGQ VVTIWAAGAG ATHSPPTDLV WKAQNTWGCG  60
   61 NSLRTALINS TGEGSHCS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1ufgA
Description: Solution structure of immunoglobulin like domain of mouse nuclear lamin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [542-634]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGDPAEYNL RSRTVLCGTC GQPADKASAS GSGAQVGGPI SSGSSASSVT VTRSYRSVGG  60
   61 SGGGSFGDNL VTRSYLLGNS SPRTQSPQNC SIM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.239 N/A N/A c.47.1 Thioredoxin-like
View Download 0.227 N/A N/A c.47.1 Thioredoxin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle