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View Structure Prediction Details

Protein: RIO1
Organism: Saccharomyces cerevisiae
Length: 484 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RIO1.

Description E-value Query
Range
Subject
Range
RIO1 - Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into m...
gi|151945741 - gi|151945741|gb|EDN63982.1| homoserine kinase [Saccharomyces cerevisiae YJM789]
gi|207341148 - gi|207341148|gb|EDZ69280.1| YOR119Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190407448 - gi|190407448|gb|EDV10715.1| protein serine kinase [Saccharomyces cerevisiae RM11-1a]
RIO1_YEAST - Serine/threonine-protein kinase RIO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RIO...
0.0 [1..464] [1..464]
gi|16549132 - gi|16549132|dbj|BAB70761.1| unnamed protein product [Homo sapiens]
2.0E-90 [12..434] [97..522]
gi|2338556 - gi|2338556|gb|AAC26079.1| extragenic suppressor of the bimD6 mutation [Emericella nidulans]
gi|40739557, gi|... - gi|67540386|ref|XP_663967.1| hypothetical protein AN6363.2 [Aspergillus nidulans FGSC A4], ref|XP_41...
9.0E-86 [23..484] [122..557]
gi|220945868, gi... - gi|220955540|gb|ACL90313.1| CG11660-PA [synthetic construct], gi|220945868|gb|ACL85477.1| CG11660-PA...
CG11660-PB, CG11... - This gene is referred to in FlyBase by the symbol Dmel\CG11660 (CG11660, FBgn0036187). It is a prote...
3.0E-83 [9..464] [114..565]
RIO1_SCHPO - Serine/threonine-protein kinase rio1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rio1 ...
SPAC10F6.10 - protein kinase, RIO family
7.0E-80 [44..484] [112..521]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-76 [98..483] [1..382]

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Predicted Domain #1
Region A:
Residues: [1-103]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEDKFDSL SVSQGASDHI NNQLLEKYSH KIKTDELSFS RAKTSKDKAN RATVENVLDP  60
   61 RTMRFLKSMV TRGVIADLNG CLSTGKEANV YHAFAGTGKA PVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 2ptk__
Description: c-src protein tyrosine kinase; c-src tyrosine kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [104-200]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEETGQYEVL ETDGSRAEYA IKIYKTSILV FKDRERYVDG EFRFRNSRSQ HNPRKMIKIW  60
   61 AEKEFRNLKR IYQSGVIPAP KPIEVKNNVL VMEFLSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.0
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [201-417]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNGFASPKLK DYPYKNRDEI FHYYHTMVAY MRLLYQVCRL VHADLSEYNT IVHDDKLYMI  60
   61 DVSQSVEPEH PMSLDFLRMD IKNVNLYFEK MGISIFPERV IFQFVISETL EKFKGDYNNI 120
  121 SALVAYIASN LPIKSTEQDE AEDEIFRSLH LVRSLGGLEE RDFDRYTDGK FDLLKSLIAH 180
  181 DNERNFAASE QFEFDNADHE CSSGTEEFSD DEEDGSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.0
Match: 1a06__
Description: Calmodulin-dependent protein kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [418-484]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSEEDDEEEG EYYDDDEPKV LKGKKHEDKD LKKLRKQEAK DAKREKRKTK VKKHIKKKLV  60
   61 KKTKSKK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.335 a.4.5 "Winged helix" DNA-binding domain
View Download 0.443 a.16.1 S15/NS1 RNA-binding domain
View Download 0.412 a.2.7 tRNA-binding arm
View Download 0.347 a.126.1 Serum albumin-like
View Download 0.476 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.311 a.47.2 t-snare proteins
View Download 0.277 a.101.1 Uteroglobin-like
View Download 0.262 d.47.1 Ribosomal protein L11, N-terminal domain
View Download 0.257 g.57.1 Serine proteinase inhibitor lekti
View Download 0.233 a.46.1 Methionine synthase domain
View Download 0.233 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.232 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.230 f.13.1 Family A G protein-coupled receptor-like
View Download 0.223 a.2.3 Chaperone J-domain
View Download 0.205 f.30.1 Photosystem I reaction center subunit X, PsaK


YRC Informatics Platform - Version 3.0
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