YRC Public Data Repository - Protein Structure Prediction

Protein:	HOL1
Organism:	Saccharomyces cerevisiae
Length:	586 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOL1.

Description	E-value	Query Range	Subject Range
gi\|151944583 - gi\|151944583\|gb\|EDN62861.1\| conserved protein [Saccharomyces cerevisiae YJM789] HOL1 - Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance tran... HOL1_YEAST - Protein HOL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOL1 PE=1 SV=1	2.0E-94	[1..586]	[1..586]
gi\|25308886, gi\|... - gi\|3859693\|emb\|CAA21968.1\| transport protein [Candida albicans], pir\|\|T52148 transport protein hol1 ...	1.0E-79	[3..586]	[16..586]
SPBC1271.10c - membrane transporter YHMA_SCHPO - Uncharacterized MFS-type transporter C1271.10c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...	6.0E-79	[11..584]	[8..561]
gi\|21225257, gi\|... - gi\|7649556\|emb\|CAB89031.1\| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi\|...	1.0E-72	[29..537]	[4..440]
gi\|223644446, gi... - gi\|241956766\|ref\|XP_002421103.1\| multidrug transporter; plasma membrane transporter of the major fac... gi\|2951670 - gi\|2951670\|emb\|CAA12730.1\| multidrug transporter [Candida dubliniensis]	4.0E-72	[2..575]	[50..556]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-70	[2..576]	[36..552]
CYHR_CANMA - Cycloheximide resistance protein OS=Candida maltosa GN=CYHR PE=3 SV=1	4.0E-70	[2..576]	[36..552]
gi\|19386936 - gi\|19386936\|gb\|AAL87047.1\|AF448056_3 putative dothistromin transporter [Mycosphaerella pini] gi\|19386936 - gi\|19386936\|gb\|AAL87047.1\|AF448056_3 putative dothistromin transporter [Mycosphaerella pini]	1.0E-68	[9..546]	[2..499]

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Predicted Domain #1

Region A:
Residues: [1-63]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKYTNRDHP DYIPGTFNIY SSQNLENGII YESKLKKTSS GVVLIPQPSY SPNDPLNWSS  60
   61 WRK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [64-505]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAHFGLMAFI TAFTAATSND AGAAQDSLNE IYGISYDSMN TGAGVLFLGI GWSTLFLAPF  60
   61 ANLYGRKITY IVCTTLGLFG ALWFALAKRT SDTIWSQLFV GISESCAEAQ VQLSLSDIFF 120
  121 QHQLGSVLTV YIMCTSIGTF LGPLIAGYIS AFTNFRWVGW VAVIISGGLL ITIIFGCEET 180
  181 YFDRGQYMTP LTSCQSGYED GTTLQNSDNT AVSRRKRHLD AKLSTPGAMG EKGVDLSETA 240
  241 EFEVNNEEEV TIPETRELID GSKEHLKPYP KRVAILTKAT NLKGYGFKQY FKYLKINLRM 300
  301 FLFPPVWLSG MFWGIQDVFL TFYLTTQESA YYEPPWNYSD FGVAIMNVPT LIGAVIGCIC 360
  361 AGIVSDYFVL WMARHNRGIL EAEFRLYFSI ATAIIGPAGL LMFGIGTARQ WPWQAIYVGL 420
  421 GFVGFAWGCS GDIAMAYLMD CY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	7.39794
Match:	1lviA_
Description:	No description for 1lviA_ was found.

Predicted Domain #3

Region A:
Residues: [506-586]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDMVLEGMVC TAIINNTISC IFTFTCSDWL AASGTENTYI ALAVINFGIT AFALPMYYYG  60
   61 KRIRLWTKRW YLQSVNLRDG V

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits