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View Structure Prediction Details

Protein: PFK27
Organism: Saccharomyces cerevisiae
Length: 397 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PFK27.

Description E-value Query
Range
Subject
Range
6P22_YEAST - 6-phosphofructo-2-kinase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PFK27 PE=1 SV...
PFK27 - 6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenol...
gi|207341472 - gi|207341472|gb|EDZ69520.1| YOL136Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190407217 - gi|190407217|gb|EDV10484.1| 6-phosphofructo-2-kinase [Saccharomyces cerevisiae RM11-1a]
0.0 [1..397] [1..397]
gi|162463489, gi... - gi|162463489|ref|NP_001105044.1| fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase [Zea mays...
6.0E-88 [4..326] [253..548]
gi|14149116 - gi|14149116|dbj|BAB55655.1| fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase [Bruguiera gym...
1.0E-87 [7..326] [256..539]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-86 [11..326] [17..296]
F261_RAT - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 OS=Rattus norvegicus GN=Pfkfb1 PE=1 SV=3
4.0E-86 [59..326] [1..239]
PFKFB1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
1.0E-85 [59..326] [1..239]
F26_LITCT - 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1
1.0E-85 [65..326] [6..238]
gi|18251459 - gi|18251459|gb|AAL66023.1| fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase [Oryza sativa]
1.0E-85 [13..326] [260..548]

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Predicted Domain #1
Region A:
Residues: [1-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGSSDSDSH DGYLTSEYNS SNSLFSLNTG NSYSSASLDR ATLDCQDSVF FDNHKSSLLS  60
   61 TEVPRFISND PLHLPITLNY KRDNADPTYT NGKVNKFMIV LIGLPATGKS TISSHLIQCL 120
  121 KNNPLTNSLR CKVFNAGKIR RQISCATISK PLLLSNTSSE DLFNPKNNDK KETYARITLQ 180
  181 KLFHEINNDE CDVGIFDATN STIERRRFIF EEVCSFNTDE LSSFNLVPII LQVSCFNRSF 240
  241 IKYNIHNKSF NEDYLDKPYE LAIKDFAKRL KHYYSQFTPF SLDEFNQIHR YISQHEEIDT 300
  301 SLFFFNVINA GVVEPHSLNQ SHYPSTC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 152.211549
Match: 2bifA_
Description: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, kinase domain; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, phosphatase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [328-397]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKQIRDTIMV IENFINHYSQ MFGFEYIEAV KLFFESFGNS SEETLTTLDS VVNDKFFDDL  60
   61 QSLIESNGFA 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.881 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain


YRC Informatics Platform - Version 3.0
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