YRC Public Data Repository - Protein Structure Prediction

Protein:	PDE2
Organism:	Saccharomyces cerevisiae
Length:	526 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDE2.

Description	E-value	Query Range	Subject Range
gi\|172106 - gi\|172106\|gb\|AAA34846.1\| cAMP phosphodiesterase	569.0	[0..1]	[526..1]
gi\|2706887 - gi\|2706887\|gb\|AAB96875.1\| PDE4C-791 [Homo sapiens]	494.0	[0..98]	[526..297]
gi\|73986145 - gi\|73986145\|ref\|XP_852383.1\| PREDICTED: similar to cAMP-specific 3,5-cyclic phosphodiesterase 4C (DP...	494.0	[0..98]	[526..396]
gi\|76621077 - gi\|76621077\|ref\|XP_602953.2\| PREDICTED: similar to cAMP-specific 3,5-cyclic phosphodiesterase 4C (DP...	484.0	[0..98]	[526..321]
gi\|109503974, gi... - gi\|109503974\|ref\|XP_001070301.1\| PREDICTED: similar to cAMP-specific 3,5-cyclic phosphodiesterase 4C...	483.0	[0..98]	[522..213]
PDE4C_MOUSE - cAMP-specific 3',5'-cyclic phosphodiesterase 4C OS=Mus musculus GN=Pde4c PE=1 SV=1	483.0	[0..98]	[525..220]

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Predicted Domain #1

Region A:
Residues: [1-133]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLFLIGIH EIEKSQTIVQ NEHYFDRVIE LQDLDSLMVA LYKDRVSPFP NVHNFETGVS  60
   61 IVLYDPSKFQ LSVRQLDVLF KRFFPSFNIS AIDHTREENL QRLECVEREN SICRNRITRI 120
  121 NHWMYHHHDD TPD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [134-370]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GINKNSYGTV NGNSVPTQAC EANIYTLLLH LNDSKAQHLR KASVPRLIRN IEFMSFLSDP  60
   61 IEKISQEGSH YWNILSTWDF CALSLSTQEL IWCGFTLIKK LSKDAKVLIA DNKLLLLLFT 120
  121 LESSYHQVNK FHNFRHAIDV MQATWRLCTY LLKDNPVQTL LLCMAAIGHD VGHPGTNNQL 180
  181 LCNCESEVAQ NFKNVSILEN FHRELFQQLL SEHWPQLLSI SKKKFDFISE AILATDM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	236.0103
Match:	1oynA
Description:	Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [371-526]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALHSQYEDRL MHENPMKQIT LISLIIKAAD ISNVTRTLSI SARWAYLITL EFNDCALLET  60
   61 FHKAHRPEQD CFGDSYKNVD SPKEDLESIQ NILVNVTDPD DIIKDHPHIP NGQIFFINTF 120
  121 AEVFFNALSQ KFSGLKFLSD NVKINKEYWM KHKKPQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	236.0103
Match:	1oynA
Description:	Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits