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View Structure Prediction Details

Protein: MID1
Organism: Saccharomyces cerevisiae
Length: 548 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MID1.

Description E-value Query
Range
Subject
Range
gi|151944256 - gi|151944256|gb|EDN62535.1| conserved protein [Saccharomyces cerevisiae YJM789]
MID1_YEAST - Stretch-activated cation channel MID1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MI...
gi|207341958 - gi|207341958|gb|EDZ69872.1| YNL291Cp-like protein [Saccharomyces cerevisiae AWRI1631]
MID1 - N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stre...
gi|190409259 - gi|190409259|gb|EDV12524.1| N-glycosylated integral plasma membrane protein [Saccharomyces cerevisia...
0.0 [1..548] [1..548]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [123..507] [93..430]
EHS1_SCHPO - Calcium influx-promoting protein ehs1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ehs1...
yam8 - calcium transport protein
0.0 [123..507] [93..430]

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Predicted Domain #1
Region A:
Residues: [1-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIVWQALFVV YCLFTTSIHG LFQDFNPFAN KNISLKFPSL NRWEKNVMAT GQQTIINSDS  60
   61 IYEWTPILSN ITAGKKDSFV FTIDAEASGY GFAPTYEVLM FISGNICQMP MNRSDVDLTI 120
  121 YYSFNETVLE NPNIGQSAVF QDGYIQALAI SPVQSSSSNA TSTYSNLYVV AELVNSTTEQ 180
  181 PLSSSDASEN WEYRLSISEN DLVFQWDVRP WVEVLDTDMN SALLSTGNVT ADAKVYHNYS 240
  241 IYDPS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [246-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LYDLYVYSYE DSVQLNQNYN LSLCAVKNGP YLVSSQNTSN ATVTSNSTNP LERTDLAIQK  60
   61 KITEYGGSVT EMFYVTGLNA STTYVAYLTK KISNGDGLSS VGGILFSHVY FTTRSTDVCS 120
  121 LIFGLDFCSD VAYSVPTSSF SVGNKTLMAQ TYDHIAEALY ANFSKALQLI SCDADKDARY 180
  181 SPVMTCDDCA EAYRDWVCAV SIPRCTTTSS QYYIHRDKSH NRNDYLNKFI KPLDDYYEIL 240
  241 PCIDMCYTLV RNCPSDFQFS CPNDLTTEDL LYQSYNFYMD TDYSTCNYIG NSSLMVIHPL 300
  301 DDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [218-341]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMNSALLSTG NVTADAKVYH NYSIYDPSLY DLYVYSYEDS VQLNQNYNLS LCAVKNGPYL  60
   61 VSSQNTSNAT VTSNSTNPLE RTDLAIQKKI TEYGGSVTEM FYVTGLNAST TYVAYLTKKI 120
  121 SNGD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [342-548]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLSSVGGILF SHVYFTTRST DVCSLIFGLD FCSDVAYSVP TSSFSVGNKT LMAQTYDHIA  60
   61 EALYANFSKA LQLISCDADK DARYSPVMTC DDCAEAYRDW VCAVSIPRCT TTSSQYYIHR 120
  121 DKSHNRNDYL NKFIKPLDDY YEILPCIDMC YTLVRNCPSD FQFSCPNDLT TEDLLYQSYN 180
  181 FYMDTDYSTC NYIGNSSLMV IHPLDDT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.62
Match: 1ijxA
Description: Secreted Frizzled-related protein 3 (SFRP-3;fzb)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transmembrane receptor activity 1.81467703148571 bayes_pls_golite062009
receptor activity 1.79586924429875 bayes_pls_golite062009
binding 1.58747760460167 bayes_pls_golite062009
protein binding 1.24658797699128 bayes_pls_golite062009
signal transducer activity 1.02200332848929 bayes_pls_golite062009
molecular transducer activity 1.02200332848929 bayes_pls_golite062009
Wnt receptor activity 0.268954856682316 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle