YRC Public Data Repository - Protein Structure Prediction

Protein:	BDS1
Organism:	Saccharomyces cerevisiae
Length:	646 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BDS1.

Description	E-value	Query Range	Subject Range
BDS1 - Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources BDS1_YEAST - Alkyl/aryl-sulfatase BDS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BDS1 PE=1 SV=1	0.0	[1..646]	[1..646]
gi\|16503049, gi\|... - gi\|25324459\|pir\|\|AB0731 probable hydrolase STY2004 [imported] - Salmonella enterica subsp. enterica ... gi\|29141490, gi\|... - gi\|29141490\|ref\|NP_804832.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typhi s... gi\|213581982 - gi\|213581982\|ref\|ZP_03363808.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typh... gi\|213648150 - gi\|213648150\|ref\|ZP_03378203.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typh... gi\|16760752 - gi\|16760752\|ref\|NP_456369.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typhi s... gi\|213424176 - gi\|213424176\|ref\|ZP_03357041.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typh...	0.0	[12..641]	[26..659]
gi\|99031939, gi\|... - gi\|99031941\|pdb\|2CG2\|A Chain A, Crystal Structure Of Sdsa1, An Alkylsulfatase From Pseudomonas Aerug... gi\|9946626, gi\|1... - gi\|9946626\|gb\|AAG04129.1\|AE004509_4 SDS hydrolase SdsA1 [Pseudomonas aeruginosa PAO1], gi\|15595937\|r...	0.0	[10..645]	[17..656]
gi\|16209567 - gi\|16209567\|gb\|AAL14236.1\| cddY [Rhodococcus ruber]	0.0	[16..641]	[5..631]
gi\|15640802, gi\|... - gi\|9655231\|gb\|AAF93948.1\| conserved hypothetical protein [Vibrio cholerae O1 biovar El Tor str. N169... gi\|11280001 - pir\|\|H82281 conserved hypothetical protein VC0783 [imported] - Vibrio cholerae (strain N16961 serogr... gi\|121585760, gi... - gi\|121585760\|ref\|ZP_01675555.1\| conserved hypothetical protein [Vibrio cholerae 2740-80], gi\|1215501... gi\|153220724, gi... - gi\|153220724\|ref\|ZP_01951835.1\| conserved hypothetical protein [Vibrio cholerae MAK 757], gi\|1241202... gi\|229371276, gi... - gi\|229608621\|ref\|YP_002879269.1\| alkyl sulfatase [Vibrio cholerae MJ-1236], gi\|229371276\|gb\|ACQ61699... gi\|126512208, gi... - gi\|153817292\|ref\|ZP_01969959.1\| conserved hypothetical protein [Vibrio cholerae NCTC 8457], gi\|12651... gi\|229344562, gi... - gi\|229517847\|ref\|ZP_04407291.1\| alkyl sulfatase [Vibrio cholerae RC9], gi\|229344562\|gb\|EEO09536.1\| a... gi\|229350691, gi... - gi\|229510726\|ref\|ZP_04400205.1\| alkyl sulfatase [Vibrio cholerae B33], gi\|229350691\|gb\|EEO15632.1\| a... gi\|229357825, gi... - gi\|229505602\|ref\|ZP_04395112.1\| alkyl sulfatase [Vibrio cholerae BX 330286], gi\|229357825\|gb\|EEO2274... gi\|227080962, gi... - gi\|227080962\|ref\|YP_002809513.1\| hypothetical protein VCM66_0741 [Vibrio cholerae M66-2], gi\|2270088... gi\|75831975, gi\|... - gi\|75831975\|ref\|ZP_00761234.1\| COG2015: Alkyl sulfatase and related hydrolases [Vibrio cholerae MO10... gi\|146315275, gi... - gi\|75826131\|ref\|ZP_00755566.1\| COG2015: Alkyl sulfatase and related hydrolases [Vibrio cholerae O395...	0.0	[17..644]	[30..660]
gi\|396418 - gi\|396418\|gb\|AAC43177.1\| ORF_f665 [Escherichia coli str. K-12 substr. MG1655] gi\|396418\|gb\|AAC... - ORF_f665 [Escherichia coli]	0.0	[8..641]	[29..664]
gi\|2367350, gi\|1... - gb\|AAC77044.1\| orf, hypothetical protein; putative enzyme [Escherichia coli K12], gi\|16131909\|ref\|N... gi\|7449649 - gi\|7449649\|pir\|\|B65217 hypothetical 73.7 kD protein in fdhF-phnP intergenic region - Escherichia col...	0.0	[8..641]	[29..664]
gi\|15834320, gi\|... - gi\|15834320\|ref\|NP_313093.1\| hypothetical protein ECs5066 [Escherichia coli O157:H7], gi\|13364543\|db... gi\|209750976, gi... - pir\|\|B91262 hypothetical protein ECs5066 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|15834320, gi\|... - gi\|15834320\|ref\|NP_313093.1\| hypothetical protein ECs5066 [Escherichia coli O157:H7 str. Sakai], gi\|...	0.0	[8..641]	[29..664]
gi\|12519043, gi\|... - gi\|15804675\|ref\|NP_290716.1\| hypothetical protein Z5683 [Escherichia coli O157:H7 EDL933], gi\|125190... gi\|25324457 - pir\|\|E86102 hypothetical protein yjcS [imported] - Escherichia coli (strain O157:H7, substrain EDL9...	0.0	[8..641]	[29..664]

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Predicted Domain #1

Region A:
Residues: [1-80]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGAFKRNRG SSQSFAKECQ PSTLKANLEV AKELPFSDRR DFEDATQGYI GSLSDEQIIG  60
   61 PDGGVVWCMK SYGFLEPETP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
alkyl sulfatase activity	1.69609271133145	bayes_pls_golite062009
hydroxyacylglutathione hydrolase activity	1.565406918731	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [81-254]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANTVNPSLWR QAQLNAIHGL FKITDNVYQV RGLDISNMTI IEGNTSLIII DTLFTTETAQ  60
   61 ESLKLYYRHR PQKPVRTVIY THSHSDHYGG VKGIVKEADV KSGEVQIIAP VGFMESVVAE 120
  121 NILAGNAMHR RSQYQFGMLL SPSVKGHVDC GIGKAASHGT VTLIAPTIII EEPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.980454
Match:	1bc2A_
Description:	Zn metallo-beta-lactamase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [255-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EERTIDGVDF VFQLAPGSEA PSEMLIYMPQ QRVLNMAEDV THHMHNLYAL RGVEVRDGNQ  60
   61 WAKYIDAARV AFGSKTDVLI AQHHWPTTGQ MRINELLKKQ RDMYKFIHDQ TLRLLNQG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.980454
Match:	1bc2A_
Description:	Zn metallo-beta-lactamase
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [373-427]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTSRDIAETL RMPSSLEQEW STRGYYGTLS HNVKAVYQKY LGWYDANPAN LNPLP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [428-516]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVAYAKKAVE YMGGADAVLA RAYKDFQKGE FRWVASVVNQ LVFADPNNHQ ARELCADALE  60
   61 QLGYQAEAST WRNAYLVGAM ELRQGVPKR

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.3
Match:	1hxiA
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [517-646]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSTGKRNNIA VLNNEMFFDF LAVRLNATKA EGKIIVSNWC FINSNERFVI TLENCALTYI  60
   61 QGWQTDADAT ITLKRTTFEA LLANEITMVD FLRSKEVEIE GNRLRIEELL KLFDDFDQSF 120
  121 PVVEPMGGST

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.69897
Match:	1iktA_
Description:	SCP2-like domain of MFE-2
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: