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View Structure Prediction Details

Protein: MSB3
Organism: Saccharomyces cerevisiae
Length: 633 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MSB3.

Description E-value Query
Range
Subject
Range
gi|190409261 - gi|190409261|gb|EDV12526.1| GTPase activating protein for Ypt6 [Saccharomyces cerevisiae RM11-1a]
MSB3 - GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its acti...
gi|151944254 - gi|151944254|gb|EDN62533.1| GTPase-activating protein [Saccharomyces cerevisiae YJM789]
gi|207341956 - gi|207341956|gb|EDZ69870.1| YNL293Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GYP3_YEAST - GTPase-activating protein GYP3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSB3 PE=1...
0.0 [1..633] [1..633]
TBCD1_BOVIN, TBC... - TBC1 domain family member 1 (Fragment) OS=Bos taurus GN=TBC1D1 PE=2 SV=1, (O97790) TBC1 domain famil...
6.0E-91 [36..628] [5..537]
gi|14041976 - gi|14041976|dbj|BAB55057.1| unnamed protein product [Homo sapiens]
1.0E-90 [24..628] [113..655]
gi|9790251, gi|9... - gi|988221|gb|AAA85223.1| Tbc1, gi|9790251|ref|NP_062610.1| TBC1 domain family, member 1 [Mus musculu...
1.0E-83 [24..615] [565..1094]

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Predicted Domain #1
Region A:
Residues: [1-131]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNDQQRFSL QNRTVLAHPY KRLGGAFTVK SPSVPNFHDK MHSDHSSSDS ALVNGSFRAN  60
   61 DHRSVEPSCL GQASPSEHDG NLSVIDLYGD EVESQRAEGE DDDDNNGDNG NEDLEEVHSD 120
  121 DLDLVPDDDN R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.338 a.1.1 Globin-like
View Download 0.338 a.1.1 Globin-like
View Download 0.213 c.26.1 Nucleotidylyl transferase

Predicted Domain #2
Region A:
Residues: [132-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRVELEGAAS ATSANSNGIN NTHFDRYGFK KQNNYISEAE YDKWWVEYSQ YCVRRKHKWQ  60
   61 LLLEKSGLPV TDDSPSRFPS KSERLKRYVR KGIPAEWRGN AWWHFARGQE KLNKNKGVYS 120
  121 QLLRKMKQIK KQNPNEKQVQ DLDIIERDLN RTFPDNIHFQ SSLHNKEGPP IIKSLRRVLV 180
  181 AFSLYNPKIG YCQSMNFLAG LLLLFLDEER AFWMLVIITS RYLPGVHNIN LE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [447-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RIWDCLFYEE SH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.154902
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [364-446]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVNIDQGVLM LCVKEYIPEV WSYIKPSIDH HQKNNKTFSP SNKKVLFNMQ KNEFLYRLPP  60
   61 ITLCTASWFM SCFVGVVPIE TTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.154902
Match: 1fkmA_
Description: Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [459-525]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLFKVSLAVL KLSEHDLSKI KPRNNSLNYS WGSNLNQRGG SMGQEDSDME IFQVIQTFPK  60
   61 TLLNPNE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.551 a.4.5 "Winged helix" DNA-binding domain
View Download 0.548 a.4.1 Homeodomain-like
View Download 0.526 a.60.2 RuvA domain 2-like
View Download 0.496 a.4.11 RNA polymerase subunit RPB10
View Download 0.521 a.46.1 Methionine synthase domain
View Download 0.481 a.4.5 "Winged helix" DNA-binding domain
View Download 0.475 a.4.1 Homeodomain-like
View Download 0.467 a.4.11 RNA polymerase subunit RPB10
View Download 0.453 a.4.5 "Winged helix" DNA-binding domain
View Download 0.420 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.413 a.4.5 "Winged helix" DNA-binding domain
View Download 0.407 a.60.2 RuvA domain 2-like
View Download 0.405 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.402 a.2.7 tRNA-binding arm
View Download 0.363 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.356 a.4.5 "Winged helix" DNA-binding domain
View Download 0.354 a.60.1 SAM/Pointed domain
View Download 0.340 a.64.2 Bacteriocin AS-48
View Download 0.331 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.324 a.60.12 DNA polymerase beta-like, second domain
View Download 0.317 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.313 a.60.2 RuvA domain 2-like
View Download 0.312 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.307 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.301 d.58.3 Protease propeptides/inhibitors
View Download 0.294 a.4.5 "Winged helix" DNA-binding domain
View Download 0.294 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.291 a.65.1 Annexin
View Download 0.290 a.4.1 Homeodomain-like
View Download 0.287 a.60.1 SAM/Pointed domain
View Download 0.286 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.284 a.60.2 RuvA domain 2-like
View Download 0.282 a.112.1 Description not found.
View Download 0.278 a.4.8 Ribosomal protein S18
View Download 0.274 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.273 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.269 a.4.1 Homeodomain-like
View Download 0.267 a.60.8 HRDC-like
View Download 0.261 a.36.1 Signal peptide-binding domain
View Download 0.255 a.2.3 Chaperone J-domain
View Download 0.254 a.4.5 "Winged helix" DNA-binding domain
View Download 0.253 a.55.1 IHF-like DNA-binding proteins
View Download 0.249 a.60.2 RuvA domain 2-like
View Download 0.242 a.112.1 Description not found.
View Download 0.239 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.236 a.105.1 FIS-like
View Download 0.235 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.228 a.4.1 Homeodomain-like
View Download 0.221 d.120.1 Cytochrome b5
View Download 0.220 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.214 a.3.1 Cytochrome c
View Download 0.211 a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #5
Region A:
Residues: [526-633]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IFEKIIFKRR FNLNRLDQDE IDRCRKFVAA QRLKFKTYGE LLGNSTSEAD LPINDNTDNK  60
   61 GIHITSDAVN EALSSEVYGF KKSLAGVHWN NSIKEKVKQM RKKKDKGD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.223 0.081 Rab GTPase activator activity a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.273 0.078 Rab GTPase activator activity d.80.1 Tautomerase/MIF
View Download 0.230 0.060 Rab GTPase activator activity a.74.1 Cyclin-like
View Download 0.294 0.053 Rab GTPase activator activity a.7.1 Spectrin repeat
View Download 0.334 0.043 Rab GTPase activator activity a.7.8 GAT domain
View Download 0.218 N/A N/A a.74.1 Cyclin-like
View Download 0.210 N/A N/A a.74.1 Cyclin-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle