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View Structure Prediction Details

Protein: DFR1
Organism: Saccharomyces cerevisiae
Length: 211 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DFR1.

Description E-value Query
Range		 Subject
Range
DYR_YEAST - Dihydrofolate reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DFR1 PE=1 SV=2
DFR1 - Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possi...
gi|190407543 - gi|190407543|gb|EDV10810.1| dihydrofolate reductase [Saccharomyces cerevisiae RM11-1a]
 3.0E-56 [1..211] [1..211]
gi|85658490, gi|... - gi|88601320|tpd|FAA00073.1| TPA: dihydrofolate reductase [Cricetulus griseus], gi|85658490|dbj|BAE78...
gi|304502 - gi|304502|gb|AAA36970.1| dihydrofolate reductase (EC 1.5.1.3)
 1.0E-52 [9..211] [5..186]
DYR_MOUSE - Dihydrofolate reductase OS=Mus musculus GN=Dhfr PE=1 SV=3
 1.0E-52 [9..211] [5..186]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-52 [9..211] [4..185]
DYR_RAT - Dihydrofolate reductase OS=Rattus norvegicus GN=Dhfr PE=2 SV=3
 2.0E-52 [9..211] [5..186]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
 5.0E-52 [9..211] [4..185]
DYR_MESAU - Dihydrofolate reductase OS=Mesocricetus auratus GN=DHFR PE=2 SV=4
gi|191046 - gi|191046|gb|AAA36971.1| dihydrofolate reductase
 8.0E-52 [9..211] [5..186]

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Predicted Domain #1
Region A:
Residues: [1-211] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGGKIPIVG IVACLQPEMG IGFRGGLPWR LPSEMKYFRQ VTSLTKDPNK KNALIMGRKT  60
   61 WESIPPKFRP LPNRMNVIIS RSFKDDFVHD KERSIVQSNS LANAIMNLES NFKEHLERIY 120
  121 VIGGGEVYSQ IFSITDHWLI TKINPLDKNA TPAMDTFLDA KKLEEVFSEQ DPAQLKEFLP 180
  181 PKVELPETDC DQRYSLEEKG YCFEFTLYNR K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 389.616428
Match: 1ai9A_
Description: Dihydrofolate reductases, eukaryotic type
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
dihydrofolic acid binding 5.17709559620199 bayes_pls_golite062009
dihydrofolate reductase activity 4.66343252900911 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor 4.14137539326183 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors 3.88025481634404 bayes_pls_golite062009
catalytic activity 1.48020895637259 bayes_pls_golite062009
oxidoreductase activity 1.39855499164233 bayes_pls_golite062009
binding 0.576814191883416 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle