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View Structure Prediction Details

Protein: HOL1
Organism: Saccharomyces cerevisiae
Length: 586 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOL1.

Description E-value Query
Range
Subject
Range
gi|151944583 - gi|151944583|gb|EDN62861.1| conserved protein [Saccharomyces cerevisiae YJM789]
HOL1 - Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance tran...
HOL1_YEAST - Protein HOL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOL1 PE=1 SV=1
2.0E-94 [1..586] [1..586]
gi|25308886, gi|... - gi|3859693|emb|CAA21968.1| transport protein [Candida albicans], pir||T52148 transport protein hol1 ...
1.0E-79 [3..586] [16..586]
SPBC1271.10c - membrane transporter
YHMA_SCHPO - Uncharacterized MFS-type transporter C1271.10c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...
6.0E-79 [11..584] [8..561]
gi|21225257, gi|... - gi|7649556|emb|CAB89031.1| putative membrane transport protein. [Streptomyces coelicolor A3(2)], gi|...
1.0E-72 [29..537] [4..440]
gi|223644446, gi... - gi|241956766|ref|XP_002421103.1| multidrug transporter; plasma membrane transporter of the major fac...
gi|2951670 - gi|2951670|emb|CAA12730.1| multidrug transporter [Candida dubliniensis]
4.0E-72 [2..575] [50..556]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-70 [2..576] [36..552]
CYHR_CANMA - Cycloheximide resistance protein OS=Candida maltosa GN=CYHR PE=3 SV=1
4.0E-70 [2..576] [36..552]
gi|19386936 - gi|19386936|gb|AAL87047.1|AF448056_3 putative dothistromin transporter [Mycosphaerella pini]
gi|19386936 - gi|19386936|gb|AAL87047.1|AF448056_3 putative dothistromin transporter [Mycosphaerella pini]
1.0E-68 [9..546] [2..499]

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Predicted Domain #1
Region A:
Residues: [1-63]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKYTNRDHP DYIPGTFNIY SSQNLENGII YESKLKKTSS GVVLIPQPSY SPNDPLNWSS  60
   61 WRK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.583 0.154 transport d.9.1 Interleukin 8-like chemokines
View Download 0.644 0.103 plasma membrane g.18.1 Complement control module/SCR domain
View Download 0.449 0.000 mitochondrion d.68.7 R3H domain
View Download 0.554 N/A N/A d.9.2 Description not found.
View Download 0.522 N/A N/A d.9.2 Description not found.
View Download 0.442 N/A N/A d.9.1 Interleukin 8-like chemokines
View Download 0.422 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.392 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.340 N/A N/A d.68.3 SirA-like
View Download 0.292 N/A N/A d.74.2 C-terminal domain of arginine repressor
View Download 0.234 N/A N/A c.47.1 Thioredoxin-like

Predicted Domain #2
Region A:
Residues: [64-505]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LAHFGLMAFI TAFTAATSND AGAAQDSLNE IYGISYDSMN TGAGVLFLGI GWSTLFLAPF  60
   61 ANLYGRKITY IVCTTLGLFG ALWFALAKRT SDTIWSQLFV GISESCAEAQ VQLSLSDIFF 120
  121 QHQLGSVLTV YIMCTSIGTF LGPLIAGYIS AFTNFRWVGW VAVIISGGLL ITIIFGCEET 180
  181 YFDRGQYMTP LTSCQSGYED GTTLQNSDNT AVSRRKRHLD AKLSTPGAMG EKGVDLSETA 240
  241 EFEVNNEEEV TIPETRELID GSKEHLKPYP KRVAILTKAT NLKGYGFKQY FKYLKINLRM 300
  301 FLFPPVWLSG MFWGIQDVFL TFYLTTQESA YYEPPWNYSD FGVAIMNVPT LIGAVIGCIC 360
  361 AGIVSDYFVL WMARHNRGIL EAEFRLYFSI ATAIIGPAGL LMFGIGTARQ WPWQAIYVGL 420
  421 GFVGFAWGCS GDIAMAYLMD CY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.39794
Match: 1lviA_
Description: No description for 1lviA_ was found.

Predicted Domain #3
Region A:
Residues: [506-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDMVLEGMVC TAIINNTISC IFTFTCSDWL AASGTENTYI ALAVINFGIT AFALPMYYYG  60
   61 KRIRLWTKRW YLQSVNLRDG V

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.607 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.480 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.453 a.64.1 Saposin
View Download 0.453 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.443 a.46.1 Methionine synthase domain
View Download 0.441 a.112.1 Description not found.
View Download 0.427 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.383 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.367 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.363 b.59.1 XRCC4, N-terminal domain
View Download 0.359 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.323 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.321 a.22.1 Histone-fold
View Download 0.320 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.315 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.312 b.1.2 Fibronectin type III
View Download 0.311 d.15.7 Immunoglobulin-binding domains
View Download 0.303 a.4.1 Homeodomain-like
View Download 0.301 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.300 b.1.1 Immunoglobulin
View Download 0.288 a.46.1 Methionine synthase domain
View Download 0.285 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.274 a.22.1 Histone-fold
View Download 0.272 d.13.1 HIT-like
View Download 0.272 a.22.1 Histone-fold
View Download 0.269 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.265 a.64.2 Bacteriocin AS-48
View Download 0.262 a.16.1 S15/NS1 RNA-binding domain
View Download 0.259 d.68.4 YhbY-like
View Download 0.257 a.4.5 "Winged helix" DNA-binding domain
View Download 0.251 a.74.1 Cyclin-like
View Download 0.249 d.101.1 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domains 2 and 5
View Download 0.227 a.3.1 Cytochrome c
View Download 0.225 a.126.1 Serum albumin-like
View Download 0.224 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.222 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.215 d.6.1 Prion-like
View Download 0.213 a.77.1 DEATH domain
View Download 0.213 a.60.11 Hypothetical protein YjbJ
View Download 0.207 d.6.1 Prion-like
View Download 0.201 d.110.4 SNARE-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle