YRC Public Data Repository - Protein Structure Prediction

Protein:	ATH1
Organism:	Saccharomyces cerevisiae
Length:	1211 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ATH1.

Description	E-value	Query Range	Subject Range
ATH1 - Acid trehalase required for utilization of extracellular trehalose ATH1_YEAST - Vacuolar acid trehalase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATH1 PE=1 SV=1 gi\|151942815 - gi\|151942815\|gb\|EDN61161.1\| acid trehalase [Saccharomyces cerevisiae YJM789]	0.0	[1..1211]	[1..1211]
gi\|25516978, gi\|... - pir\|\|AG1710 maltosephosphorylase homolog lin2226 [imported] - Listeria innocua (strain Clip11262), g... gi\|16801291 - gi\|16801291\|ref\|NP_471559.1\| hypothetical protein lin2226 [Listeria innocua Clip11262]	0.0	[120..902]	[1..745]
gi\|224501080 - gi\|224501080\|ref\|ZP_03669387.1\| maltose phosphorylase [Listeria monocytogenes FSL R2-561] gi\|16411591, gi\|... - pir\|\|AI1339 maltosephosphorylase homolog lmo2121 [imported] - Listeria monocytogenes (strain EGD-e),... gi\|16804160 - gi\|16804160\|ref\|NP_465645.1\| hypothetical protein lmo2121 [Listeria monocytogenes EGD-e]	0.0	[120..902]	[1..745]
gi\|15988492, gi\|... - gi\|15988493\|pdb\|1H54\|B Chain B, Maltose Phosphorylase From Lactobacillus Brevis, gi\|15988492\|pdb\|1H5...	0.0	[122..895]	[1..743]
gi\|23003420 - gi\|23003420\|ref\|ZP_00047083.1\| COG1554: Trehalose and maltose hydrolases (possible phosphorylases) [... gi\|116094473, gi... - gi\|23003420\|ref\|ZP_00047083.1\| hypothetical protein Lgas_03001518 [Lactobacillus gasseri ATCC 33323]...	0.0	[120..907]	[1..753]
gi\|28377121, gi\|... - gi\|28377121\|ref\|NP_784013.1\| maltose phosphorylase [Lactobacillus plantarum WCFS1], gi\|28269952\|emb\|... gi\|227854191, gi... - gi\|227897567\|ref\|ZP_04015372.1\| maltose phosphorylase [Lactobacillus plantarum subsp. plantarum ATCC... gi\|254555339, gi... - gi\|254555339\|ref\|YP_003061756.1\| maltose phosphorylase [Lactobacillus plantarum JDM1], gi\|254044266\|...	0.0	[122..902]	[1..749]
gi\|27544256 - gi\|27544256\|dbj\|BAC54904.1\| maltose phosphorylase [Bacillus sp. RK-1] gi\|60729610 - gi\|60729610\|pir\|\|JC7917 maltose phosphorylase (EC 2.4.1.8) - Bacillus sp. (Strain RK-1)	0.0	[120..904]	[1..751]
TREA_EMENI - Acid trehalase OS=Emericella nidulans GN=treA PE=3 SV=1 TREA_EMENI - Acid trehalase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) G...	0.0	[119..1080]	[52..992]
gi\|15676304, gi\|... - gi\|7225612\|gb\|AAF40830.1\| maltose phosphorylase [Neisseria meningitidis MC58], gi\|15676304\|ref\|NP_27... gi\|11353787 - pir\|\|F81203 maltose phosphorylase NMB0390 [imported] - Neisseria meningitidis (strain MC58 serogroup...	0.0	[121..908]	[1..748]

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Predicted Domain #1

Region A:
Residues: [1-103]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRIRSLWFN AEASYSNLNN SPSLRNKNST GNNSRSKNYR SFSRFDLINS ILLLMMLFLL  60
   61 AIFVTALYLT KSSRLTYSHA SRAALFNPLG VISPSLGNHT LNY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [104-203]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DPEARESSKK LYELLSDFNT AYYDDENMIL GSNLFSKNTY SRQPYVANGY IGSRIPNIGF  60
   61 GYALDTLNFY TDAPGALNNG WPLRNHRFAG AFVSDFYCLQ

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [219-454]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSTVISSIPQ WTNLQFSLVN DSKWFNPQNV TLDDVTNYSQ NLSMKDGIVT TELDWLNSQI  60
   61 HVKSEIWAHR HIHPLGVVSL EISLNTDHLP SDFDSLDVNI WDILDFNTSH RTVLHSTGTD 120
  121 EKNNAVFMIV QPDNVPSSNC AIYSTCTVKY ENSTNPINSS ESFEEKDVSS NIYNVILTED 180
  181 QPKIIVHKYV GIMSTEFNKN KEQQDNTNIG LAKMIALNSK GNYEKLLSSH KRAWYD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1186.9897
Match:	1h54B_
Description:	Lactobacillus maltose phosphorylase, central domain; Lactobacillus maltose phosphorylase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
trehalase activity	6.1631598954361	bayes_pls_golite062009
alpha,alpha-trehalase activity	4.14152750025521	bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds	2.50689026793054	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	1.83258795002493	bayes_pls_golite062009
glucosidase activity	1.57801734898595	bayes_pls_golite062009
mannosidase activity	1.4241704904012	bayes_pls_golite062009
hydrolase activity	1.34245977545258	bayes_pls_golite062009
alpha-mannosidase activity	1.12854242860035	bayes_pls_golite062009
glucan 1,4-alpha-glucosidase activity	0.999235506386059	bayes_pls_golite062009
catalytic activity	0.770933849734279	bayes_pls_golite062009
racemase and epimerase activity, acting on carbohydrates and derivatives	0.68102716507433	bayes_pls_golite062009
binding	0.618918442496488	bayes_pls_golite062009
racemase and epimerase activity	0.473636146090495	bayes_pls_golite062009
isomerase activity	0.106573908779409	bayes_pls_golite062009
protein binding	0.0588743714903849	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [204-218]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKLNSTNFPE LDDVG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [455-918]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYNDAFIEIP SDSLLEMTAR SSLFHLLANT RDYNVSSDRG LPVGVSGLSS DSYGGMVFWD  60
   61 ADIWMEPALL PFFPNVAQNM NNYRNATHSQ AKLNAEKYGY PGAIYPWTSG KYANCTSTGP 120
  121 CVDYEYHINV DVAMASFSIY LNGHEGIDDE YLRYTTWPII KNAAQFFTAY VKYNSSLGLY 180
  181 ETYNLTDPDE FANHINNGAF TNAGIKTLLK WATDIGNHLG EVVDPKWSEI SKDIYIPRSS 240
  241 SNITLEYSGM NSSVEIKQAD VTLMVYPLGY INDESILNNA IKDLYYYSER QSASGPAMTY 300
  301 PVFVAAAAGL LNHGSSSQSY LYKSVLPYLR APFAQFSEQS DDNFLTNGLT QPAFPFLTAN 360
  361 GGFLQSILFG LTGIRYSYEV DPDTKKINRL LRFNPIELPL LPGGIAIRNF KYMNQVLDII 420
  421 IDDHNGTIVH KSGDVPIHIK IPNRSLIHDQ DINFYNGSEN ERKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1186.9897
Match:	1h54B_
Description:	Lactobacillus maltose phosphorylase, central domain; Lactobacillus maltose phosphorylase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [919-1211]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLERRDVDRV GDPMRMDRYG TYYLLKPKQE LTVQLFKPGL NARNNIAENK QITNLTAGVP  60
   61 GDVAFSALDG NNYTHWQPLD KIHRAKLLID LGEYNEKEIT KGMILWGQRP AKNISISILP 120
  121 HSEKVENLFA NVTEIMQNSG NDQLLNETIG QLLDNAGIPV ENVIDFDGIE QEDDESLDDV 180
  181 QALLHWKKED LAKLIEQIPR LNFLKRKFVK ILDNVPVSPS EPYYEASRNQ SLIEILPSNR 240
  241 TTFTIDYDKL QVGDKGNTDW RKTRYIVVAV QGVYDDYDDD NKGATIKEIV LND

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: