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View Structure Prediction Details

Protein: EAF3
Organism: Saccharomyces cerevisiae
Length: 401 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EAF3.

Description E-value Query
Range
Subject
Range
gi|114658395 - gi|114658395|ref|XP_001152287.1| PREDICTED: MORF-related gene 15 isoform 5 [Pan troglodytes]
MORF4L1 - mortality factor 4 like 1
ENSCJAT00000004355 - null
0.0 [3..390] [6..361]
MO4L1_MOUSE - Mortality factor 4-like protein 1 OS=Mus musculus GN=Morf4l1 PE=1 SV=2
0.0 [3..390] [6..361]
EAF3_YEAST - Chromatin modification-related protein EAF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
gi|151942812 - gi|151942812|gb|EDN61158.1| NuA4 histone acetyltransferase subunit [Saccharomyces cerevisiae YJM789]
EAF3 - Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to...
0.0 [1..401] [1..401]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [3..390] [6..322]

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Predicted Domain #1
Region A:
Residues: [1-94]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDLEQEFAL GGRCLAFHGP LMYEAKILKI WDPSSKMYTS IPNDKPGGSS QATKEIKPQK  60
   61 LGEDESIPEE IINGKCFFIH YQGWKSSWDE WVGY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
chromatin binding 3.84065302930105 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
methylated histone residue binding 3.42338304360938 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
histone binding 2.00388175060339 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
DNA-dependent ATPase activity 0.998957812785999 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
DNA helicase activity 0.726970683178132 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.494788451379878 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [95-401]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRIRAYNEEN IAMKKRLANE AKEAKKSLLE QQKKKKLSTS LGGPSNGGKR KGDSRSNASI  60
   61 SKSTSQSFLT SSVSGRKSGR SSANSLHPGS SLRSSSDQNG NDDRRRSSSL SPNMLHHIAG 120
  121 YPTPKISLQI PIKLKSVLVD DWEYVTKDKK ICRLPADVTV EMVLNKYEHE VSQELESPGS 180
  181 QSQLSEYCAG LKLYFDKCLG NMLLYRLERL QYDELLKKSS KDQKPLVPIR IYGAIHLLRL 240
  241 ISVLPELISS TTMDLQSCQL LIKQTEDFLV WLLMHVDEYF NDKDPNRSDD ALYVNTSSQY 300
  301 EGVALGM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle