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View Structure Prediction Details

Protein: SNU66
Organism: Saccharomyces cerevisiae
Length: 587 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SNU66.

Description E-value Query
Range
Subject
Range
SNU66 - Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required...
SNU66_YEAST - 66 kDa U4/U6.U5 small nuclear ribonucleoprotein component OS=Saccharomyces cerevisiae (strain ATCC 2...
0.0 [1..587] [1..587]
gi|11066881 - gi|11066881|gb|AAG28744.1| squamous cell carcinoma antigen recognised by cytotoxic T lymphocytes [Ta...
0.0 [6..571] [99..724]
gi|11066917 - gi|11066917|gb|AAG28762.1|AF299060_1 squamous-cell carcinoma T-cell-recognized antigen [Tetraodon ni...
0.0 [6..571] [100..726]
gi|2342526 - gi|2342526|emb|CAA74694.1| IgE autoantigen [Homo sapiens]
0.0 [6..571] [75..709]
SNUT1_MOUSE - U4/U6.U5 tri-snRNP-associated protein 1 OS=Mus musculus GN=Sart1 PE=1 SV=1
0.0 [6..571] [117..758]
gi|4126471, gi|1... - gi|4126471|dbj|BAA36584.1| rSALT-1(806) [Rattus norvegicus], gi|13928810|ref|NP_113784.1| squamous c...
0.0 [6..571] [117..758]
CG6686-PB - This gene is referred to in FlyBase by the symbol Dmel\CG6686 (CG6686, FBgn0032388). It is a protein...
gi|220951818 - gi|220951818|gb|ACL88452.1| CG6686-PB [synthetic construct]
0.0 [5..571] [271..911]

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Predicted Domain #1
Region A:
Residues: [1-411]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKTENLSIE ETNEIREKLG MKPIPVFQEK NTDHKESLSI EETNELRASL GLKLIPPQQN  60
   61 FNSSPPNVHN TSKIDELREK ITKFQKKANA PLRMAHLLEE TNVNDDSSWL ENMDAIPSSH 120
  121 ESKRSSTLPR KGATKEDENI DLHNVQVSYN IEALSPKKDT ILTLKESSIF DDTDSTEVLE 180
  181 NVKAAEENAD REKLRLRQMN KDRRQKKKIL NVSSLDIEEE EEGEKHSITT THLIIGAEQG 240
  241 VMKAPNTISA KPPTGKVKVN FDSANNMSDE DGGDFKPLKI KKRKIKDPRS TKARKSKITD 300
  301 KMEIVKLVDE DESLSWMEEE QPVTIINPRT SSNNELKGPE DLAREIEKAR DEEKRRTESI 360
  361 LKMREISNSI VVDEKVTFLN TLDTSLSERS ATENKVKVHG EGEKNIGDVT N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.09691
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [412-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHTKEGSGNN TLTEAVNNEP NYEGDAENAP NFFSGLASTL GYLRKKSVFT TGDVDLKPGK  60
   61 DVNNSESLRR DVRNKEHTGT GTYTKDKLHG LEQFTSSDSS NANTHSKRQD HYDPDIKLVY 120
  121 RDEKGNRLTT KEAYKKLSQK FHGTKSNKKK RAKMKSRIEA RKNTPENGSL FEFDDN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [271-438]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGGDFKPLKI KKRKIKDPRS TKARKSKITD KMEIVKLVDE DESLSWMEEE QPVTIINPRT  60
   61 SSNNELKGPE DLAREIEKAR DEEKRRTESI LKMREISNSI VVDEKVTFLN TLDTSLSERS 120
  121 ATENKVKVHG EGEKNIGDVT NGHTKEGSGN NTLTEAVNNE PNYEGDAE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [439-587]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAPNFFSGLA STLGYLRKKS VFTTGDVDLK PGKDVNNSES LRRDVRNKEH TGTGTYTKDK  60
   61 LHGLEQFTSS DSSNANTHSK RQDHYDPDIK LVYRDEKGNR LTTKEAYKKL SQKFHGTKSN 120
  121 KKKRAKMKSR IEARKNTPEN GSLFEFDDN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.96
Match: 1gh6A
Description: Large T antigen, the N-terminal J domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.976140922616 bayes_pls_golite062009
protein binding 1.24691264244807 bayes_pls_golite062009
transcription regulator activity 1.22205034569359 bayes_pls_golite062009
nucleic acid binding 0.956364358495558 bayes_pls_golite062009
DNA binding 0.894959464232481 bayes_pls_golite062009
catalytic activity 0.137993331191769 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle