YRC Public Data Repository - Protein Structure Prediction

Protein:	SLC26A8
Organism:	Homo sapiens
Length:	970 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SLC26A8.

Description	E-value	Query Range	Subject Range
gi\|27902237 - gi\|27902237\|gb\|AAO26699.1\|AF403499_1 SLC26A8 anion exchanger [Mus musculus] gi\|16588684 - gi\|16588684\|gb\|AAL26868.1\|AF314959_1 anion transporter/exchanger-8 [Homo sapiens]	0.0	[1..970]	[1..970]
gi\|114607114, gi... - gi\|114607116\|ref\|XP_001172658.1\| PREDICTED: solute carrier family 26, member 8 isoform 3 [Pan troglo...	0.0	[1..970]	[1..969]
gi\|109509195, gi... - gi\|109509845\|ref\|XP_001078473.1\| PREDICTED: similar to solute carrier family 26, member 8 isoform a ...	0.0	[3..948]	[155..1118]
gi\|73972672 - gi\|73972672\|ref\|XP_532122.2\| PREDICTED: similar to solute carrier family 26, member 8 isoform a [Can...	0.0	[3..967]	[2..964]
gi\|76650052 - gi\|76650052\|ref\|XP_608983.2\| PREDICTED: similar to solute carrier family 26, member 8 isoform a [Bos...	0.0	[7..910]	[54..959]
SUT2_STYHA - High affinity sulfate transporter 2 OS=Stylosanthes hamata GN=ST2 PE=2 SV=1	0.0	[1..657]	[10..645]
gi\|13625941, gi\|... - gi\|162464404\|ref\|NP_001105050.1\| sulfate transporter ST1 [Zea mays], gi\|13625941\|gb\|AAK35215.1\|AF355...	0.0	[10..680]	[20..658]

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Predicted Domain #1

Region A:
Residues: [1-86]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQLERSAIS GFSSKSRRNS FAYDVKREVY NEETFQQEHK RKASSSGNMN INITTFRHHV  60
   61 QCRCSWHRFL RCVLTIFPFL EWMCMY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [87-521]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLKDWLLGDL LAGISVGLVQ VPQGLTLSLL ARQLIPPLNI AYAAFCSSVI YVIFGSCHQM  60
   61 SIGSFFLVSA LLINVLKVSP FNNGQLVMGS FVKNEFSAPS YLMGYNKSLS VVATTTFLTG 120
  121 IIQLIMGVLG LGFIATYLPE SAMSAYLAAV ALHIMLSQLT FIFGIMISFH AGPISFFYDI 180
  181 INYCVALPKA NSTSILVFLT VVVALRINKC IRISFNQYPI EFPMELFLII GFTVIANKIS 240
  241 MATETSQTLI DMIPYSFLLP VTPDFSLLPK IILQAFSLSL VSSFLLIFLG KKIASLHNYS 300
  301 VNSNQDLIAI GLCNVVSSFF RSCVFTGAIA RTIIQDKSGG RQQFASLVGA GVMLLLMVKM 360
  361 GHFFYTLPNA VLAGIILSNV IPYLETISNL PSLWRQDQYD CALWMMTFSS SIFLGLDIGL 420
  421 IISVVSAFFI TTVRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.69897
Match:	1fftA
Description:	Cytochrome O ubiquinol oxidase, subunit I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ion transmembrane transporter activity	6.40081133240949	bayes_pls_golite062009
cation transmembrane transporter activity	6.07151695779993	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	5.9695962563814	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	5.70388681170981	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	5.36384130014444	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	5.25497087659898	bayes_pls_golite062009
transporter activity	4.2806100513341	bayes_pls_golite062009
transmembrane transporter activity	4.19885907933483	bayes_pls_golite062009
substrate-specific transporter activity	4.09889747645813	bayes_pls_golite062009
heme-copper terminal oxidase activity	1.27735515053931	bayes_pls_golite062009
binding	1.12832931822264	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors	0.803860393147327	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	0.803860393147327	bayes_pls_golite062009
cytochrome-c oxidase activity	0.803860393147327	bayes_pls_golite062009
active transmembrane transporter activity	0.349031670056176	bayes_pls_golite062009
primary active transmembrane transporter activity	0.336122020727214	bayes_pls_golite062009
protein binding	0.235323288960659	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [522-687]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HRAKILLLGQ IPNTNIYRSI NDYREIITIP GVKIFQCCSS ITFVNVYYLK HKLLKEVDMV  60
   61 KVPLKEEEIF SLFNSSDTNL QGGKICRCFC NCDDLEPLPR ILYTERFENK LDPEASSINL 120
  121 IHCSHFESMN TSQTASEDQV PYTVSSVSQK NQGQQYEEVE EVWLPN

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.42
Match:	1auzA
Description:	SOLUTION STRUCTURE OF SPOIIAA, A PHOSPHORYLATABLE COMPONENT OF THE SYSTEM THAT REGULATES TRANSCRIPTION FACTOR SIGMA-F OF BACILLUS SUBTILIS, NMR, 24 STRUCTURES
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.14643407404573	bayes_pls_golite062009
protein binding	1.48694301635456	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [688-776]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSSRNSSPGL PDVAESQGRR SLIPYSDASL LPSVHTIILD FSMVHYVDSR GLVVLRQICN  60
   61 AFQNANILIL IAGCHSSIVR AFERNDFFD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.045757
Match:	1sboA
Description:	Solution Structure of putative anti sigma factor antagonist from Thermotoga maritima (TM1442)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.23164933258149	bayes_pls_golite062009
protein binding	1.6097880273634	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [777-970]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGITKTQLFL SVHDAVLFAL SRKVIGSSEL SIDESETVIR ETYSETDKND NSRYKMSSSF  60
   61 LGSQKNVSPG FIKIQQPVEE ESELDLELES EQEAGLGLDL DLDRELEPEM EPKAETETKT 120
  121 QTEMEPQPET EPEMEPNPKS RPRAHTFPQQ RYWPMYHPSM ASTQSQTQTR TWSVERRRHP 180
  181 MDSYSPEGNS NEDV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: