YRC Public Data Repository - Protein Structure Prediction

Protein:	GCY1
Organism:	Saccharomyces cerevisiae
Length:	312 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GCY1.

Description	E-value	Query Range	Subject Range
gi\|15208400 - gi\|15208400\|dbj\|BAB63207.1\| 3(20)alpha-hydroxysteroid/dihydrodiol/indanol dehydrogenase [Macaca fusc... AK1C1_MACFU - Aldo-keto reductase family 1 member C1 homolog OS=Macaca fuscata fuscata GN=AKR1C1 PE=2 SV=1 gi\|109088079, gi... - gi\|109088083\|ref\|XP_001103887.1\| PREDICTED: aldo-keto reductase family 1, member C1 isoform 5 [Macac...	0.0	[5..311]	[1..323]
AK1C1_MACFA - Aldo-keto reductase family 1 member C1 homolog OS=Macaca fascicularis GN=AKR1C1 PE=1 SV=1	0.0	[5..311]	[1..323]
DHB5_MOUSE - Estradiol 17 beta-dehydrogenase 5 OS=Mus musculus GN=Akr1c6 PE=1 SV=1	0.0	[5..311]	[1..323]
gi\|60654665, gi\|... - gi\|60654667\|gb\|AAX31898.1\| aldo-keto reductase family 1 member C1 [synthetic construct], gi\|60654665... AKR1C1 - aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxyster...	0.0	[5..311]	[1..323]
PGFS1_BOVIN - Prostaglandin F synthase 1 OS=Bos taurus PE=1 SV=3	0.0	[5..311]	[1..323]
PE2R_RABIT - Prostaglandin-E(2) 9-reductase OS=Oryctolagus cuniculus GN=AKR1C5 PE=1 SV=1	0.0	[5..311]	[1..323]

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Predicted Domain #1

Region A:
Residues: [1-312]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPATLHDSTK ILSLNTGAQI PQIGLGTWQS KENDAYKAVL TALKDGYRHI DTAAIYRNED  60
   61 QVGQAIKDSG VPREEIFVTT KLWCTQHHEP EVALDQSLKR LGLDYVDLYL MHWPARLDPA 120
  121 YIKNEDILSV PTKKDGSRAV DITNWNFIKT WELMQELPKT GKTKAVGVSN FSINNLKDLL 180
  181 ASQGNKLTPA ANQVEIHPLL PQDELINFCK SKGIVVEAYS PLGSTDAPLL KEPVILEIAK 240
  241 KNNVQPGHVV ISWHVQRGYV VLPKSVNPDR IKTNRKIFTL STEDFEAINN ISKEKGEKRV 300
  301 VHPNWSPFEV FK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	686.758605
Match:	2alr__
Description:	Aldose reductase (aldehyde reductase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aldehyde reductase activity	5.07106269693426	bayes_pls_golite062009
L-glucuronate reductase activity	4.06568552614053	bayes_pls_golite062009
arabinose reductase activity	3.28910924444005	bayes_pls_golite062009
xylose reductase activity	3.28910924444005	bayes_pls_golite062009
glucose 1-dehydrogenase (NADP+) activity	2.68048267823456	bayes_pls_golite062009
aldo-keto reductase activity	2.57303336304449	bayes_pls_golite062009
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	2.43245618396666	bayes_pls_golite062009
3-alpha-hydroxysteroid dehydrogenase (B-specific) activity	2.43245618396666	bayes_pls_golite062009
alpha-keto ester reductase activity	2.31616201247794	bayes_pls_golite062009
alpha-keto amide reductase activity	2.31616201247794	bayes_pls_golite062009
steroid dehydrogenase activity	2.19555484888528	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.87468990921314	bayes_pls_golite062009
catalytic activity	1.68179794468736	bayes_pls_golite062009
glucose 1-dehydrogenase activity	1.55697325009049	bayes_pls_golite062009
bile acid transmembrane transporter activity	1.47447940903315	bayes_pls_golite062009
monocarboxylic acid transmembrane transporter activity	1.45034485133104	bayes_pls_golite062009
binding	1.3044513338497	bayes_pls_golite062009
bile acid binding	1.28757511368757	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
oxidoreductase activity	1.22645031212774	bayes_pls_golite062009
organic acid transmembrane transporter activity	1.20678148401125	bayes_pls_golite062009
carboxylic acid transmembrane transporter activity	1.19919645230426	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-CH group of donors	1.15597377782029	bayes_pls_golite062009
3-oxo-5-beta-steroid 4-dehydrogenase activity	1.15597377782029	bayes_pls_golite062009
protein binding	1.06359558718341	bayes_pls_golite062009
transmembrane transporter activity	1.03420335553507	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.868027162240181	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.86591084281532	bayes_pls_golite062009
substrate-specific transporter activity	0.783004917746429	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.544360068128604	bayes_pls_golite062009
ion transmembrane transporter activity	0.260605752589411	bayes_pls_golite062009
cation transmembrane transporter activity	0.0547047948210824	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: