YRC Public Data Repository - Protein Structure Prediction

Protein:	KRE6
Organism:	Saccharomyces cerevisiae
Length:	720 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KRE6.

Description	E-value	Query Range	Subject Range
KRE6_YEAST - Beta-glucan synthesis-associated protein KRE6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288... gi\|151942930 - gi\|151942930\|gb\|EDN61276.1\| killer toxin resistant protein [Saccharomyces cerevisiae YJM789] KRE6 - Protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; appears functional... gi\|207340234 - gi\|207340234\|gb\|EDZ68649.1\| YPR159Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190408082 - gi\|190408082\|gb\|EDV11347.1\| beta-glucan synthase [Saccharomyces cerevisiae RM11-1a]	0.0	[1..720]	[1..720]
gi\|238880979 - gi\|238880979\|gb\|EEQ44617.1\| beta-glucan synthesis-associated protein KRE6 [Candida albicans WO-1] SKN1_CANAX - Beta-glucan synthesis-associated protein SKN1 OS=Candida albicans GN=SKN1 PE=2 SV=1	0.0	[16..709]	[27..736]
YEOB_SCHPO - Uncharacterized beta-glucan synthesis-associated protein C17G6.11c OS=Schizosaccharomyces pombe (str... SPAC17G6.11c - glucosidase	0.0	[67..711]	[27..636]
gi\|34484272 - gi\|34484272\|gb\|AAQ72769.1\| beta-1,6-glucan synthetase [Pneumocystis carinii]	0.0	[217..711]	[198..675]
gi\|50404321 - gi\|50404321\|gb\|AAC25554.2\| endo-beta-1,3-glucanase precursor [Pyrococcus furiosus] gi\|50404321, gi\|... - gi\|50404321\|gb\|AAC25554.2\| endo-beta-1,3-glucanase precursor [Pyrococcus furiosus], gi\|18976448\|ref\|...	7.0E-55	[258..664]	[6..297]
gi\|4980508, gi\|1... - gi\|4980508\|gb\|AAD35118.1\|AE001690_12 laminarinase [Thermotoga maritima MSB8], gi\|15642799\|ref\|NP_227... gi\|7462867 - pir\|\|B72428 laminarinase - Thermotoga maritima (strain MSB8)	2.0E-53	[324..697]	[210..496]

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Predicted Domain #1

Region A:
Residues: [1-206]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLRNLTETH NFSSTNLDTD GTGDDHDGAP LSSSPSFGQQ NDNSTNDNAG LTNPFMGSDE  60
   61 ESNARDGESL SSSVHYQPQG SDSSLLHDNS RLDLSQNKGV SDYKGYYSRN NSRAVSTAND 120
  121 NSFLQPPHRA IASSPSLNSN LSKNDILSPP EFDRYPLVGS RVTSMTQLNH HGRSPTSSPG 180
  181 NESSASFSSN PFLGEQDFSP FGGYPA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [207-277]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSFPLMIDEK EEDDYLHNPD PEEEARLDRR RFIDDFKYMD KRSASGLAGV LLLFLAAIFI  60
   61 FIVLPALTFT G

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	14.886057
Match:	PF03935
Description:	Beta-glucan synthesis-associated protein (SKN1)

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	1.82375683349763	bayes_pls_golite062009
protein binding	0.964880666937228	bayes_pls_golite062009
nucleic acid binding	0.351620947205387	bayes_pls_golite062009
transcription regulator activity	0.21069016920331	bayes_pls_golite062009
DNA binding	0.0547031308830381	bayes_pls_golite062009
carbohydrate binding	0.0124152418993231	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [278-551]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AIDHESNTEE VTYLTQYQYP QLSAIRTSLV DPDTPDTAKT REAMDGSKWE LVFSDEFNAE  60
   61 GRTFYDGDDP YWTAPDVHYD ATKDLEWYSP DASTTVNGTL QLRMDAFKNH GLYYRSGMLQ 120
  121 SWNKVCFTQG ALEISANLPN YGRVSGLWPG LWTMGNLGRP GYLASTQGVW PYSYESCDAG 180
  181 ITPNQSSPDG ISYLPGQKLS ICTCDGEDHP NQGVGRGAPE IDVLEGETDT KIGVGIASQS 240
  241 LQIAPFDIWY MPDYDFIEVY NFTTTTMNTY AGGP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.09691
Match:	1dypA_
Description:	kappa-Carrageenase, catalytic
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [552-720]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FQQAVSAVST LNVTWYEFGE YGGYFQKYAI EYLNDDDNGY IRWFVGDTPT YTIHAKALHP  60
   61 DGNIGWRRIS KEPMSIILNL GISNNWAYID WQYIFFPVVM SIDYVRIYQP SNAISVTCDP 120
  121 SDYPTYDYIQ SHLNAFQNAN LTTWEDAGYT FPKNILTGKC TSSKFKLSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.0
Match:	1macA_
Description:	Bacillus 1-3,1-4-beta-glucanase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: