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View Structure Prediction Details

Protein: ERR1, ERR2
Organism: Saccharomyces cerevisiae
Length: 437 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERR1, ERR2.

Description E-value Query
Range		 Subject
Range
ENOA_CHICK - Alpha-enolase OS=Gallus gallus GN=ENO1 PE=2 SV=2
 0.0 [1..434] [1..431]
ENOA_ANAPL - Alpha-enolase OS=Anas platyrhynchos GN=ENO1 PE=2 SV=2
 0.0 [1..434] [1..431]
gi|60824596, gi|... - gi|61373094|gb|AAX43977.1| enolase 1 [synthetic construct], gi|61364993|gb|AAX42637.1| enolase 1 [sy...
 0.0 [1..434] [1..431]
gi|114552694 - gi|114552694|ref|XP_514354.2| PREDICTED: enolase 1 [Pan troglodytes]
ENO1 - enolase 1, (alpha)
gi|123995887, gi... - gi|61354812|gb|AAX41062.1| enolase 1 [synthetic construct], gi|60812591|gb|AAX36218.1| enolase 1 [sy...
 0.0 [1..434] [1..431]
gi|12963491, gi|... - gi|12963491|ref|NP_075608.1| enolase 1, alpha non-neuron [Mus musculus], pir||S10246 phosphopyruvate...
gi|55491 - gi|55491|emb|CAA36605.1| unnamed protein product [Mus sp.]
 0.0 [1..434] [1..431]
gi|6978809, gi|5... - pir||A23126 phosphopyruvate hydratase (EC 4.2.1.11) alpha - rat, gi|6978809|ref|NP_036686.1| enolase...
 0.0 [1..434] [1..431]
ENOA_ALLMI - Alpha-enolase OS=Alligator mississippiensis PE=2 SV=3
 0.0 [1..434] [1..431]
gi|21325980, gi|... - gi|21325986|gb|AAM47554.1|AF428108_1 alpha-enolase [Crocodylus palustris], gi|21325984|gb|AAM47553.1...
 0.0 [1..434] [1..431]

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Predicted Domain #1
Region A:
Residues: [1-127] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSITKVHART VYDSRGNPTV EVEITTENGL FRAIVPSGAS TGIHEAVELR DGNKSEWMGK  60
   61 GVTKAVSNVN SIIGPALIKS ELCVTNQKGI DELMISLDGT SNKSRLGANA ILGVSLCVAR 120
  121 AAAAQKG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2800.0
Match: 1els__
Description: Enolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphopyruvate hydratase activity 10.7545435133049 bayes_pls_golite062009
transcription regulator activity 2.33007926350873 bayes_pls_golite062009
nucleic acid binding 2.15117039251634 bayes_pls_golite062009
DNA binding 1.97129250063131 bayes_pls_golite062009
binding 1.95079397144714 bayes_pls_golite062009
intramolecular lyase activity 1.72552670956901 bayes_pls_golite062009
transcription repressor activity 1.36446664329679 bayes_pls_golite062009
transcription factor activity 1.24065454553451 bayes_pls_golite062009
lyase activity 0.953241510600178 bayes_pls_golite062009
carbon-oxygen lyase activity 0.908937887773213 bayes_pls_golite062009
hydro-lyase activity 0.874016693867333 bayes_pls_golite062009
catalytic activity 0.534516847146079 bayes_pls_golite062009
protein binding 0.476896736636797 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [128-437] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ITLYKYIAEL ADARQDPFVI PVPFFNVLNG GAHAGGSLAM QEFKIAPVGA QSFAEAMRMG  60
   61 SEVYHHLKIL AKEQYGPSAG NVGDEGGVAP DIDTAEDALD MIVEAINICG YEGRVKVGID 120
  121 SAPSVFYKDG KYDLNFKEPN SDPSHWLSPA QLAEYYHSLL KKYPIISLED PYAEDDWSSW 180
  181 SAFLKTVNVQ IIADDLTCTN KTRIARAIEE KCANTLLLKL NQIGTLTESI EAANQAFDAG 240
  241 WGVMISHRSG ETEDPFIADL VVGLRCGQIK SGALSRSERL AKYNELLRIE EELGDDCIYA 300
  301 GHRFHDGNKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2800.0
Match: 1els__
Description: Enolase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle