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View Structure Prediction Details

Protein: PUS4
Organism: Saccharomyces cerevisiae
Length: 403 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUS4.

Description E-value Query
Range		 Subject
Range
PUS4 - Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved...
gi|207341957 - gi|207341957|gb|EDZ69871.1| YNL292Wp-like protein [Saccharomyces cerevisiae AWRI1631]
PUS4_YEAST - tRNA pseudouridine synthase 4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PUS4 PE=1 ...
gi|190409260 - gi|190409260|gb|EDV12525.1| pseudouridine synthase [Saccharomyces cerevisiae RM11-1a]
gi|151944255 - gi|151944255|gb|EDN62534.1| pseudouridine synthase [Saccharomyces cerevisiae YJM789]
 0.0 [1..403] [1..403]
CBF5_EMENI - Centromere/microtubule-binding protein CBF5 OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CB...
CBF5_EMENI - Centromere/microtubule-binding protein CBF5 OS=Emericella nidulans GN=cbf5 PE=2 SV=1
 8.0E-95 [8..375] [31..348]
CBF5_ASPFU - Centromere/microtubule-binding protein cbf5 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / ...
CBF5_ASPFU - Centromere/microtubule-binding protein cbf5 OS=Aspergillus fumigatus GN=cbf5 PE=2 SV=1
gi|159126206 - gi|159126206|gb|EDP51322.1| pseudouridylate synthase family protein [Aspergillus fumigatus A1163]
 1.0E-94 [8..375] [36..353]
gi|7378766 - gi|7378766|emb|CAB85492.1| putative kinetochore protein [Hordeum vulgare subsp. vulgare]
 2.0E-93 [8..375] [73..389]
gi|8572671 - gi|8572671|gb|AAF77119.1|AF234319_1 Cbf5p [Euglena gracilis]
 4.0E-92 [8..375] [36..352]
gi|108708379, gi... - gi|34896278|ref|NP_909483.1| putative centromere/microtubule binding protein [Oryza sativa], gi|2156...
 9.0E-92 [8..375] [78..394]
CBF5_CANAL - Centromere/microtubule-binding protein CBF5 OS=Candida albicans GN=CBF5 PE=3 SV=1
gi|238878534 - gi|238878534|gb|EEQ42172.1| centromere/microtubule-binding protein CBF5 [Candida albicans WO-1]
CBF5_CANAL - Centromere/microtubule-binding protein CBF5 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=C...
 1.0E-91 [8..375] [31..347]
DKC1_MOUSE - H/ACA ribonucleoprotein complex subunit 4 OS=Mus musculus GN=Dkc1 PE=1 SV=3
 2.0E-91 [8..375] [60..376]
CBF5_KLULA - Centromere/microtubule-binding protein CBF5 OS=Kluyveromyces lactis GN=CBF5 PE=3 SV=1
CBF5_KLULA - Centromere/microtubule-binding protein CBF5 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / D...
 3.0E-91 [8..375] [29..345]

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Predicted Domain #1
Region A:
Residues: [1-282] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNGIFAIEKP SGITSNQFML KLQHALTKSQ VFSKEIQRAT AERKQQYEKQ TGKKASKRKL  60
   61 RKVSKVKMGH GGTLDPLASG VLVIGIGAGT KKLANYLSGT VKVYESEALF GVSTTSGDVE 120
  121 GEILSQNSVK HLNFDDLKTV EEKFVGQLKQ TPPIYAALKM DGKPLHEYAR EGKPLPRAIE 180
  181 PRQVTIYDLK VFSDSLKRDH DYPLLRPTTE EAVDTVKNLN ANMLNDVLYF SKEYTEKHGL 240
  241 DSEVAKVEEP FPLSEQEEQE IQKEGDSYRA PKLHFKANVS SG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 267.30103
Match: 1k8wA_
Description: Pseudouridine synthase II TruB, C-terminal domain; Pseudouridine synthase II TruB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
pseudouridine synthase activity 5.19957135839682 bayes_pls_golite062009
intramolecular transferase activity 3.78688422405974 bayes_pls_golite062009
isomerase activity 2.91720316078381 bayes_pls_golite062009
catalytic activity 2.02180970970004 bayes_pls_golite062009
transcription regulator activity 1.21173188039059 bayes_pls_golite062009
ligase activity 1.08945974848348 bayes_pls_golite062009
DNA binding 0.950713703876672 bayes_pls_golite062009
nucleic acid binding 0.909704702595901 bayes_pls_golite062009
binding 0.730744558777463 bayes_pls_golite062009
RNA binding 0.706879359688019 bayes_pls_golite062009
transcription factor activity 0.459074630080185 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [283-403] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TYIRSLVSDI GKSMRSSCYM VKLIRLQQQD WSLEKNNVFQ LTDFTERDEK VWSKVLEKVL  60
   61 DEGATVDVIE ELKKAEKEIP ADVKECIVSS DQPGDEATAE TIETANAEEH SNTLKRKIEQ 120
  121 V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 267.30103
Match: 1k8wA_
Description: Pseudouridine synthase II TruB, C-terminal domain; Pseudouridine synthase II TruB
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle