YRC Public Data Repository - Protein Structure Prediction

Protein:	QARS
Organism:	Homo sapiens
Length:	775 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for QARS.

Description	E-value	Query Range	Subject Range
gi\|62896579 - gi\|62896579\|dbj\|BAD96230.1\| glutaminyl-tRNA synthetase variant [Homo sapiens]	0.0	[1..775]	[1..775]
gi\|34932918, gi\|... - gi\|62663073\|ref\|XP_573963.1\| PREDICTED: glutaminyl-tRNA synthetase [Rattus norvegicus], gi\|56090285\|...	0.0	[1..775]	[1..775]
gi\|90076252 - gi\|90076252\|dbj\|BAE87806.1\| unnamed protein product [Macaca fascicularis] gi\|109039732 - gi\|109039732\|ref\|XP_001110256.1\| PREDICTED: glutaminyl-tRNA synthetase isoform 2 [Macaca mulatta]	0.0	[1..775]	[1..775]
gi\|67970692 - gi\|67970692\|dbj\|BAE01688.1\| unnamed protein product [Macaca fascicularis]	0.0	[1..775]	[1..775]
gi\|55741703 - ref\|NP_598555.1\| glutaminyl-tRNA synthetase [Mus musculus] gi\|55741703, gi\|... - gi\|74221103\|dbj\|BAE42057.1\| unnamed protein product [Mus musculus], gi\|55741703\|ref\|NP_598555.1\| glu...	0.0	[1..775]	[1..775]
gi\|73985557 - gi\|73985557\|ref\|XP_533833.2\| PREDICTED: similar to glutaminyl-tRNA synthetase isoform 1 [Canis famil...	0.0	[1..775]	[1..775]
gi\|114586868 - gi\|114586868\|ref\|XP_001147632.1\| PREDICTED: glutaminyl-tRNA synthetase [Pan troglodytes]	0.0	[1..775]	[1..817]

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Predicted Domain #1

Region A:
Residues: [1-164]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAALDSLSLF TSLGLSEQKA RETLKNSALS AQLREAATQA QQTLGSTIDK ATGILLYGLA  60
   61 SRLRDTRRLS FLVSYIASKK IHTEPQLSAA LEYVRSHPLD PIDTVDFERE CGVGVIVTPE 120
  121 QIEEAVEAAI NRHRPQLLVE RYHFNMGLLM GEARAVLKWA DGKM

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	44.200659
Match:	PF04558.6
Description:	No description for PF04558.6 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [165-246]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKNEVDMQVL HLLGPKLEAD LEKKFKVAKA RLEETDRRTA KDVVENGETA DQTLSLMEQL  60
   61 RGEALKFHKP GENYKTPGYV VT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10.221849
Match:	1iq0A
Description:	Arginyl-tRNA synthetase (ArgRS); Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [247-775]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHTMNLLKQH LEITGGQVRT RFPPEPNGIL HIGHAKAINF NFGYAKANNG ICFLRFDDTN  60
   61 PEKEEAKFFT AICDMVAWLG YTPYKVTYAS DYFDQLYAWA VELIRRGLAY VCHQRGEELK 120
  121 GHNTLPSPWR DRPMEESLLL FEAMRKGKFS EGEATLRMKL VMEDGKMDPV AYRVKYTPHH 180
  181 RTGDKWCIYP TYDYTHCLCD SIEHITHSLC TKEFQARRSS YFWLCNALDV YCPVQWEYGR 240
  241 LNLHYAVVSK RKILQLVATG AVRDWDDPRL FTLTALRRRG FPPEAINNFC ARVGVTVAQT 300
  301 TMEPHLLEAC VRDVLNDTAP RAMAVLESLR VIITNFPAAK SLDIQVPNFP ADETKGFHQV 360
  361 PFAPIVFIER TDFKEEPEPG FKRLAWGQPV GLRHTGYVIE LQHVVKGPSG CVESLEVTCR 420
  421 RADAGEKPKA FIHWVSQPLM CEVRLYERLF QHKNPEDPTE VPGGFLSDLN LASLHVVDAA 480
  481 LVDCSVALAK PFDKFQFERL GYFSVDPDSH QGKLVFNRTV TLKEDPGKV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	171.0
Match:	1qrtA
Description:	Gln-tRNA synthetase (GlnRS), C-terminal (anticodon-binding) domain; Glutaminyl-tRNA synthetase (GlnRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutamine-tRNA ligase activity	7.66556935228325	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	7.16276509815667	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.16276509815667	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.13957775963187	bayes_pls_golite062009
ligase activity	6.11211476973434	bayes_pls_golite062009
lysine-tRNA ligase activity	4.64665624411373	bayes_pls_golite062009
structural constituent of ribosome	4.61484562096458	bayes_pls_golite062009
structural molecule activity	4.261982318682	bayes_pls_golite062009
glutamate-tRNA ligase activity	2.63681738794687	bayes_pls_golite062009
catalytic activity	2.37674226834122	bayes_pls_golite062009
5S rRNA binding	2.25646775578129	bayes_pls_golite062009
rRNA binding	2.12571610259264	bayes_pls_golite062009
methionine-tRNA ligase activity	2.01261843164558	bayes_pls_golite062009
tyrosine-tRNA ligase activity	1.88984817882585	bayes_pls_golite062009
tryptophan-tRNA ligase activity	1.14187887833901	bayes_pls_golite062009
arginine-tRNA ligase activity	1.13743634264647	bayes_pls_golite062009
nucleotidyltransferase activity	1.06535308346284	bayes_pls_golite062009
cysteine-tRNA ligase activity	0.844943947059557	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.625793556381714	bayes_pls_golite062009
binding	0.47302762432927	bayes_pls_golite062009
nucleic acid binding	0.161799496958314	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: