| Protein: | MSH2 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 964 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSH2.
| Description | E-value | Query Range |
Subject Range |
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0.0 | [1..964] | [1..964] |
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0.0 | [3..960] | [2..931] |
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0.0 | [3..960] | [2..931] |
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0.0 | [3..960] | [2..931] |
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0.0 | [3..887] | [2..859] |
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0.0 | [3..958] | [2..927] |
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0.0 | [11..937] | [7..854] |
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Region A: Residues: [1-118] |
1 11 21 31 41 51
| | | | | |
1 MSSTRPELKF SDVSEERNFY KKYTGLPKKP LKTIRLVDKG DYYTVIGSDA IFVADSVYHT 60
61 QSVLKNCQLD PVTAKNFHEP TKYVTVSLQV LATLLKLCLL DLGYKVEIYD KGWKLIKS
|
| Detection Method: |  |
| Confidence: | 1573.9794 |
| Match: | 1e3mA_ |
| Description: | DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [119-292] |
1 11 21 31 41 51
| | | | | |
1 ASPGNIEQVN ELMNMNIDSS IIIASLKVQW NSQDGNCIIG VAFIDTTAYK VGMLDIVDNE 60
61 VYSNLESFLI QLGVKECLVQ DLTSNSNSNA EMQKVINVID RCGCVVTLLK NSEFSEKDVE 120
121 LDLTKLLGDD LALSLPQKYS KLSMGACNAL IGYLQLLSEQ DQVGKYELVE HKLK
|
| Detection Method: | |
| Confidence: | 1573.9794 |
| Match: | 1e3mA_ |
| Description: | DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I |
| Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [293-336] |
1 11 21 31 41 51
| | | | | |
1 EFMKLDASAI KALNLFPQGP QNPFGSNNLA VSGFTSAGNS GKVT
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Region B: Residues: [631-883] |
1 11 21 31 41 51
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1 SYAPIPYIRP KLHPMDSERR THLISSRHPV LEMQDDISFI SNDVTLESGK GDFLIITGPN 60
61 MGGKSTYIRQ VGVISLMAQI GCFVPCEEAE IAIVDAILCR VGAGDSQLKG VSTFMVEILE 120
121 TASILKNASK NSLIIVDELG RGTSTYDGFG LAWAIAEHIA SKIGCFALFA THFHELTELS 180
181 EKLPNVKNMH VVAHIEKNLK EQKHDDEDIT LLYKVEPGIS DQSFGIHVAE VVQFPEKIVK 240
241 MAKRKANELD DLK
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| Detection Method: | |
| Confidence: | 1573.9794 |
| Match: | 1e3mA_ |
| Description: | DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I |
| Matching Structure (courtesy of the PDB): |
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Region A: Residues: [337-503] |
1 11 21 31 41 51
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1 SLFQLLNHCK TNAGVRLLNE WLKQPLTNID EINKRHDLVD YLIDQIELRQ MLTSEYLPMI 60
61 PDIRRLTKKL NKRGNLEDVL KIYQFSKRIP EIVQVFTSFL EDDSPTEPVN ELVRSVWLAP 120
121 LSHHVEPLSK FEEMVETTVD LDAYEENNEF MIKVEFNEEL GKIRSKL
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Region B: Residues: [583-630] |
1 11 21 31 41 51
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1 ILQKEYDKQQ SALVREIINI TLTYTPVFEK LSLVLAHLDV IASFAHTS
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| Detection Method: | |
| Confidence: | 1573.9794 |
| Match: | 1e3mA_ |
| Description: | DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I |
| Matching Structure (courtesy of the PDB): |
|
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Region A: Residues: [504-582] |
1 11 21 31 41 51
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1 DTLRDEIHSI HLDSAEDLGF DPDKKLKLEN HHLHGWCMRL TRNDAKELRK HKKYIELSTV 60
61 KAGIFFSTKQ LKSIANETN
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| Detection Method: | |
| Confidence: | 1573.9794 |
| Match: | 1e3mA_ |
| Description: | DNA repair protein MutS, domain III; DNA repair protein MutS, the C-terminal domain; DNA repair protein MutS, domain II; DNA repair protein MutS, domain I |
| Matching Structure (courtesy of the PDB): |
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Region A: Residues: [884-964] |
1 11 21 31 41 51
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1 TNNEDLKKAK LSLQEVNEGN IRLKALLKEW IRKVKEEGLH DPSKITEEAS QHKIQELLRA 60
61 IANEPEKEND NYLKYIKALL L
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| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
| MCM Score |
SCOP Match |
SCOP Description | ||
| View | Download | 0.754 | a.77.1 | DEATH domain |
| View | Download | 0.593 | a.74.1 | Cyclin-like |
| View | Download | 0.602 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.690 | a.57.1 | Protein HNS-dependent expression A; HdeA |
| View | Download | 0.652 | a.29.4 | RecG, N-terminal domain |
| View | Download | 0.571 | a.64.1 | Saposin |
| View | Download | 0.542 | a.64.1 | Saposin |
| View | Download | 0.535 | a.48.3 | Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 |
| View | Download | 0.511 | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.503 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.484 | a.16.1 | S15/NS1 RNA-binding domain |
| View | Download | 0.431 | a.112.1 | Description not found. |
| View | Download | 0.418 | d.43.1 | Elongation factor Ts (EF-Ts), dimerisation domain |
| View | Download | 0.417 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.414 | a.24.3 | Cytochromes |
| View | Download | 0.408 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.402 | a.24.3 | Cytochromes |
| View | Download | 0.400 | a.39.1 | EF-hand |
| View | Download | 0.393 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.391 | a.2.8 | Eukaryotic DNA topoisomerase I, dispensable insert domain |
| View | Download | 0.390 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.387 | a.4.12 | TrpR-like |
| View | Download | 0.386 | a.30.2 | Homodimeric domain of signal transducing histidine kinase |
| View | Download | 0.383 | a.74.1 | Cyclin-like |
| View | Download | 0.379 | a.29.2 | Bromodomain |
| View | Download | 0.370 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.342 | c.55.4 | Translational machinery components |
| View | Download | 0.339 | a.2.7 | tRNA-binding arm |
| View | Download | 0.336 | a.46.1 | Methionine synthase domain |
| View | Download | 0.321 | a.177.1 | Sigma2 domain of RNA polymerase sigma factors |
| View | Download | 0.318 | a.126.1 | Serum albumin-like |
| View | Download | 0.316 | a.64.1 | Saposin |
| View | Download | 0.315 | a.71.2 | Helical domain of Sec23/24 |
| View | Download | 0.314 | a.133.1 | Phospholipase A2, PLA2 |
| View | Download | 0.312 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.304 | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.302 | a.2.3 | Chaperone J-domain |
| View | Download | 0.300 | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.299 | a.77.1 | DEATH domain |
| View | Download | 0.298 | a.81.1 | N-terminal domain of DnaB helicase |
| View | Download | 0.298 | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.298 | a.105.1 | FIS-like |
| View | Download | 0.296 | a.7.7 | BAG domain |
| View | Download | 0.293 | a.64.1 | Saposin |
| View | Download | 0.293 | a.60.6 | DNA polymerase beta, N-terminal domain-like |
| View | Download | 0.287 | a.4.1 | Homeodomain-like |
| View | Download | 0.285 | a.24.4 | Hemerythrin |
| View | Download | 0.276 | a.12.1 | Kix domain of CBP (creb binding protein) |
| View | Download | 0.266 | a.4.1 | Homeodomain-like |
| View | Download | 0.263 | i.1.1 | Ribosome and ribosomal fragments |
| View | Download | 0.259 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.257 | a.29.2 | Bromodomain |
| View | Download | 0.256 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.253 | a.4.1 | Homeodomain-like |
| View | Download | 0.241 | a.76.1 | Iron-dependent represor protein, dimerization domain |
| View | Download | 0.241 | a.150.1 | Anti-sigma factor AsiA |
| View | Download | 0.238 | a.1.1 | Globin-like |
| View | Download | 0.235 | g.36.1 | Ferredoxin thioredoxin reductase (FTR), catalytic beta chain |
| View | Download | 0.235 | a.74.1 | Cyclin-like |
| View | Download | 0.231 | a.47.2 | t-snare proteins |
| View | Download | 0.231 | a.4.1 | Homeodomain-like |
| View | Download | 0.227 | a.47.2 | t-snare proteins |
| View | Download | 0.222 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.218 | a.4.6 | C-terminal effector domain of the bipartite response regulators |
| View | Download | 0.216 | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.214 | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.212 | a.4.1 | Homeodomain-like |
| View | Download | 0.206 | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.205 | a.23.4 | Mitochondrial import receptor subunit Tom20 |
| View | Download | 0.203 | d.216.1 | Rotavirus NSP2 fragment, N-terminal domain |
| View | Download | 0.203 | a.24.12 | Outer surface protein C (OspC) |
| View | Download | 0.202 | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.202 | a.44.1 | Disulphide-bond formation facilitator (DSBA), insertion domain |
| View | Download | 0.201 | a.1.1 | Globin-like |
| View | Download | 0.200 | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
