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View Structure Prediction Details

Protein: OSBPL6
Organism: Homo sapiens
Length: 934 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OSBPL6.

Description E-value Query
Range
Subject
Range
gi|119887511, gi... - gi|76609393|ref|XP_884384.1| PREDICTED: similar to oxysterol-binding protein-like protein 6 isoform ...
0.0 [1..934] [1..934]
gi|109468331, gi... - gi|109470088|ref|XP_001062227.1| PREDICTED: similar to Oxysterol-binding protein-related protein 6 (...
0.0 [1..934] [1..928]
gi|74004722 - gi|74004722|ref|XP_850789.1| PREDICTED: similar to oxysterol-binding protein-like protein 6 isoform ...
0.0 [1..934] [1..934]
gi|62087376 - gi|62087376|dbj|BAD92135.1| oxysterol-binding protein-like protein 6 isoform a variant [Homo sapiens...
0.0 [1..934] [8..966]
OSBL6_MOUSE - Oxysterol-binding protein-related protein 6 OS=Mus musculus GN=Osbpl6 PE=1 SV=1
0.0 [1..934] [1..959]

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Predicted Domain #1
Region A:
Residues: [1-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDEKGISP AHKTSTPTHR SASSSTSSQR DSRQSIHILE RTASSSTEPS VSRQLLEPEP  60
   61 VPLSKEADSW EIIEGLKIGQ TNVQKPDKHE GFMLKKRKWP LKGWHKRFFV LDNGMLKYSK 120
  121 APLDIQKGKV HGSIDVGLSV MSIKKKARRI DLDTEEHIYH LKVKSQDWFD AWVSKLRHHR 180
  181 LYRQNEIVRS PRDASFHIFP STSTAESSPA 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.39794
Match: 1u5eA
Description: Crystal Structure of a N-terminal Fragment of SKAP-Hom Containing Both the Helical Dimerization Domain and the PH Domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.42470476396787 bayes_pls_golite062009
protein binding 2.1446140694885 bayes_pls_golite062009
receptor binding 0.3173431866346 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [211-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANVSVMDGKM QPNSFPWQSP LPCSNSLPAT CTTGQSKVAA WLQDSEEMDR CAEDLAHCQS  60
   61 NLVELSKLLQ NLEILQRTQS APNFTDMQAN CVDISKKDKR VTRRWRTKSV SKDTKIQLQV 120
  121 PFSATMSPVR LHSSNPNLCA DIEFQTPPSH LTDPLESSTD YTKLQEEFCL IAQKVHSLLK 180
  181 SAFNSIAIEK EKLKQMVSEQ DHSKG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [416-557]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSTQMARLRQ SLSQALNQNA ELRSRLNRIH SESIICDQVV SVNIIPSPDE AGEQIHVSLP  60
   61 LSQQVANESR LSMSESVSEF FDAQEVLLSA SSSENEASDD ESYISDVSDN ISEDNTSVAD 120
  121 NISRQILNGE LTGGAFRNGR RA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [558-934]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CLPAPCPDTS NINLWNILRN NIGKDLSKVS MPVELNEPLN TLQHLCEEME YSELLDKASE  60
   61 TDDPYERMVL VAAFAVSGYC STYFRAGSKP FNPVLGETYE CIREDKGFRF FSEQVSHHPP 120
  121 ISACHCESKN FVFWQDIRWK NKFWGKSMEI LPVGTLNVML PKYGDYYVWN KVTTCIHNIL 180
  181 SGRRWIEHYG EVTIRNTKSS VCICKLTFVK VNYWNSNMNE VQGVVIDQEG KAVYRLFGKW 240
  241 HEGLYCGVAP SAKCIWRPGS MPTNYELYYG FTRFAIELNE LDPVLKDLLP PTDARFRPDQ 300
  301 RFLEEGNLEA AASEKQRVEE LQRSRRRYME ENNLEHIPKF FKKVIDANQR EAWVSNDTYW 360
  361 ELRKDPGFSK VDSPVLW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.69897
Match: 1zhtA
Description: Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sterol binding 3.12877992228795 bayes_pls_golite062009
oxysterol binding 2.56824234952236 bayes_pls_golite062009
steroid binding 2.54679035876403 bayes_pls_golite062009
binding 1.67154210149282 bayes_pls_golite062009
lipid binding 1.46539100663772 bayes_pls_golite062009
0.35288515581255 bayes_pls_golite062009
phospholipid binding 0.0867097353003303 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle