YRC Public Data Repository - Protein Structure Prediction

Protein:	HAP5
Organism:	Saccharomyces cerevisiae
Length:	242 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HAP5.

Description	E-value	Query Range	Subject Range
HAP5 - Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional... gi\|190407651 - gi\|190407651\|gb\|EDV10918.1\| CCAAT-binding transcription factor component [Saccharomyces cerevisiae R... gi\|207340830 - gi\|207340830\|gb\|EDZ69060.1\| YOR358Wp-like protein [Saccharomyces cerevisiae AWRI1631] HAP5_YEAST - Transcriptional activator HAP5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HAP5 PE=1... gi\|151945435 - gi\|151945435\|gb\|EDN63678.1\| CCAAT-binding transcription factor component (along with Hap2p and Hap3p...	1.0E-54	[1..242]	[1..242]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	6.0E-45	[27..242]	[1..216]
gi\|2583171 - gi\|2583171\|gb\|AAC15237.1\| CCAAT-binding transcription factor subunit AAB-1 [Neurospora crassa]	3.0E-36	[66..239]	[1..167]
H2A4_VOLCA - Histone H2A-IV OS=Volvox carteri PE=3 SV=1	3.0E-34	[136..235]	[1..100]
gi\|32967225 - gi\|32967225\|gb\|AAP92405.1\| HapE [Aspergillus niger]	4.0E-34	[69..239]	[1..166]
gi\|7023238, gi\|8... - gi\|8922758\|ref\|NP_060737.1\| H2A histone family, member J isoform 1 [Homo sapiens], gi\|7023238\|dbj\|BA...	7.0E-34	[138..235]	[4..101]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-33	[141..235]	[14..108]
gi\|14577940 - gi\|14577940\|gb\|AAK68863.1\| CCAAT-binding protein subunit HAP5 [Hypocrea jecorina]	1.0E-33	[66..239]	[1..167]
H2A_CHLRE - Histone H2A OS=Chlamydomonas reinhardtii GN=H2A-II PE=3 SV=1	2.0E-33	[136..235]	[1..100]

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Predicted Domain #1

Region A:
Residues: [1-142]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDRNFSPQQ GQGPQESLPE GPQPSTMIQR EEMNMPRQYS EQQQLQENEG EGENTRLPVS  60
   61 EEEFRMVQEL QAIQAGHDQA NLPPSGRGSL EGEDNGNSDG ADGEMDEDDE EYDVFRNVGQ 120
  121 GLVGHYKEIM IRYWQELINE IE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.256	0.122	intracellular	a.24.14	FAT domain of focal adhesion kinase
View	Download	0.262	0.083	intracellular	a.73.1	Retrovirus capsid protein, N-terminal core domain
View	Download	0.262	0.056	CCAAT-binding factor complex	a.73.1	Retrovirus capsid protein, N-terminal core domain
View	Download	0.256	0.018	CCAAT-binding factor complex	a.24.14	FAT domain of focal adhesion kinase

Predicted Domain #2

Region A:
Residues: [143-242]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STNEPGSEHQ DDFKSHSLPF ARIRKVMKTD EDVKMISAEA PIIFAKACEI FITELTMRAW  60
   61 CVAERNKRRT LQKADIAEAL QKSDMFDFLI DVVPRRPLPQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	311.67837
Match:	1n1jB_
Description:	Nuclear transcription factor Y subunit gamma (Nf-Yc2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA binding	4.24625687315724	bayes_pls_golite062009
transcription regulator activity	4.08606081850613	bayes_pls_golite062009
nucleic acid binding	3.93473976418251	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	3.89663803383145	bayes_pls_golite062009
binding	3.84636641231951	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.38228606466152	bayes_pls_golite062009
transcription factor activity	2.31114764804139	bayes_pls_golite062009
transcription activator activity	1.25487495162413	bayes_pls_golite062009
transcription factor binding	1.15204005455906	bayes_pls_golite062009
transcription coactivator activity	1.1297723528047	bayes_pls_golite062009
transcription cofactor activity	1.01502031330902	bayes_pls_golite062009
protein binding	0.978906971260821	bayes_pls_golite062009
transcription repressor activity	0.72554769377984	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: