YRC Public Data Repository - Protein Structure Prediction

Protein:	RIO1
Organism:	Saccharomyces cerevisiae
Length:	484 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RIO1.

Description	E-value	Query Range	Subject Range
RIO1 - Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into m... gi\|151945741 - gi\|151945741\|gb\|EDN63982.1\| homoserine kinase [Saccharomyces cerevisiae YJM789] gi\|207341148 - gi\|207341148\|gb\|EDZ69280.1\| YOR119Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190407448 - gi\|190407448\|gb\|EDV10715.1\| protein serine kinase [Saccharomyces cerevisiae RM11-1a] RIO1_YEAST - Serine/threonine-protein kinase RIO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RIO...	0.0	[1..464]	[1..464]
gi\|16549132 - gi\|16549132\|dbj\|BAB70761.1\| unnamed protein product [Homo sapiens]	2.0E-90	[12..434]	[97..522]
gi\|2338556 - gi\|2338556\|gb\|AAC26079.1\| extragenic suppressor of the bimD6 mutation [Emericella nidulans] gi\|40739557, gi\|... - gi\|67540386\|ref\|XP_663967.1\| hypothetical protein AN6363.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	9.0E-86	[23..484]	[122..557]
gi\|220945868, gi... - gi\|220955540\|gb\|ACL90313.1\| CG11660-PA [synthetic construct], gi\|220945868\|gb\|ACL85477.1\| CG11660-PA... CG11660-PB, CG11... - This gene is referred to in FlyBase by the symbol Dmel\CG11660 (CG11660, FBgn0036187). It is a prote...	3.0E-83	[9..464]	[114..565]
RIO1_SCHPO - Serine/threonine-protein kinase rio1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rio1 ... SPAC10F6.10 - protein kinase, RIO family	7.0E-80	[44..484]	[112..521]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	5.0E-76	[98..483]	[1..382]

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Predicted Domain #1

Region A:
Residues: [1-103]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEDKFDSL SVSQGASDHI NNQLLEKYSH KIKTDELSFS RAKTSKDKAN RATVENVLDP  60
   61 RTMRFLKSMV TRGVIADLNG CLSTGKEANV YHAFAGTGKA PVI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.69897
Match:	2ptk__
Description:	c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [104-200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEETGQYEVL ETDGSRAEYA IKIYKTSILV FKDRERYVDG EFRFRNSRSQ HNPRKMIKIW  60
   61 AEKEFRNLKR IYQSGVIPAP KPIEVKNNVL VMEFLSR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.0
Match:	1a06__
Description:	Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [201-417]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNGFASPKLK DYPYKNRDEI FHYYHTMVAY MRLLYQVCRL VHADLSEYNT IVHDDKLYMI  60
   61 DVSQSVEPEH PMSLDFLRMD IKNVNLYFEK MGISIFPERV IFQFVISETL EKFKGDYNNI 120
  121 SALVAYIASN LPIKSTEQDE AEDEIFRSLH LVRSLGGLEE RDFDRYTDGK FDLLKSLIAH 180
  181 DNERNFAASE QFEFDNADHE CSSGTEEFSD DEEDGSS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.0
Match:	1a06__
Description:	Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [418-484]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSEEDDEEEG EYYDDDEPKV LKGKKHEDKD LKKLRKQEAK DAKREKRKTK VKKHIKKKLV  60
   61 KKTKSKK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits