YRC Public Data Repository - Protein Structure Prediction

Protein:	BDS1
Organism:	Saccharomyces cerevisiae
Length:	646 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BDS1.

Description	E-value	Query Range	Subject Range
BDS1 - Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources BDS1_YEAST - Alkyl/aryl-sulfatase BDS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BDS1 PE=1 SV=1	0.0	[1..646]	[1..646]
gi\|16503049, gi\|... - gi\|25324459\|pir\|\|AB0731 probable hydrolase STY2004 [imported] - Salmonella enterica subsp. enterica ... gi\|29141490, gi\|... - gi\|29141490\|ref\|NP_804832.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typhi s... gi\|213581982 - gi\|213581982\|ref\|ZP_03363808.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typh... gi\|213648150 - gi\|213648150\|ref\|ZP_03378203.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typh... gi\|16760752 - gi\|16760752\|ref\|NP_456369.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typhi s... gi\|213424176 - gi\|213424176\|ref\|ZP_03357041.1\| putative hydrolase [Salmonella enterica subsp. enterica serovar Typh...	0.0	[12..641]	[26..659]
gi\|99031939, gi\|... - gi\|99031941\|pdb\|2CG2\|A Chain A, Crystal Structure Of Sdsa1, An Alkylsulfatase From Pseudomonas Aerug... gi\|9946626, gi\|1... - gi\|9946626\|gb\|AAG04129.1\|AE004509_4 SDS hydrolase SdsA1 [Pseudomonas aeruginosa PAO1], gi\|15595937\|r...	0.0	[10..645]	[17..656]
gi\|16209567 - gi\|16209567\|gb\|AAL14236.1\| cddY [Rhodococcus ruber]	0.0	[16..641]	[5..631]
gi\|15640802, gi\|... - gi\|9655231\|gb\|AAF93948.1\| conserved hypothetical protein [Vibrio cholerae O1 biovar El Tor str. N169... gi\|11280001 - pir\|\|H82281 conserved hypothetical protein VC0783 [imported] - Vibrio cholerae (strain N16961 serogr... gi\|121585760, gi... - gi\|121585760\|ref\|ZP_01675555.1\| conserved hypothetical protein [Vibrio cholerae 2740-80], gi\|1215501... gi\|153220724, gi... - gi\|153220724\|ref\|ZP_01951835.1\| conserved hypothetical protein [Vibrio cholerae MAK 757], gi\|1241202... gi\|229371276, gi... - gi\|229608621\|ref\|YP_002879269.1\| alkyl sulfatase [Vibrio cholerae MJ-1236], gi\|229371276\|gb\|ACQ61699... gi\|126512208, gi... - gi\|153817292\|ref\|ZP_01969959.1\| conserved hypothetical protein [Vibrio cholerae NCTC 8457], gi\|12651... gi\|229344562, gi... - gi\|229517847\|ref\|ZP_04407291.1\| alkyl sulfatase [Vibrio cholerae RC9], gi\|229344562\|gb\|EEO09536.1\| a... gi\|229350691, gi... - gi\|229510726\|ref\|ZP_04400205.1\| alkyl sulfatase [Vibrio cholerae B33], gi\|229350691\|gb\|EEO15632.1\| a... gi\|229357825, gi... - gi\|229505602\|ref\|ZP_04395112.1\| alkyl sulfatase [Vibrio cholerae BX 330286], gi\|229357825\|gb\|EEO2274... gi\|227080962, gi... - gi\|227080962\|ref\|YP_002809513.1\| hypothetical protein VCM66_0741 [Vibrio cholerae M66-2], gi\|2270088... gi\|75831975, gi\|... - gi\|75831975\|ref\|ZP_00761234.1\| COG2015: Alkyl sulfatase and related hydrolases [Vibrio cholerae MO10... gi\|146315275, gi... - gi\|75826131\|ref\|ZP_00755566.1\| COG2015: Alkyl sulfatase and related hydrolases [Vibrio cholerae O395...	0.0	[17..644]	[30..660]
gi\|396418 - gi\|396418\|gb\|AAC43177.1\| ORF_f665 [Escherichia coli str. K-12 substr. MG1655] gi\|396418\|gb\|AAC... - ORF_f665 [Escherichia coli]	0.0	[8..641]	[29..664]
gi\|2367350, gi\|1... - gb\|AAC77044.1\| orf, hypothetical protein; putative enzyme [Escherichia coli K12], gi\|16131909\|ref\|N... gi\|7449649 - gi\|7449649\|pir\|\|B65217 hypothetical 73.7 kD protein in fdhF-phnP intergenic region - Escherichia col...	0.0	[8..641]	[29..664]
gi\|15834320, gi\|... - gi\|15834320\|ref\|NP_313093.1\| hypothetical protein ECs5066 [Escherichia coli O157:H7], gi\|13364543\|db... gi\|209750976, gi... - pir\|\|B91262 hypothetical protein ECs5066 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|15834320, gi\|... - gi\|15834320\|ref\|NP_313093.1\| hypothetical protein ECs5066 [Escherichia coli O157:H7 str. Sakai], gi\|...	0.0	[8..641]	[29..664]
gi\|12519043, gi\|... - gi\|15804675\|ref\|NP_290716.1\| hypothetical protein Z5683 [Escherichia coli O157:H7 EDL933], gi\|125190... gi\|25324457 - pir\|\|E86102 hypothetical protein yjcS [imported] - Escherichia coli (strain O157:H7, substrain EDL9...	0.0	[8..641]	[29..664]

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Predicted Domain #1

Region A:
Residues: [1-80]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGAFKRNRG SSQSFAKECQ PSTLKANLEV AKELPFSDRR DFEDATQGYI GSLSDEQIIG  60
   61 PDGGVVWCMK SYGFLEPETP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.742	a.23.5	Hemolysin expression modulating protein HHA
View	Download	0.374	a.49.1	C-terminal domain of B transposition protein
View	Download	0.345	a.2.3	Chaperone J-domain
View	Download	0.343	a.28.2	Colicin E immunity proteins
View	Download	0.324	a.2.3	Chaperone J-domain
View	Download	0.305	a.4.1	Homeodomain-like
View	Download	0.270	a.23.4	Mitochondrial import receptor subunit Tom20
View	Download	0.256	a.71.1	Endoplasmic reticulum protein ERP29, C-domain
View	Download	0.249	a.46.1	Methionine synthase domain
View	Download	0.230	d.226.1	GIY-YIG endonuclease
View	Download	0.217	a.64.1	Saposin
View	Download	0.204	c.98.2	HPr kinase/phoshatase HprK N-terminal domain

Predicted functions:

Term	Confidence	Notes
alkyl sulfatase activity	1.69609271133145	bayes_pls_golite062009
hydroxyacylglutathione hydrolase activity	1.565406918731	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [81-254]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANTVNPSLWR QAQLNAIHGL FKITDNVYQV RGLDISNMTI IEGNTSLIII DTLFTTETAQ  60
   61 ESLKLYYRHR PQKPVRTVIY THSHSDHYGG VKGIVKEADV KSGEVQIIAP VGFMESVVAE 120
  121 NILAGNAMHR RSQYQFGMLL SPSVKGHVDC GIGKAASHGT VTLIAPTIII EEPV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.980454
Match:	1bc2A_
Description:	Zn metallo-beta-lactamase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [255-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EERTIDGVDF VFQLAPGSEA PSEMLIYMPQ QRVLNMAEDV THHMHNLYAL RGVEVRDGNQ  60
   61 WAKYIDAARV AFGSKTDVLI AQHHWPTTGQ MRINELLKKQ RDMYKFIHDQ TLRLLNQG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	43.980454
Match:	1bc2A_
Description:	Zn metallo-beta-lactamase
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [373-427]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YTSRDIAETL RMPSSLEQEW STRGYYGTLS HNVKAVYQKY LGWYDANPAN LNPLP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.622	a.44.1	Disulphide-bond formation facilitator (DSBA), insertion domain
View	Download	0.567	a.144.1	PABC (PABP) domain
View	Download	0.558	a.4.1	Homeodomain-like
View	Download	0.521	a.8.1	Bacterial immunoglobulin/albumin-binding domains
View	Download	0.506	a.5.2	UBA-like
View	Download	0.438	d.58.24	CheY-binding domain of CheA
View	Download	0.419	a.35.1	lambda repressor-like DNA-binding domains
View	Download	0.412	a.6.1	Putative DNA-binding domain
View	Download	0.397	a.77.1	DEATH domain
View	Download	0.381	a.5.1	DNA helicase RuvA subunit, C-terminal domain
View	Download	0.380	a.5.2	UBA-like
View	Download	0.330	a.108.1	Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View	Download	0.310	a.5.7	4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View	Download	0.305	f.13.1	Family A G protein-coupled receptor-like
View	Download	0.297	a.5.1	DNA helicase RuvA subunit, C-terminal domain
View	Download	0.290	a.60.1	SAM/Pointed domain
View	Download	0.288	g.41.5	Rubredoxin-like
View	Download	0.273	a.6.1	Putative DNA-binding domain
View	Download	0.270	a.5.2	UBA-like
View	Download	0.263	a.5.2	UBA-like
View	Download	0.249	a.60.11	Hypothetical protein YjbJ
View	Download	0.224	d.10.1	DNA-binding domain
View	Download	0.220	a.28.1	ACP-like

Predicted Domain #5

Region A:
Residues: [428-516]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVAYAKKAVE YMGGADAVLA RAYKDFQKGE FRWVASVVNQ LVFADPNNHQ ARELCADALE  60
   61 QLGYQAEAST WRNAYLVGAM ELRQGVPKR

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.3
Match:	1hxiA
Description:	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [517-646]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSTGKRNNIA VLNNEMFFDF LAVRLNATKA EGKIIVSNWC FINSNERFVI TLENCALTYI  60
   61 QGWQTDADAT ITLKRTTFEA LLANEITMVD FLRSKEVEIE GNRLRIEELL KLFDDFDQSF 120
  121 PVVEPMGGST

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.69897
Match:	1iktA_
Description:	SCP2-like domain of MFE-2
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: