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View Structure Prediction Details

Protein: PNO1
Organism: Saccharomyces cerevisiae
Length: 274 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PNO1.

Description E-value Query
Range
Subject
Range
PNO1_YEAST - Pre-rRNA-processing protein PNO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNO1 PE...
PNO1 - Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA ...
1.0E-49 [1..274] [1..274]
PNO1_MOUSE - RNA-binding protein PNO1 OS=Mus musculus GN=Pno1 PE=1 SV=1
3.0E-47 [50..274] [27..248]
PNO1 - partner of NOB1 homolog (S. cerevisiae)
1.0E-46 [32..274] [2..252]
FUBP2_CHICK - Far upstream element-binding protein 2 OS=Gallus gallus GN=KHSRP PE=1 SV=1
8.0E-46 [1..252] [200..454]
gi|19115426 - gi|19115426|ref|NP_594514.1| hypothetical protein SPAC2C4.11c [Schizosaccharomyces pombe 972h-]
rbp28 - RNA-binding protein Rbp28
4.0E-43 [1..273] [1..257]
FUBP2_RAT - Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1
8.0E-42 [1..252] [138..392]

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Predicted Domain #1
Region A:
Residues: [1-86]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAPTALKKA TVTPVSGQDG GSSRIIGINN TESIDEDDDD DVLLDDSDNN TAKEEVEGEE  60
   61 GSRKTHESKT VVVDDQGKPR FTSASK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.253 0.755 rRNA processing b.1.1 Immunoglobulin
View Download 0.304 0.078 rRNA processing b.1.2 Fibronectin type III
View Download 0.323 0.013 rRNA processing a.24.13 Domain of the SRP/SRP receptor G-proteins

Predicted Domain #2
Region A:
Residues: [87-181]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TQGNKIKFES RKIMVPPHRM TPLRNSWTKI YPPLVEHLKL QVRMNLKTKS VELRTNPKFT  60
   61 TDPGALQKGA DFIKAFTLGF DLDDSIALLR LDDLY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.39794
Match: 1j4wA_
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.07437653952404 bayes_pls_golite062009
mRNA binding 4.07599584461947 bayes_pls_golite062009
nucleic acid binding 3.68444148122352 bayes_pls_golite062009
binding 3.31174833550232 bayes_pls_golite062009
1.56143840583911 bayes_pls_golite062009
transcription regulator activity 1.43703138180882 bayes_pls_golite062009
protein binding 1.37279927568272 bayes_pls_golite062009
DNA binding 1.20852534725468 bayes_pls_golite062009
poly-pyrimidine tract binding 0.9296581376632 bayes_pls_golite062009
transcription factor activity 0.386248501195543 bayes_pls_golite062009
single-stranded RNA binding 0.3686746342524 bayes_pls_golite062009
structure-specific DNA binding 0.32222928997178 bayes_pls_golite062009
catalytic activity 0.113112541746059 bayes_pls_golite062009
single-stranded DNA binding 0.1069917291606 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [182-274]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IETFEVKDVK TLTGDHLSRA IGRIAGKDGK TKFAIENATR TRIVLADSKI HILGGFTHIR  60
   61 MARESVVSLI LGSPPGKVYG NLRTVASRLK ERY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.39794
Match: 1j4wA_
Description: Far upstream binding element, FBP, KH3 and KH4 domains
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle