YRC Public Data Repository - Protein Structure Prediction

Protein:	CET1
Organism:	Saccharomyces cerevisiae
Length:	549 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CET1.

Description	E-value	Query Range	Subject Range
CET1_YEAST - mRNA-capping enzyme subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CET1 PE... CET1 - Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is...	0.0	[1..549]	[1..549]
CET1_CANAL - mRNA-capping enzyme subunit beta OS=Candida albicans GN=CET1 PE=3 SV=2 CET1_CANAL - mRNA-capping enzyme subunit beta OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CET1 PE=3 SV...	0.0	[140..537]	[91..519]
pct1 - RNA 5'-triphosphatase CET1_SCHPO - mRNA-capping enzyme subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pct1 PE=1...	7.0E-80	[267..535]	[43..303]
gi\|28919346, gi\|... - gi\|32423407\|ref\|XP_332141.1\| hypothetical protein [Neurospora crassa], gi\|28919346\|gb\|EAA28799.1\| pr... gi\|85089627 - gi\|85089627\|ref\|XP_958035.1\| hypothetical protein NCU09449 [Neurospora crassa OR74A]	4.0E-78	[269..532]	[758..1056]
gi\|19074234, gi\|... - gi\|19074234\|ref\|NP_584840.1\| hypothetical protein ECU04_1550 [Encephalitozoon cuniculi GB-M1], gi\|19... gi\|19074234 - ref\|NP_584840.1\| hypothetical protein [Encephalitozoon cuniculi]	2.0E-47	[297..509]	[16..208]

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Predicted Domain #1

Region A:
Residues: [1-219]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYTDNPPQT KRALSLDDLV NHDENEKVKL QKLSEAANGS RPFAENLESD INQTETGQAA  60
   61 PIDNYKESTG HGSHSQKPKS RKSSNDDEET DTDDEMGASG EINFDSEMDF DYDKQHRNLL 120
  121 SNGSPPMNDG SDANAKLEKP SDDSIHQNSK SDEEQRIPKQ GNEGNIASNY ITQVPLQKQK 180
  181 QTEKKIAGNA VGSVVKKEEE ANAAVDNIFE EKATLQSKK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [220-549]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNIKRDLEVL NEISASSKPS KYRNVPIWAQ KWKPTIKALQ SINVKDLKID PSFLNIIPDD  60
   61 DLTKSVQDWV YATIYSIAPE LRSFIELEMK FGVIIDAKGP DRVNPPVSSQ CVFTELDAHL 120
  121 TPNIDASLFK ELSKYIRGIS EVTENTGKFS IIESQTRDSV YRVGLSTQRP RFLRMSTDIK 180
  181 TGRVGQFIEK RHVAQLLLYS PKDSYDVKIS LNLELPVPDN DPPEKYKSQS PISERTKDRV 240
  241 SYIHNDSCTR IDITKVENHN QNSKSRQSET THEVELEINT PALLNAFDNI TNDSKEYASL 300
  301 IRTFLNNGTI IRRKLSSLSY EIFEGSKKVM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1834.0
Match:	1d8hA_
Description:	mRNA triphosphatase CET1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
polynucleotide 5'-phosphatase activity	11.2864202061301	bayes_pls_golite062009
nucleotide phosphatase activity	5.10806075014632	bayes_pls_golite062009
binding	1.32114964285132	bayes_pls_golite062009
catalytic activity	1.17990683373825	bayes_pls_golite062009
hydrolase activity	0.487109994827608	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: