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View Structure Prediction Details

Protein: DIA2
Organism: Saccharomyces cerevisiae
Length: 746 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DIA2.

Description E-value Query
Range
Subject
Range
DIA2 - Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays...
0.0 [1..746] [1..746]
gi|13277819 - gi|13277819|gb|AAH03794.1| Stress-induced phosphoprotein 1 [Mus musculus]
8.0E-4 [36..208] [367..513]
STIP1_RAT - Stress-induced-phosphoprotein 1 OS=Rattus norvegicus GN=Stip1 PE=1 SV=1
8.0E-4 [36..208] [367..513]
STIP1_CRIGR - Stress-induced-phosphoprotein 1 OS=Cricetulus griseus GN=STIP1 PE=2 SV=1
0.001 [36..208] [367..513]
FBL8_ARATH - Putative F-box/LRR-repeat protein 8 OS=Arabidopsis thaliana GN=FBL8 PE=3 SV=1
0.001 [164..251] [10..104]
gi|61356797, gi|... - gi|61356797|gb|AAX41286.1| stress-induced-phosphoprotein 1 [synthetic construct], gi|61356792|gb|AAX...
STIP1 - stress-induced-phosphoprotein 1
gi|114638257 - gi|114638257|ref|XP_508521.2| PREDICTED: stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing pro...
0.002 [36..208] [367..513]
sti-1 - status:Confirmed UniProt:O16259 protein_id:AAG24172.1
0.005 [36..206] [147..288]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKFITKNK KYTPMSSPGN SGVAIDSTVL KAIELGTRLF KSGEYLQAKR IFTNALRVCD  60
   61 SYSQEQIMRI RNAYQLDTAR PDNKRLYHPR YIKILDNICA CYEKLNDLKS CLDVSQRLLK 120
  121 LEPGNIKCYI RCTRTLIKLK DWKRAYKTCS RGLQLCNNDS NHLRQQKQFI KNNMVQKQDG 180
  181 KRSYIDPLEE TKIAKKKKNN NVLESLPKKK IKGST

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.61
Match: 1qqeA
Description: Vesicular transport protein sec17
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
catalytic activity 0.838457647933563 bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity 0.788209490718562 bayes_pls_golite062009
cis-trans isomerase activity 0.728844238348547 bayes_pls_golite062009
binding 0.436537606536136 bayes_pls_golite062009
transcription regulator activity 0.238548113422564 bayes_pls_golite062009
protein binding 0.218634943775696 bayes_pls_golite062009
protein kinase activity 0.0817192853858701 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0284131677759829 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [216-266]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKTDLVGNLP IEILPIIFQR FTTKELVTLS LVCNKWRDKI LYHLDCFQEF N

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 3.05061
Match: PF00646
Description: F-box domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [267-610]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAPINFKNFV KFMDFLQQNF TRTYRKYILS QVKVSSRITS EELRITQLLF SKMPKCINIE  60
   61 RLILSMPTLT TTQIFKLMVR GGTDFFTRLL ELSLMITYRP DKQHELEILQ TCPLLKKIEL 120
  121 IFVNSLVPIF DGNNSVGRDG SFNVMARHTN MQISTADNDE QGIVEEKVIY SELEKITLIC 180
  181 DKKKIKNFPL CRALLRGQFP LLQKLTITGV TFPMNNQDIM NFQWLLNFPD LKELWIEDND 240
  241 NCELSKFLQL LKFSNVWKNL EKLTFRENKL YPIVNLDEDQ PVTNDDEVPS MLFYKENLQN 300
  301 LEKLDLMGTS ISGSALTRLC EQEYLDGRKL RSLNIGNCPN IQFP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [611-746]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNHAHTARMI LDVNAVLKRL SKLEEINLSH LSSLNDSTMK SFIINVPFLE NLKRLDISHN  60
   61 FEITGISIYE FLKKFQMDHD NEAGGQPLAY LNIDGCSQVS HITVNMIRAQ NLVTQVDCVY 120
  121 ERDVWRKFGI NSYSYS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.562 0.392 invasive growth in response to glucose limitation a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.601 0.026 invasive growth in response to glucose limitation a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.547 0.015 invasive growth in response to glucose limitation a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.560 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.490 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.438 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.424 N/A N/A a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.403 N/A N/A d.198.1 Type III secretory system chaperone
View Download 0.384 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.369 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.365 N/A N/A a.24.11 Bacterial GAP domain
View Download 0.363 N/A N/A d.106.1 Sterol carrier protein, SCP
View Download 0.351 N/A N/A a.74.1 Cyclin-like
View Download 0.345 N/A N/A a.39.1 EF-hand
View Download 0.336 N/A N/A d.58.39 Glutamyl tRNA-reductase catalytic, N-terminal domain
View Download 0.326 N/A N/A a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.324 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.323 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.322 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.303 N/A N/A a.5.3 N-terminal domain of phosphatidylinositol transfer protein sec14p
View Download 0.296 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.296 N/A N/A a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.285 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.280 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.279 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.257 N/A N/A a.177.1 Sigma2 domain of RNA polymerase sigma factors
View Download 0.253 N/A N/A a.78.1 Fatty acid responsive transcription factor FadR, C-terminal domain
View Download 0.249 N/A N/A c.66.1 S-adenosyl-L-methionine-dependent methyltransferases
View Download 0.234 N/A N/A a.47.2 t-snare proteins
View Download 0.221 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.216 N/A N/A d.162.1 LDH C-terminal domain-like
View Download 0.215 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.213 N/A N/A a.29.2 Bromodomain
View Download 0.206 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases


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