| Protein: | VPS4 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 437 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS4.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [3..413] | [23..436] |
|
|
0.0 | [5..436] | [355..771] |
|
|
0.0 | [1..437] | [1..437] |
|
|
0.0 | [2..413] | [32..433] |
|
|
0.0 | [2..413] | [33..435] |
|
|
0.0 | [2..413] | [36..438] |
|
|
0.0 | [1..413] | [32..437] |
|
|
0.0 | [2..413] | [33..435] |
|
|
0.0 | [2..413] | [33..435] |
|
Region A: Residues: [1-96] |
1 11 21 31 41 51
| | | | | |
1 MSTGDFLTKG IELVQKAIDL DTATQYEEAY TAYYNGLDYL MLALKYEKNP KSKDLIRAKF 60
61 TEYLNRAEQL KKHLESEEAN AAKKSPSAGS GSNGGN
|
| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.964 | 0.295 | endoplasmic reticulum | a.118.8 | TPR-like |
| View | Download | 0.975 | 0.002 | cytoplasm | a.47.2 | t-snare proteins |
| View | Download | 0.971 | 0.002 | cytoplasm | a.7.7 | BAG domain |
| View | Download | 0.959 | 0.002 | cytoplasm | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.942 | 0.000 | ATPase activity | f.36.1 | Neurotransmitter-gated ion-channel pransmembrane pore |
| View | Download | 0.925 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.906 | N/A | N/A | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.886 | N/A | N/A | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.875 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.866 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.859 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.831 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.830 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.809 | N/A | N/A | i.11.1 | Computational models partly based on NMR data |
| View | Download | 0.808 | N/A | N/A | a.24.4 | Hemerythrin |
| View | Download | 0.805 | N/A | N/A | f.17.1 | F1F0 ATP synthase subunit C |
| View | Download | 0.803 | N/A | N/A | i.1.1 | Ribosome and ribosomal fragments |
| View | Download | 0.783 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.746 | N/A | N/A | d.8.1 | Urease, gamma-subunit |
| View | Download | 0.743 | N/A | N/A | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.737 | N/A | N/A | a.24.12 | Outer surface protein C (OspC) |
| View | Download | 0.727 | N/A | N/A | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.723 | N/A | N/A | a.23.1 | HSC20 (HSCB), C-terminal oligomerisation domain |
| View | Download | 0.707 | N/A | N/A | f.1.3 | delta-Endotoxin (insectocide), N-terminal domain |
| View | Download | 0.705 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.705 | N/A | N/A | a.24.2 | Aspartate receptor, ligand-binding domain |
| View | Download | 0.689 | N/A | N/A | a.4.1 | Homeodomain-like |
| View | Download | 0.680 | N/A | N/A | a.7.2 | Enzyme IIa from lactose specific PTS, IIa-lac |
| View | Download | 0.675 | N/A | N/A | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.651 | N/A | N/A | a.2.1 | GreA transcript cleavage protein, N-terminal domain |
| View | Download | 0.651 | N/A | N/A | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.646 | N/A | N/A | a.2.8 | Eukaryotic DNA topoisomerase I, dispensable insert domain |
| View | Download | 0.633 | N/A | N/A | a.7.8 | GAT domain |
| View | Download | 0.628 | N/A | N/A | a.4.9 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
| View | Download | 0.617 | N/A | N/A | a.7.1 | Spectrin repeat |
| View | Download | 0.603 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.599 | N/A | N/A | a.121.1 | Tetracyclin repressor-like, C-terminal domain |
| View | Download | 0.582 | N/A | N/A | d.58.26 | GHMP Kinase, C-terminal domain |
| View | Download | 0.575 | N/A | N/A | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.567 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.556 | N/A | N/A | a.133.1 | Phospholipase A2, PLA2 |
| View | Download | 0.544 | N/A | N/A | f.34.1 | Mechanosensitive channel protein MscS (YggB), transmembrane region |
| View | Download | 0.542 | N/A | N/A | a.46.1 | Methionine synthase domain |
| View | Download | 0.521 | N/A | N/A | a.2.7 | tRNA-binding arm |
| View | Download | 0.512 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.499 | N/A | N/A | a.7.7 | BAG domain |
| View | Download | 0.497 | N/A | N/A | a.2.3 | Chaperone J-domain |
| View | Download | 0.479 | N/A | N/A | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.467 | N/A | N/A | d.91.1 | N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 |
| View | Download | 0.457 | N/A | N/A | a.118.1 | ARM repeat |
| View | Download | 0.453 | N/A | N/A | a.8.3 | Families 57/38 glycoside transferase middle domain |
| View | Download | 0.443 | N/A | N/A | a.121.1 | Tetracyclin repressor-like, C-terminal domain |
| View | Download | 0.438 | N/A | N/A | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.435 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.431 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.427 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.427 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.425 | N/A | N/A | a.37.1 | A DNA-binding domain in eukaryotic transcription factors |
| View | Download | 0.408 | N/A | N/A | a.2.5 | Prefoldin |
| View | Download | 0.402 | N/A | N/A | f.13.1 | Family A G protein-coupled receptor-like |
| View | Download | 0.401 | N/A | N/A | a.47.2 | t-snare proteins |
| View | Download | 0.397 | N/A | N/A | a.17.1 | p8-MTCP1 |
| View | Download | 0.395 | N/A | N/A | a.2.7 | tRNA-binding arm |
| View | Download | 0.385 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.381 | N/A | N/A | a.69.2 | Ypt/Rab-GAP domain of gyp1p |
| View | Download | 0.379 | N/A | N/A | a.181.1 | Antibiotic binding domain of TipA-like multidrug resistance regulators |
| View | Download | 0.374 | N/A | N/A | b.91.1 | E2 regulatory, transactivation domain |
| View | Download | 0.371 | N/A | N/A | d.104.1 | Class II aaRS and biotin synthetases |
| View | Download | 0.363 | N/A | N/A | a.2.7 | tRNA-binding arm |
| View | Download | 0.356 | N/A | N/A | a.7.1 | Spectrin repeat |
| View | Download | 0.353 | N/A | N/A | a.64.1 | Saposin |
| View | Download | 0.348 | N/A | N/A | a.24.1 | Apolipoprotein |
| View | Download | 0.342 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.342 | N/A | N/A | a.7.5 | Tubulin chaperone cofactor A |
| View | Download | 0.339 | N/A | N/A | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.338 | N/A | N/A | a.2.3 | Chaperone J-domain |
| View | Download | 0.336 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.321 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.319 | N/A | N/A | a.118.16 | Testis/brain RNA-binding protein (TB-RBP) |
| View | Download | 0.307 | N/A | N/A | a.29.2 | Bromodomain |
| View | Download | 0.303 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.302 | N/A | N/A | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.299 | N/A | N/A | a.22.1 | Histone-fold |
| View | Download | 0.297 | N/A | N/A | a.60.6 | DNA polymerase beta, N-terminal domain-like |
| View | Download | 0.291 | N/A | N/A | a.51.1 | Cytochrome c oxidase subunit h |
| View | Download | 0.290 | N/A | N/A | a.151.1 | Glutamyl tRNA-reductase dimerization domain |
| View | Download | 0.286 | N/A | N/A | a.62.1 | Hepatitis B viral capsid (hbcag) |
| View | Download | 0.284 | N/A | N/A | a.2.5 | Prefoldin |
| View | Download | 0.284 | N/A | N/A | d.87.2 | CO dehydrogenase flavoprotein C-terminal domain-like |
| View | Download | 0.283 | N/A | N/A | d.110.4 | SNARE-like |
| View | Download | 0.282 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.282 | N/A | N/A | a.25.1 | Ferritin-like |
| View | Download | 0.282 | N/A | N/A | a.133.1 | Phospholipase A2, PLA2 |
| View | Download | 0.280 | N/A | N/A | d.150.1 | 4'-phosphopantetheinyl transferase |
| View | Download | 0.279 | N/A | N/A | d.81.1 | Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain |
| View | Download | 0.277 | N/A | N/A | a.24.14 | FAT domain of focal adhesion kinase |
| View | Download | 0.276 | N/A | N/A | a.7.1 | Spectrin repeat |
| View | Download | 0.270 | N/A | N/A | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.266 | N/A | N/A | a.30.1 | ROP protein |
| View | Download | 0.265 | N/A | N/A | a.29.5 | alpha-ketoacid dehydrogenase kinase, N-terminal domain |
| View | Download | 0.264 | N/A | N/A | d.29.1 | Ribosomal protein L31e |
| View | Download | 0.253 | N/A | N/A | a.133.1 | Phospholipase A2, PLA2 |
| View | Download | 0.252 | N/A | N/A | a.24.11 | Bacterial GAP domain |
| View | Download | 0.249 | N/A | N/A | a.2.3 | Chaperone J-domain |
| View | Download | 0.240 | N/A | N/A | a.38.1 | Helix-loop-helix DNA-binding domain |
| View | Download | 0.239 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.236 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.235 | N/A | N/A | a.2.6 | Effector domain of the protein kinase pkn/prk1 |
| View | Download | 0.234 | N/A | N/A | a.71.2 | Helical domain of Sec23/24 |
| View | Download | 0.234 | N/A | N/A | a.63.1 | Apolipophorin-III |
| View | Download | 0.233 | N/A | N/A | a.60.9 | lambda integrase-like, N-terminal domain |
| View | Download | 0.231 | N/A | N/A | a.48.1 | N-terminal domain of cbl (N-cbl) |
| View | Download | 0.227 | N/A | N/A | a.30.2 | Homodimeric domain of signal transducing histidine kinase |
| View | Download | 0.225 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.223 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.222 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.222 | N/A | N/A | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.220 | N/A | N/A | g.53.1 | TAZ domain |
| View | Download | 0.220 | N/A | N/A | f.14.1 | Voltage-gated potassium channels |
| View | Download | 0.220 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
| View | Download | 0.220 | N/A | N/A | a.64.1 | Saposin |
| View | Download | 0.218 | N/A | N/A | a.2.4 | Theta subunit of DNA polymerase III |
| View | Download | 0.214 | N/A | N/A | d.49.1 | Signal recognition particle alu RNA binding heterodimer, SRP9/14 |
| View | Download | 0.213 | N/A | N/A | a.130.1 | Chorismate mutase II |
| View | Download | 0.209 | N/A | N/A | a.4.1 | Homeodomain-like |
| View | Download | 0.208 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.207 | N/A | N/A | f.25.1 | Cytochrome c oxidase subunit III-like |
| View | Download | 0.206 | N/A | N/A | a.1.1 | Globin-like |
| View | Download | 0.206 | N/A | N/A | a.71.2 | Helical domain of Sec23/24 |
| View | Download | 0.205 | N/A | N/A | d.141.1 | Ribosomal protein L6 |
| View | Download | 0.203 | N/A | N/A | a.138.1 | Multiheme cytochromes |
| View | Download | 0.202 | N/A | N/A | a.24.10 | Histidine-containing phosphotransfer domain, HPT domain |
|
Region A: Residues: [97-298] |
1 11 21 31 41 51
| | | | | |
1 KKISQEEGED NGGEDNKKLR GALSSAILSE KPNVKWEDVA GLEGAKEALK EAVILPVKFP 60
61 HLFKGNRKPT SGILLYGPPG TGKSYLAKAV ATEANSTFFS VSSSDLVSKW MGESEKLVKQ 120
121 LFAMARENKP SIIFIDEVDA LTGTRGEGES EASRRIKTEL LVQMNGVGND SQGVLVLGAT 180
181 NIPWQLDSAI RRRFERRIYI PL
|
| Detection Method: | |
| Confidence: | 480.0103 |
| Match: | 1e32A_ |
| Description: | Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [299-373] |
1 11 21 31 41 51
| | | | | |
1 PDLAARTTMF EINVGDTPCV LTKEDYRTLG AMTEGYSGSD IAVVVKDALM QPIRKIQSAT 60
61 HFKDVSTEDD ETRKL
|
| Detection Method: | |
| Confidence: | 480.0103 |
| Match: | 1e32A_ |
| Description: | Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [374-437] |
1 11 21 31 41 51
| | | | | |
1 TPCSPGDDGA IEMSWTDIEA DELKEPDLTI KDFLKAIKST RPTVNEDDLL KQEQFTRDFG 60
61 QEGN
|
| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.684 | a.4.1 | Homeodomain-like |
| View | Download | 0.426 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.442 | a.35.1 | lambda repressor-like DNA-binding domains |
| View | Download | 0.486 | a.5.2 | UBA-like |
| View | Download | 0.502 | a.5.1 | DNA helicase RuvA subunit, C-terminal domain |
| View | Download | 0.390 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.390 | a.4.1 | Homeodomain-like |
| View | Download | 0.384 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.373 | a.5.7 | 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain |
| View | Download | 0.368 | a.5.1 | DNA helicase RuvA subunit, C-terminal domain |
| View | Download | 0.357 | a.3.1 | Cytochrome c |
| View | Download | 0.356 | a.144.1 | PABC (PABP) domain |
| View | Download | 0.325 | a.112.1 | Description not found. |
| View | Download | 0.325 | a.4.1 | Homeodomain-like |
| View | Download | 0.322 | a.4.1 | Homeodomain-like |
| View | Download | 0.320 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.308 | a.5.2 | UBA-like |
| View | Download | 0.306 | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.290 | a.28.1 | ACP-like |
| View | Download | 0.287 | a.60.11 | Hypothetical protein YjbJ |
| View | Download | 0.278 | a.60.3 | C-terminal domain of RNA polymerase alpha subunit |
| View | Download | 0.278 | a.5.6 | Hypothetical protein MTH1615 |
| View | Download | 0.271 | a.4.13 | Sigma3 and sigma4 domains of RNA polymerase sigma factors |
| View | Download | 0.269 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.265 | a.164.1 | C-terminal domain of DFF45/ICAD (DFF-C domain) |
| View | Download | 0.262 | a.4.1 | Homeodomain-like |
| View | Download | 0.252 | a.118.13 | Arp2/3 complex 16 kDa subunit ARPC5 |
| View | Download | 0.250 | a.36.1 | Signal peptide-binding domain |
| View | Download | 0.249 | a.56.1 | CO dehydrogenase ISP C-domain like |
| View | Download | 0.247 | a.28.1 | ACP-like |
| View | Download | 0.240 | a.76.1 | Iron-dependent represor protein, dimerization domain |
| View | Download | 0.240 | a.4.7 | Ribosomal protein L11, C-terminal domain |
| View | Download | 0.238 | a.159.1 | Protein serine/threonine phosphatase 2C, C-terminal domain |
| View | Download | 0.227 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.227 | a.4.1 | Homeodomain-like |
| View | Download | 0.222 | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.222 | a.69.1 | C-terminal domain of alpha and beta subunits of F1 ATP synthase |
| View | Download | 0.208 | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.207 | a.28.1 | ACP-like |
| View | Download | 0.204 | d.58.36 | Sulfite reductase, domains 1 and 3 |
